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Novel clinical and serological aspects in non-allergic asthma.
Respir Med. 2007 Dec; 101(12):2526-33.RM

Abstract

BACKGROUND

We have recently observed that skin reactivity to autologous serum injection is common in patients with non-allergic asthma. However, clinical significance of skin reactivity to autologous serum remains to be defined.

OBJECTIVE

To evaluate the possible relation between skin reactivity to autologous serum and clinical and laboratory characteristics in a series of patients with non-allergic asthma.

METHODS

Fifty-five patients with non-allergic asthma underwent in vivo autologous serum skin test (ASST) and in vitro basophil histamine release assay using basophils from a normal donor. Clinical and laboratory characteristics including peripheral blood eosinophilia, antinuclear antibodies and total IgE concentration were evaluated. As control, ASST was performed in 10 allergic asthmatic patients, 10 patients with allergic rhinitis and 10 normal subjects.

RESULTS

ASST was positive in 29/55 non-allergic asthmatics (53%), whereas it was negative in all 30 control subjects (P<0.001). The sera of 6 out of 51 patients induced in vitro histamine release from autologous basophils. The sera from two patients induced histamine release from membrane IgE-stripped basophils. A significant predominance of female sex (83%) and a high incidence of antinuclear antibodies (ANA) positivity (55%) were found among ASST-positive patients.

CONCLUSION

These findings indicate that ASST is positive in about half patients with non-allergic asthma and that a proportion of patients (16%) has functional evidence of circulating histamine-releasing factors. In addition, predominance of female sex and frequent ANA positivity are in line with an autoimmune basis of non-allergic asthma.

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Authors+Show Affiliations

Comi AL
Divisione di Medicina Interna e Pneumologia, Ospedale Fatebenefratelli, Corso di Porta Nuova, Milano, Italy.
Tedeschi A
No affiliation info available
Lorini M
No affiliation info available
Miadonna A
No affiliation info available

MeSH

AdultAgedAntibodies, AntinuclearAsthmaAutoimmune DiseasesBasophilsCase-Control StudiesEosinophiliaFemaleHistamine ReleaseHumansHypersensitivity, ImmediateImmunoglobulin EImmunologic TestsMaleMiddle AgedRhinitis, Allergic, SeasonalSerumSkinSkin TestsTransplantation, Autologous

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17884421

Citation

Comi, A L., et al. "Novel Clinical and Serological Aspects in Non-allergic Asthma." Respiratory Medicine, vol. 101, no. 12, 2007, pp. 2526-33.
Comi AL, Tedeschi A, Lorini M, et al. Novel clinical and serological aspects in non-allergic asthma. Respir Med. 2007;101(12):2526-33.
Comi, A. L., Tedeschi, A., Lorini, M., & Miadonna, A. (2007). Novel clinical and serological aspects in non-allergic asthma. Respiratory Medicine, 101(12), 2526-33.
Comi AL, et al. Novel Clinical and Serological Aspects in Non-allergic Asthma. Respir Med. 2007;101(12):2526-33. PubMed PMID: 17884421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel clinical and serological aspects in non-allergic asthma. AU - Comi,A L, AU - Tedeschi,A, AU - Lorini,M, AU - Miadonna,A, Y1 - 2007/09/19/ PY - 2007/03/04/received PY - 2007/05/31/revised PY - 2007/07/16/accepted PY - 2007/9/22/pubmed PY - 2008/3/1/medline PY - 2007/9/22/entrez SP - 2526 EP - 33 JF - Respiratory medicine JO - Respir Med VL - 101 IS - 12 N2 - BACKGROUND: We have recently observed that skin reactivity to autologous serum injection is common in patients with non-allergic asthma. However, clinical significance of skin reactivity to autologous serum remains to be defined. OBJECTIVE: To evaluate the possible relation between skin reactivity to autologous serum and clinical and laboratory characteristics in a series of patients with non-allergic asthma. METHODS: Fifty-five patients with non-allergic asthma underwent in vivo autologous serum skin test (ASST) and in vitro basophil histamine release assay using basophils from a normal donor. Clinical and laboratory characteristics including peripheral blood eosinophilia, antinuclear antibodies and total IgE concentration were evaluated. As control, ASST was performed in 10 allergic asthmatic patients, 10 patients with allergic rhinitis and 10 normal subjects. RESULTS: ASST was positive in 29/55 non-allergic asthmatics (53%), whereas it was negative in all 30 control subjects (P<0.001). The sera of 6 out of 51 patients induced in vitro histamine release from autologous basophils. The sera from two patients induced histamine release from membrane IgE-stripped basophils. A significant predominance of female sex (83%) and a high incidence of antinuclear antibodies (ANA) positivity (55%) were found among ASST-positive patients. CONCLUSION: These findings indicate that ASST is positive in about half patients with non-allergic asthma and that a proportion of patients (16%) has functional evidence of circulating histamine-releasing factors. In addition, predominance of female sex and frequent ANA positivity are in line with an autoimmune basis of non-allergic asthma. SN - 0954-6111 UR - https://www.unboundmedicine.com/medline/citation/17884421/Novel_clinical_and_serological_aspects_in_non_allergic_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(07)00320-4 DB - PRIME DP - Unbound Medicine ER -