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Evaluation of the equations to estimate the glomerular filtration rate in kidney transplant recipients.
Transplant Proc. 2007 Sep; 39(7):2210-3.TP

Abstract

This study assessed the performance of three methods for estimating glomerular filtration rate (GFR) in kidney transplant patients: the Cockcroft-Gault formula, the modification of diet in renal disease (MDRD) method, and the four-variable modification of diet in renal disease (four-variable MDRD), both as an overall estimate and as related to clinical disease stage. We analyzed data from 136 renal transplant patients including 84 men in an overall age range of 28 to 76 years. Patients were categorized into three groups according to GFR as determined by the arithmetical mean of the last four creatinine clearance determinations after outlying values had been excluded: group 1, estimated GFR of <30 mL/min (n = 26); group 2, estimated GFR of 30 to 60 mL/min (n = 63);, and group 3, estimated GFR >60 mL/min (n = 33). Fourteen patients were excluded from the analysis because of a high variability between their creatinine clearance determinations. Estimated GFRs using the Cockroft-Gault, MDRD, and four-variable MDRD formulae were compared with GFRs as measured by creatinine clearance. Statistically significant correlations were observed for all three formulae for the overall series and for individual clinical groups. Hence, we concluded that all equations had a similar capacity to predict the GFR. In addition, because of the clear, significant correlation between the MDRD and the four-variable MDRD (r = .992; P = .0001), we believe that the four-variable MDRD can substitute for the MDRD for clinical purposes.

Authors+Show Affiliations

Department of Biochemistry, Hospital Universitari Germans Trias i Pujol, Universidad Autónoma de Barcelona, Badalona, Spain. aezaez@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17889140

Citation

Estrada-Zambrano, A, et al. "Evaluation of the Equations to Estimate the Glomerular Filtration Rate in Kidney Transplant Recipients." Transplantation Proceedings, vol. 39, no. 7, 2007, pp. 2210-3.
Estrada-Zambrano A, Biosca-Adzet C, Bayés-Genís B, et al. Evaluation of the equations to estimate the glomerular filtration rate in kidney transplant recipients. Transplant Proc. 2007;39(7):2210-3.
Estrada-Zambrano, A., Biosca-Adzet, C., Bayés-Genís, B., Doladé-Botias, M., Lauzurica-Valdemoros, R., & Romero-González, R. (2007). Evaluation of the equations to estimate the glomerular filtration rate in kidney transplant recipients. Transplantation Proceedings, 39(7), 2210-3.
Estrada-Zambrano A, et al. Evaluation of the Equations to Estimate the Glomerular Filtration Rate in Kidney Transplant Recipients. Transplant Proc. 2007;39(7):2210-3. PubMed PMID: 17889140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the equations to estimate the glomerular filtration rate in kidney transplant recipients. AU - Estrada-Zambrano,A, AU - Biosca-Adzet,C, AU - Bayés-Genís,B, AU - Doladé-Botias,M, AU - Lauzurica-Valdemoros,R, AU - Romero-González,R, PY - 2007/9/25/pubmed PY - 2007/11/14/medline PY - 2007/9/25/entrez SP - 2210 EP - 3 JF - Transplantation proceedings JO - Transplant Proc VL - 39 IS - 7 N2 - This study assessed the performance of three methods for estimating glomerular filtration rate (GFR) in kidney transplant patients: the Cockcroft-Gault formula, the modification of diet in renal disease (MDRD) method, and the four-variable modification of diet in renal disease (four-variable MDRD), both as an overall estimate and as related to clinical disease stage. We analyzed data from 136 renal transplant patients including 84 men in an overall age range of 28 to 76 years. Patients were categorized into three groups according to GFR as determined by the arithmetical mean of the last four creatinine clearance determinations after outlying values had been excluded: group 1, estimated GFR of <30 mL/min (n = 26); group 2, estimated GFR of 30 to 60 mL/min (n = 63);, and group 3, estimated GFR >60 mL/min (n = 33). Fourteen patients were excluded from the analysis because of a high variability between their creatinine clearance determinations. Estimated GFRs using the Cockroft-Gault, MDRD, and four-variable MDRD formulae were compared with GFRs as measured by creatinine clearance. Statistically significant correlations were observed for all three formulae for the overall series and for individual clinical groups. Hence, we concluded that all equations had a similar capacity to predict the GFR. In addition, because of the clear, significant correlation between the MDRD and the four-variable MDRD (r = .992; P = .0001), we believe that the four-variable MDRD can substitute for the MDRD for clinical purposes. SN - 0041-1345 UR - https://www.unboundmedicine.com/medline/citation/17889140/Evaluation_of_the_equations_to_estimate_the_glomerular_filtration_rate_in_kidney_transplant_recipients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-1345(07)00745-2 DB - PRIME DP - Unbound Medicine ER -