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Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels.
Obesity (Silver Spring). 2007 Sep; 15(9):2217-24.O

Abstract

OBJECTIVE

Recent studies have suggested that a relationship between adiponectin and sex hormone, prolactin, and insulin-like growth factor levels could be important for breast cancer risk and insulin sensitivity. Therefore, we assessed the relationship of adiponectin with plasma concentrations of estrone; estradiol; estrone sulfate; testosterone; androstenedione; dehydroepiandrosterone (DHEA); dehydroepiandrosterone sulfate (DHEAS); sex hormone binding globulin (SHBG); prolactin; insulin-like growth factor (IGF-1); its binding protein, IGF binding protein 3 (IGFBP-3); c-peptide; and IGF binding protein 1 (IGFBP-1) among 360 postmenopausal women not taking postmenopausal hormones from the Nurses' Health Study.

RESEARCH METHODS AND PROCEDURES

Multivariate models were adjusted for physical activity, alcohol consumption, age at blood draw, age at first birth/parity, fasting status, and time of day of blood draw; a separate model was additionally adjusted for BMI at blood draw.

RESULTS

Estrogens were inversely associated with adiponectin levels; however, except for free estradiol, these associations were substantially attenuated after adjustment for BMI. Free estradiol levels were 27% lower among women in the top vs. bottom quartile of adiponectin levels. No consistent associations were observed for the androgens, prolactin, IGF-1, and IGFBP-3. However, SHBG, c-peptide, and IGFBP-1 were strongly and independently associated with adiponectin levels (r = 0.29, -0.30, 0.24, respectively).

CONCLUSION

With the exceptions of SHBG, c-peptide, and IGFBP-1, the studied analytes were modestly associated with adiponectin and the associations were, in large part, mediated by body fat.

Authors+Show Affiliations

Channing Laboratory, 181 Longwood Ave., 3rd Floor, Boston, MA 02115, USA. nhsst@channing.harvard.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17890489

Citation

Tworoger, Shelley S., et al. "Relationship of Plasma Adiponectin With Sex Hormone and Insulin-like Growth Factor Levels." Obesity (Silver Spring, Md.), vol. 15, no. 9, 2007, pp. 2217-24.
Tworoger SS, Mantzoros C, Hankinson SE. Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels. Obesity (Silver Spring). 2007;15(9):2217-24.
Tworoger, S. S., Mantzoros, C., & Hankinson, S. E. (2007). Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels. Obesity (Silver Spring, Md.), 15(9), 2217-24.
Tworoger SS, Mantzoros C, Hankinson SE. Relationship of Plasma Adiponectin With Sex Hormone and Insulin-like Growth Factor Levels. Obesity (Silver Spring). 2007;15(9):2217-24. PubMed PMID: 17890489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels. AU - Tworoger,Shelley S, AU - Mantzoros,Christos, AU - Hankinson,Susan E, PY - 2007/9/25/pubmed PY - 2008/1/11/medline PY - 2007/9/25/entrez SP - 2217 EP - 24 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 15 IS - 9 N2 - OBJECTIVE: Recent studies have suggested that a relationship between adiponectin and sex hormone, prolactin, and insulin-like growth factor levels could be important for breast cancer risk and insulin sensitivity. Therefore, we assessed the relationship of adiponectin with plasma concentrations of estrone; estradiol; estrone sulfate; testosterone; androstenedione; dehydroepiandrosterone (DHEA); dehydroepiandrosterone sulfate (DHEAS); sex hormone binding globulin (SHBG); prolactin; insulin-like growth factor (IGF-1); its binding protein, IGF binding protein 3 (IGFBP-3); c-peptide; and IGF binding protein 1 (IGFBP-1) among 360 postmenopausal women not taking postmenopausal hormones from the Nurses' Health Study. RESEARCH METHODS AND PROCEDURES: Multivariate models were adjusted for physical activity, alcohol consumption, age at blood draw, age at first birth/parity, fasting status, and time of day of blood draw; a separate model was additionally adjusted for BMI at blood draw. RESULTS: Estrogens were inversely associated with adiponectin levels; however, except for free estradiol, these associations were substantially attenuated after adjustment for BMI. Free estradiol levels were 27% lower among women in the top vs. bottom quartile of adiponectin levels. No consistent associations were observed for the androgens, prolactin, IGF-1, and IGFBP-3. However, SHBG, c-peptide, and IGFBP-1 were strongly and independently associated with adiponectin levels (r = 0.29, -0.30, 0.24, respectively). CONCLUSION: With the exceptions of SHBG, c-peptide, and IGFBP-1, the studied analytes were modestly associated with adiponectin and the associations were, in large part, mediated by body fat. SN - 1930-7381 UR - https://www.unboundmedicine.com/medline/citation/17890489/Relationship_of_plasma_adiponectin_with_sex_hormone_and_insulin_like_growth_factor_levels_ L2 - https://doi.org/10.1038/oby.2007.263 DB - PRIME DP - Unbound Medicine ER -