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Cognitive functioning related to quality of life in schizophrenia.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 01; 32(1):280-7.PN

Abstract

The present study compared the cognitive function of patients with schizophrenia to that of healthy subjects, and investigated the relationships between cognitive function and quality of life (QOL). Participants consisted of 53 patients meeting DSM-IV criteria for schizophrenia and 31 normal controls. All participants completed a neuropsychological test battery assessing executive function, verbal memory, and social knowledge. QOL was rated using the Schizophrenia Quality of Life Scale. Patients with schizophrenia showed lower performance across various cognitive measures of memory, including the Sentence Memory Test, the Verbal Learning Test, and the Script Test, as well as the Rule Shift Cards Test of executive function. Multiple regression analyses were used to evaluate the neuropsychological measures and clinical symptoms to predict QOL. The QOL total score, the social initiative score or the empathy score were significantly predicted by the Script or/and the Sentence Memory. Neuropsychological functioning was unrelated to most QOL scores in the presence of clinical symptoms, while ability of empathy in the QOL was predicted by performance of the Sentence Memory Test. These results demonstrated patients with schizophrenia have deficits in executive function, memory and learning, and social knowledge, and that social knowledge and memory are related to QOL. Thus, in patients with schizophrenia, deficits in social knowledge appear to be associated with current QOL in general, and specifically with the capacity for empathy and social initiative.

Authors+Show Affiliations

Department of Neuropsychology and Neuropsychiatry, Graduate School of Medicine, University of Toyama, Toyama, Japan. mmatsui@las.u-toyama.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17884266

Citation

Matsui, Mié, et al. "Cognitive Functioning Related to Quality of Life in Schizophrenia." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 32, no. 1, 2008, pp. 280-7.
Matsui M, Sumiyoshi T, Arai H, et al. Cognitive functioning related to quality of life in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(1):280-7.
Matsui, M., Sumiyoshi, T., Arai, H., Higuchi, Y., & Kurachi, M. (2008). Cognitive functioning related to quality of life in schizophrenia. Progress in Neuro-psychopharmacology & Biological Psychiatry, 32(1), 280-7.
Matsui M, et al. Cognitive Functioning Related to Quality of Life in Schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 1;32(1):280-7. PubMed PMID: 17884266.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive functioning related to quality of life in schizophrenia. AU - Matsui,Mié, AU - Sumiyoshi,Tomiki, AU - Arai,Hirofumi, AU - Higuchi,Yuko, AU - Kurachi,Masayoshi, Y1 - 2007/08/24/ PY - 2007/06/03/received PY - 2007/08/10/revised PY - 2007/08/17/accepted PY - 2007/9/22/pubmed PY - 2008/5/3/medline PY - 2007/9/22/entrez SP - 280 EP - 7 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 32 IS - 1 N2 - The present study compared the cognitive function of patients with schizophrenia to that of healthy subjects, and investigated the relationships between cognitive function and quality of life (QOL). Participants consisted of 53 patients meeting DSM-IV criteria for schizophrenia and 31 normal controls. All participants completed a neuropsychological test battery assessing executive function, verbal memory, and social knowledge. QOL was rated using the Schizophrenia Quality of Life Scale. Patients with schizophrenia showed lower performance across various cognitive measures of memory, including the Sentence Memory Test, the Verbal Learning Test, and the Script Test, as well as the Rule Shift Cards Test of executive function. Multiple regression analyses were used to evaluate the neuropsychological measures and clinical symptoms to predict QOL. The QOL total score, the social initiative score or the empathy score were significantly predicted by the Script or/and the Sentence Memory. Neuropsychological functioning was unrelated to most QOL scores in the presence of clinical symptoms, while ability of empathy in the QOL was predicted by performance of the Sentence Memory Test. These results demonstrated patients with schizophrenia have deficits in executive function, memory and learning, and social knowledge, and that social knowledge and memory are related to QOL. Thus, in patients with schizophrenia, deficits in social knowledge appear to be associated with current QOL in general, and specifically with the capacity for empathy and social initiative. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/17884266/Cognitive_functioning_related_to_quality_of_life_in_schizophrenia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(07)00305-3 DB - PRIME DP - Unbound Medicine ER -