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Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 01; 32(1):140-4.PN

Abstract

Ketamine is a non-competitive antagonist to the phencyclidine site of N-methyl-d-aspartate (NMDA) receptor. Clinical findings point to a rapid onset of action for ketamine on the treatment of major depression. Considering that classic antidepressants may take long-lasting time to exhibit their main therapeutic effects, the present study aims to compare the behavioral effects and the BDNF hippocampus levels of acute administration of ketamine and imipramine in rats. To this aim, rats were acutely treated with ketamine (5, 10 and 15 mg/kg) and imipramine (10, 20 and 30 mg/kg) and animal behavioral was assessed in the forced swimming and open-field tests. Afterwards, BDNF protein hippocampal levels were assessed in imipramine- and ketamine-treated rats by ELISA-sandwich assay. We observed that ketamine at the doses of 10 and 15 mg/kg, and imipramine at 20 and 30 mg/kg reduced immobility time compared to saline group, without affecting locomotor activity. Interesting enough, acute administration of ketamine at the higher dose, but not imipramine, increased BDNF protein levels in the rat hippocampus. In conclusion, our findings suggest that the increase of hippocampal BDNF protein levels induced by ketamine might be necessary to produce a rapid onset of antidepressant action.

Authors+Show Affiliations

Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17884272

Citation

Garcia, Lêda S B., et al. "Acute Administration of Ketamine Induces Antidepressant-like Effects in the Forced Swimming Test and Increases BDNF Levels in the Rat Hippocampus." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 32, no. 1, 2008, pp. 140-4.
Garcia LS, Comim CM, Valvassori SS, et al. Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(1):140-4.
Garcia, L. S., Comim, C. M., Valvassori, S. S., Réus, G. Z., Barbosa, L. M., Andreazza, A. C., Stertz, L., Fries, G. R., Gavioli, E. C., Kapczinski, F., & Quevedo, J. (2008). Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus. Progress in Neuro-psychopharmacology & Biological Psychiatry, 32(1), 140-4.
Garcia LS, et al. Acute Administration of Ketamine Induces Antidepressant-like Effects in the Forced Swimming Test and Increases BDNF Levels in the Rat Hippocampus. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 1;32(1):140-4. PubMed PMID: 17884272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus. AU - Garcia,Lêda S B, AU - Comim,Clarissa M, AU - Valvassori,Samira S, AU - Réus,Gislaine Z, AU - Barbosa,Luciana M, AU - Andreazza,Ana Cristina, AU - Stertz,Laura, AU - Fries,Gabriel R, AU - Gavioli,Elaine Cristina, AU - Kapczinski,Flavio, AU - Quevedo,João, Y1 - 2007/08/08/ PY - 2007/05/24/received PY - 2007/07/31/revised PY - 2007/07/31/accepted PY - 2007/9/22/pubmed PY - 2008/5/3/medline PY - 2007/9/22/entrez SP - 140 EP - 4 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 32 IS - 1 N2 - Ketamine is a non-competitive antagonist to the phencyclidine site of N-methyl-d-aspartate (NMDA) receptor. Clinical findings point to a rapid onset of action for ketamine on the treatment of major depression. Considering that classic antidepressants may take long-lasting time to exhibit their main therapeutic effects, the present study aims to compare the behavioral effects and the BDNF hippocampus levels of acute administration of ketamine and imipramine in rats. To this aim, rats were acutely treated with ketamine (5, 10 and 15 mg/kg) and imipramine (10, 20 and 30 mg/kg) and animal behavioral was assessed in the forced swimming and open-field tests. Afterwards, BDNF protein hippocampal levels were assessed in imipramine- and ketamine-treated rats by ELISA-sandwich assay. We observed that ketamine at the doses of 10 and 15 mg/kg, and imipramine at 20 and 30 mg/kg reduced immobility time compared to saline group, without affecting locomotor activity. Interesting enough, acute administration of ketamine at the higher dose, but not imipramine, increased BDNF protein levels in the rat hippocampus. In conclusion, our findings suggest that the increase of hippocampal BDNF protein levels induced by ketamine might be necessary to produce a rapid onset of antidepressant action. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/17884272/Acute_administration_of_ketamine_induces_antidepressant_like_effects_in_the_forced_swimming_test_and_increases_BDNF_levels_in_the_rat_hippocampus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(07)00269-2 DB - PRIME DP - Unbound Medicine ER -