Tags

Type your tag names separated by a space and hit enter

Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells.
Cancer Lett 2007; 257(2):216-26CL

Abstract

Plant products such as perillyl alcohol have been reported to possess anti-tumor activities against a number of human cancers though the mechanism of action has not yet been elucidated. The effects of perillyl alcohol (POH) and its metabolite perillic acid (PA) on the proliferation of non small cell lung cancer (NSCLC, A549, and H520) cells were investigated. Both POH and PA elicited dose-dependent cytotoxicity, induced cell cycle arrest and apoptosis with increasing expression of bax, p21 and caspase-3 activity in both the cell lines. Combination studies revealed that exposing the cells to an IC50 concentration of POH or PA sensitized the cells to cisplatin and radiation in a dose-dependent manner. These results indicate that POH and PA in combination therapy may have chemotherapeutic value against NSCLC.

Authors+Show Affiliations

Chemistry Department, University of Nevada, Las Vegas, NV 89154-4003, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17888568

Citation

Yeruva, Laxmi, et al. "Perillyl Alcohol and Perillic Acid Induced Cell Cycle Arrest and Apoptosis in Non Small Cell Lung Cancer Cells." Cancer Letters, vol. 257, no. 2, 2007, pp. 216-26.
Yeruva L, Pierre KJ, Elegbede A, et al. Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells. Cancer Lett. 2007;257(2):216-26.
Yeruva, L., Pierre, K. J., Elegbede, A., Wang, R. C., & Carper, S. W. (2007). Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells. Cancer Letters, 257(2), pp. 216-26.
Yeruva L, et al. Perillyl Alcohol and Perillic Acid Induced Cell Cycle Arrest and Apoptosis in Non Small Cell Lung Cancer Cells. Cancer Lett. 2007 Nov 18;257(2):216-26. PubMed PMID: 17888568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells. AU - Yeruva,Laxmi, AU - Pierre,Keon J, AU - Elegbede,Abiodun, AU - Wang,Robert C, AU - Carper,Stephen W, Y1 - 2007/09/20/ PY - 2007/03/26/received PY - 2007/07/21/revised PY - 2007/07/24/accepted PY - 2007/9/25/pubmed PY - 2008/1/4/medline PY - 2007/9/25/entrez SP - 216 EP - 26 JF - Cancer letters JO - Cancer Lett. VL - 257 IS - 2 N2 - Plant products such as perillyl alcohol have been reported to possess anti-tumor activities against a number of human cancers though the mechanism of action has not yet been elucidated. The effects of perillyl alcohol (POH) and its metabolite perillic acid (PA) on the proliferation of non small cell lung cancer (NSCLC, A549, and H520) cells were investigated. Both POH and PA elicited dose-dependent cytotoxicity, induced cell cycle arrest and apoptosis with increasing expression of bax, p21 and caspase-3 activity in both the cell lines. Combination studies revealed that exposing the cells to an IC50 concentration of POH or PA sensitized the cells to cisplatin and radiation in a dose-dependent manner. These results indicate that POH and PA in combination therapy may have chemotherapeutic value against NSCLC. SN - 0304-3835 UR - https://www.unboundmedicine.com/medline/citation/17888568/Perillyl_alcohol_and_perillic_acid_induced_cell_cycle_arrest_and_apoptosis_in_non_small_cell_lung_cancer_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3835(07)00345-X DB - PRIME DP - Unbound Medicine ER -