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Phenolic antioxidants from the whole plant of Phyllanthus urinaria.

Abstract

The 1,1-diphenyl-2-picrydydrazyl (DPPH) assay on the extract of Phyllanthus urinaria L. (Euphorbiaceae) displayed considerable radical-scavenging activity (SC50 = 14.3 microg/ml). Further bioassay-guided purification of the extract led to the isolation of a series of 15 phenolic compounds, including the ellagitannins 1-7, the flavonoids 8-10, and the simple hydroxylated (or glycosylated) aromatic acids 11-15. Their structures were identified by spectroscopic analyses and comparison with authentic samples or literature data. The structure of repandinin B (1) was for the first time fully assigned by 1D- and 2D-NMR experiments. The phenolic compounds 1, 3, 4, 6, 9, 11, and 15 have not been isolated before from the title plant. The antioxidant activities and mushroom-tyrosinase-inhibitory activities of all compounds were determined by DPPH-radical-scavenging and mushroom-tyrosinase-inhibitory assays (Table 2).

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  • Authors+Show Affiliations

    ,

    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.

    , , , ,

    Source

    Chemistry & biodiversity 4:9 2007 Sep pg 2246-52

    MeSH

    Antioxidants
    Biphenyl Compounds
    Flavonoids
    Hydrazines
    Hydrolyzable Tannins
    Monophenol Monooxygenase
    Phenols
    Phyllanthus
    Picrates
    Plant Extracts

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17886844

    Citation

    TY - JOUR T1 - Phenolic antioxidants from the whole plant of Phyllanthus urinaria. AU - Xu,Min, AU - Zha,Zhong-Jun, AU - Qin,Xue-Ling, AU - Zhang,Xiang-Lan, AU - Yang,Chong-Ren, AU - Zhang,Ying-Jun, PY - 2007/9/25/pubmed PY - 2007/12/6/medline PY - 2007/9/25/entrez SP - 2246 EP - 52 JF - Chemistry & biodiversity JO - Chem. Biodivers. VL - 4 IS - 9 N2 - The 1,1-diphenyl-2-picrydydrazyl (DPPH) assay on the extract of Phyllanthus urinaria L. (Euphorbiaceae) displayed considerable radical-scavenging activity (SC50 = 14.3 microg/ml). Further bioassay-guided purification of the extract led to the isolation of a series of 15 phenolic compounds, including the ellagitannins 1-7, the flavonoids 8-10, and the simple hydroxylated (or glycosylated) aromatic acids 11-15. Their structures were identified by spectroscopic analyses and comparison with authentic samples or literature data. The structure of repandinin B (1) was for the first time fully assigned by 1D- and 2D-NMR experiments. The phenolic compounds 1, 3, 4, 6, 9, 11, and 15 have not been isolated before from the title plant. The antioxidant activities and mushroom-tyrosinase-inhibitory activities of all compounds were determined by DPPH-radical-scavenging and mushroom-tyrosinase-inhibitory assays (Table 2). SN - 1612-1880 UR - https://www.unboundmedicine.com/medline/citation/17886844/Phenolic_antioxidants_from_the_whole_plant_of_Phyllanthus_urinaria_ L2 - https://doi.org/10.1002/cbdv.200790183 ER -