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Antimicrobial effect of triclosan and triclosan with Gantrez on five common endodontic pathogens.
J Endod. 2007 Oct; 33(10):1239-42.JE

Abstract

Microbial control of the root canal system is one of the key objectives of root canal therapy. Triclosan is a widely accepted broad spectrum antimicrobial agent proven to be effective against many gram-positive and gram-negative bacteria. Triclosan acts by blocking bacterial fatty acid biosynthesis. The addition of Gantrez copolymer has been shown to enhance the antimicrobial activity of triclosan. The purpose of this study was to determine the minimum inhibitory and bactericidal concentrations of triclosan and triclosan with Gantrez against Prevotella intermedia, Fusobacterium nucleatum, Actinomyces naeslundii, Porphyromonas gingivalis, and Enterococcus faecalis. The minimum inhibitory concentration (MIC) of both test solutions was determined for each of the 5 microorganisms by using microtiter serial dilutions. Samples were streaked on 5% sheep blood agar plates and placed in an anaerobic incubator to determine the minimum bactericidal concentration (MBC). The MBC of triclosan ranged from 12-94 microg/mL. The MBC of triclosan with Gantrez ranged from <0.3-10.4 microg/mL. The addition of Gantrez enhanced the bactericidal activity of triclosan. Both triclosan and triclosan with Gantrez demonstrated bactericidal activity against the 5 specific endodontic pathogens.

Authors+Show Affiliations

Private practice, Bloomingdale, Illinois, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17889698

Citation

Nudera, William J., et al. "Antimicrobial Effect of Triclosan and Triclosan With Gantrez On Five Common Endodontic Pathogens." Journal of Endodontics, vol. 33, no. 10, 2007, pp. 1239-42.
Nudera WJ, Fayad MI, Johnson BR, et al. Antimicrobial effect of triclosan and triclosan with Gantrez on five common endodontic pathogens. J Endod. 2007;33(10):1239-42.
Nudera, W. J., Fayad, M. I., Johnson, B. R., Zhu, M., Wenckus, C. S., Begole, E. A., & Wu, C. D. (2007). Antimicrobial effect of triclosan and triclosan with Gantrez on five common endodontic pathogens. Journal of Endodontics, 33(10), 1239-42.
Nudera WJ, et al. Antimicrobial Effect of Triclosan and Triclosan With Gantrez On Five Common Endodontic Pathogens. J Endod. 2007;33(10):1239-42. PubMed PMID: 17889698.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial effect of triclosan and triclosan with Gantrez on five common endodontic pathogens. AU - Nudera,William J, AU - Fayad,Mohamed I, AU - Johnson,Bradford R, AU - Zhu,Min, AU - Wenckus,Christopher S, AU - Begole,Ellen A, AU - Wu,Christine D, Y1 - 2007/07/26/ PY - 2007/04/10/received PY - 2007/06/04/revised PY - 2007/06/11/accepted PY - 2007/9/25/pubmed PY - 2007/12/7/medline PY - 2007/9/25/entrez SP - 1239 EP - 42 JF - Journal of endodontics JO - J Endod VL - 33 IS - 10 N2 - Microbial control of the root canal system is one of the key objectives of root canal therapy. Triclosan is a widely accepted broad spectrum antimicrobial agent proven to be effective against many gram-positive and gram-negative bacteria. Triclosan acts by blocking bacterial fatty acid biosynthesis. The addition of Gantrez copolymer has been shown to enhance the antimicrobial activity of triclosan. The purpose of this study was to determine the minimum inhibitory and bactericidal concentrations of triclosan and triclosan with Gantrez against Prevotella intermedia, Fusobacterium nucleatum, Actinomyces naeslundii, Porphyromonas gingivalis, and Enterococcus faecalis. The minimum inhibitory concentration (MIC) of both test solutions was determined for each of the 5 microorganisms by using microtiter serial dilutions. Samples were streaked on 5% sheep blood agar plates and placed in an anaerobic incubator to determine the minimum bactericidal concentration (MBC). The MBC of triclosan ranged from 12-94 microg/mL. The MBC of triclosan with Gantrez ranged from <0.3-10.4 microg/mL. The addition of Gantrez enhanced the bactericidal activity of triclosan. Both triclosan and triclosan with Gantrez demonstrated bactericidal activity against the 5 specific endodontic pathogens. SN - 0099-2399 UR - https://www.unboundmedicine.com/medline/citation/17889698/Antimicrobial_effect_of_triclosan_and_triclosan_with_Gantrez_on_five_common_endodontic_pathogens_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0099-2399(07)00566-3 DB - PRIME DP - Unbound Medicine ER -