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Breast-feeding duration and infant atopic manifestations, by maternal allergic status, in the first 2 years of life (KOALA study).
J Pediatr. 2007 Oct; 151(4):347-51, 351.e1-2.JPed

Abstract

OBJECTIVE

To investigate the potential effect of modification by maternal allergic status on the relationship between breast-feeding duration and infant atopic manifestations in the first 2 years of life.

STUDY DESIGN

Data from 2705 infants of the KOALA Birth Cohort Study (The Netherlands) were analyzed. The data were collected by repeated questionnaires at 34 weeks of gestation and 3, 7, 12, and 24 months postpartum. Total and specific immunoglobulin E measurements were performed on venous blood samples collected during home visits at age 2 years. Relationships were analyzed using logistic regression analyses.

RESULTS

Longer duration of breast-feeding was associated with a lower risk for eczema in infants of mothers without allergy or asthma (P(trend) = .01) and slightly lower risk in those of mothers with allergy but no asthma (P(trend) = .14). There was no such association for asthmatic mothers (P(trend) = .87). Longer breast-feeding duration decreased the risk of recurrent wheeze independent of maternal allergy (P(trend) = .02) or asthma status (P(trend) = .06).

CONCLUSIONS

Our findings show that the relationship between breast-feeding and infant eczema in the first 2 years of life is modified by maternal allergic status. The protective effect of breast-feeding on recurrent wheeze may be associated with protection against respiratory infections.

Authors+Show Affiliations

Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands. BEP.Snijders@EPID.unimaas.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17889066

Citation

Snijders, Bianca E P., et al. "Breast-feeding Duration and Infant Atopic Manifestations, By Maternal Allergic Status, in the First 2 Years of Life (KOALA Study)." The Journal of Pediatrics, vol. 151, no. 4, 2007, pp. 347-51, 351.e1-2.
Snijders BE, Thijs C, Dagnelie PC, et al. Breast-feeding duration and infant atopic manifestations, by maternal allergic status, in the first 2 years of life (KOALA study). J Pediatr. 2007;151(4):347-51, 351.e1-2.
Snijders, B. E., Thijs, C., Dagnelie, P. C., Stelma, F. F., Mommers, M., Kummeling, I., Penders, J., van Ree, R., & van den Brandt, P. A. (2007). Breast-feeding duration and infant atopic manifestations, by maternal allergic status, in the first 2 years of life (KOALA study). The Journal of Pediatrics, 151(4), 347-51, e1-2.
Snijders BE, et al. Breast-feeding Duration and Infant Atopic Manifestations, By Maternal Allergic Status, in the First 2 Years of Life (KOALA Study). J Pediatr. 2007;151(4):347-51, 351.e1-2. PubMed PMID: 17889066.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast-feeding duration and infant atopic manifestations, by maternal allergic status, in the first 2 years of life (KOALA study). AU - Snijders,Bianca E P, AU - Thijs,Carel, AU - Dagnelie,Pieter C, AU - Stelma,Foekje F, AU - Mommers,Monique, AU - Kummeling,Ischa, AU - Penders,John, AU - van Ree,Ronald, AU - van den Brandt,Piet A, Y1 - 2007/07/12/ PY - 2006/08/02/received PY - 2006/12/19/revised PY - 2007/03/15/accepted PY - 2007/9/25/pubmed PY - 2007/10/10/medline PY - 2007/9/25/entrez SP - 347-51, 351.e1-2 JF - The Journal of pediatrics JO - J Pediatr VL - 151 IS - 4 N2 - OBJECTIVE: To investigate the potential effect of modification by maternal allergic status on the relationship between breast-feeding duration and infant atopic manifestations in the first 2 years of life. STUDY DESIGN: Data from 2705 infants of the KOALA Birth Cohort Study (The Netherlands) were analyzed. The data were collected by repeated questionnaires at 34 weeks of gestation and 3, 7, 12, and 24 months postpartum. Total and specific immunoglobulin E measurements were performed on venous blood samples collected during home visits at age 2 years. Relationships were analyzed using logistic regression analyses. RESULTS: Longer duration of breast-feeding was associated with a lower risk for eczema in infants of mothers without allergy or asthma (P(trend) = .01) and slightly lower risk in those of mothers with allergy but no asthma (P(trend) = .14). There was no such association for asthmatic mothers (P(trend) = .87). Longer breast-feeding duration decreased the risk of recurrent wheeze independent of maternal allergy (P(trend) = .02) or asthma status (P(trend) = .06). CONCLUSIONS: Our findings show that the relationship between breast-feeding and infant eczema in the first 2 years of life is modified by maternal allergic status. The protective effect of breast-feeding on recurrent wheeze may be associated with protection against respiratory infections. SN - 1097-6833 UR - https://www.unboundmedicine.com/medline/citation/17889066/Breast_feeding_duration_and_infant_atopic_manifestations_by_maternal_allergic_status_in_the_first_2_years_of_life__KOALA_study__ DB - PRIME DP - Unbound Medicine ER -