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Medication overuse headache: clinical features predicting treatment outcome at 1-year follow-up.

Abstract

We present a prospective study of 240 patients with medication overuse headache (MOH) treated with drug withdrawal and prophylactic medications. At 1-year follow-up, 137 (57.1%) patients were without chronic headache and without medication overuse, eight (3.3%) patients did not improve after withdrawal and 95 (39.6%) relapsed developing recurrent overuse. Age at time of MOH diagnosis, regular use of benzodiazepines, frequency and Migraine Disability Assessment (MIDAS) score of chronic headache, age at onset of primary headache, frequency and MIDAS score of primary headache, ergotamine compound overuse and daily drug intake were significantly different between successfully and unsuccessfully treated patients. Multivariate analysis determined the frequency of primary headache disorder, ergotamine overuse and disability of chronic headache estimated by MIDAS as independent predictors of treatment efficacy at 1-year follow-up.

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  • Authors+Show Affiliations

    ,

    Headache Centre, Institute of Neurology, Clinical Centre of Serbia, Belgrade, Serbia. jzidverc@gmail.com

    , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Age Factors
    Aged
    Aged, 80 and over
    Analgesics
    Female
    Humans
    Male
    Middle Aged
    Migraine Disorders
    Substance Withdrawal Syndrome
    Treatment Outcome

    Pub Type(s)

    Clinical Trial
    Journal Article

    Language

    eng

    PubMed ID

    17888081

    Citation

    Zidverc-Trajkovic, J, et al. "Medication Overuse Headache: Clinical Features Predicting Treatment Outcome at 1-year Follow-up." Cephalalgia : an International Journal of Headache, vol. 27, no. 11, 2007, pp. 1219-25.
    Zidverc-Trajkovic J, Pekmezovic T, Jovanovic Z, et al. Medication overuse headache: clinical features predicting treatment outcome at 1-year follow-up. Cephalalgia. 2007;27(11):1219-25.
    Zidverc-Trajkovic, J., Pekmezovic, T., Jovanovic, Z., Pavlovic, A., Mijajlovic, M., Radojicic, A., & Sternic, N. (2007). Medication overuse headache: clinical features predicting treatment outcome at 1-year follow-up. Cephalalgia : an International Journal of Headache, 27(11), pp. 1219-25.
    Zidverc-Trajkovic J, et al. Medication Overuse Headache: Clinical Features Predicting Treatment Outcome at 1-year Follow-up. Cephalalgia. 2007;27(11):1219-25. PubMed PMID: 17888081.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Medication overuse headache: clinical features predicting treatment outcome at 1-year follow-up. AU - Zidverc-Trajkovic,J, AU - Pekmezovic,T, AU - Jovanovic,Z, AU - Pavlovic,A, AU - Mijajlovic,M, AU - Radojicic,A, AU - Sternic,N, Y1 - 2007/09/21/ PY - 2007/9/25/pubmed PY - 2008/1/11/medline PY - 2007/9/25/entrez SP - 1219 EP - 25 JF - Cephalalgia : an international journal of headache JO - Cephalalgia VL - 27 IS - 11 N2 - We present a prospective study of 240 patients with medication overuse headache (MOH) treated with drug withdrawal and prophylactic medications. At 1-year follow-up, 137 (57.1%) patients were without chronic headache and without medication overuse, eight (3.3%) patients did not improve after withdrawal and 95 (39.6%) relapsed developing recurrent overuse. Age at time of MOH diagnosis, regular use of benzodiazepines, frequency and Migraine Disability Assessment (MIDAS) score of chronic headache, age at onset of primary headache, frequency and MIDAS score of primary headache, ergotamine compound overuse and daily drug intake were significantly different between successfully and unsuccessfully treated patients. Multivariate analysis determined the frequency of primary headache disorder, ergotamine overuse and disability of chronic headache estimated by MIDAS as independent predictors of treatment efficacy at 1-year follow-up. SN - 0333-1024 UR - https://www.unboundmedicine.com/medline/citation/17888081/full_citation L2 - http://journals.sagepub.com/doi/full/10.1111/j.1468-2982.2007.01432.x?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -