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Inhibition errors in borderline personality disorder with psychotic-like symptoms.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 01; 32(1):267-73.PN

Abstract

BACKGROUND

The aim of this study was to examine whether patients with borderline personality disorder (BPD) have deficits in cognitive inhibition as measured with an anti-saccade eye task similar to patients with schizophrenia (Sz). Furthermore, we investigated whether these inhibition errors were more prominent among BPD patients with psychotic-like symptoms than among BPD patients without these symptoms.

METHODS

An anti-saccade task was administered in 32 BPD patients (among them, 20 had with psychotic-like symptoms), 21 patients with recent onset schizophrenia (Sz), and 25 healthy controls (HC). The percentage inhibition errors in the anti-saccade task were the primary outcome variable, in addition, the percentage of anticipatory errors was measured.

RESULTS

Sz patients showed more inhibition errors than HC and BPD (p<.001 and p<.05 resp.), whereas BPD patients scored in between Sz and HC. The difference with HC was significant as well (p<.05). BPD patients with psychotic-like symptoms showed more inhibition errors than BPD patients without these symptoms (p<.05). BPD patients showed more anticipatory errors than HC (p<.001), whereas Sz patients did not (p<.26).

CONCLUSION

The data demonstrate that inhibition deficits, as measured with anti-saccadic eye movement task, may be characteristic among BPD patients and in a larger extent in patients with psychotic-like symptoms. This inhibition deficit was distinct from a general predisposition to response impulsively as measured by anticipatory errors, which was found in the whole group of BPD patients. Psychotic-like symptoms may be an important target dimension for future BPD research and treatment.

Authors+Show Affiliations

Radboud University Nijmegen Medical Center, Dept. of Psychiatry, The Netherlands. k.grootens@psy.umcn.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17889419

Citation

Grootens, Koen P., et al. "Inhibition Errors in Borderline Personality Disorder With Psychotic-like Symptoms." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 32, no. 1, 2008, pp. 267-73.
Grootens KP, van Luijtelaar G, Buitelaar JK, et al. Inhibition errors in borderline personality disorder with psychotic-like symptoms. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(1):267-73.
Grootens, K. P., van Luijtelaar, G., Buitelaar, J. K., van der Laan, A., Hummelen, J. W., & Verkes, R. J. (2008). Inhibition errors in borderline personality disorder with psychotic-like symptoms. Progress in Neuro-psychopharmacology & Biological Psychiatry, 32(1), 267-73.
Grootens KP, et al. Inhibition Errors in Borderline Personality Disorder With Psychotic-like Symptoms. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 1;32(1):267-73. PubMed PMID: 17889419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition errors in borderline personality disorder with psychotic-like symptoms. AU - Grootens,Koen P, AU - van Luijtelaar,Gilles, AU - Buitelaar,Jan K, AU - van der Laan,Annemieke, AU - Hummelen,Jacobus W, AU - Verkes,Robbert J, Y1 - 2007/08/24/ PY - 2006/11/07/received PY - 2007/08/16/revised PY - 2007/08/16/accepted PY - 2007/9/25/pubmed PY - 2008/5/3/medline PY - 2007/9/25/entrez SP - 267 EP - 73 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 32 IS - 1 N2 - BACKGROUND: The aim of this study was to examine whether patients with borderline personality disorder (BPD) have deficits in cognitive inhibition as measured with an anti-saccade eye task similar to patients with schizophrenia (Sz). Furthermore, we investigated whether these inhibition errors were more prominent among BPD patients with psychotic-like symptoms than among BPD patients without these symptoms. METHODS: An anti-saccade task was administered in 32 BPD patients (among them, 20 had with psychotic-like symptoms), 21 patients with recent onset schizophrenia (Sz), and 25 healthy controls (HC). The percentage inhibition errors in the anti-saccade task were the primary outcome variable, in addition, the percentage of anticipatory errors was measured. RESULTS: Sz patients showed more inhibition errors than HC and BPD (p<.001 and p<.05 resp.), whereas BPD patients scored in between Sz and HC. The difference with HC was significant as well (p<.05). BPD patients with psychotic-like symptoms showed more inhibition errors than BPD patients without these symptoms (p<.05). BPD patients showed more anticipatory errors than HC (p<.001), whereas Sz patients did not (p<.26). CONCLUSION: The data demonstrate that inhibition deficits, as measured with anti-saccadic eye movement task, may be characteristic among BPD patients and in a larger extent in patients with psychotic-like symptoms. This inhibition deficit was distinct from a general predisposition to response impulsively as measured by anticipatory errors, which was found in the whole group of BPD patients. Psychotic-like symptoms may be an important target dimension for future BPD research and treatment. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/17889419/Inhibition_errors_in_borderline_personality_disorder_with_psychotic_like_symptoms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(07)00303-X DB - PRIME DP - Unbound Medicine ER -