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Investigation of hypromellose particle size effects on drug release from sustained release hydrophilic matrix tablets.
Drug Dev Ind Pharm. 2007 Sep; 33(9):952-8.DD

Abstract

Selected combinations of six model drugs and four hypromellose (USP 2208) viscosity grades were studied utilizing direct compression and in vitro dissolution testing. Experimental HPMC samples with differing particle size distributions (coarse, fine, narrow, bimodal) were generated by sieving. For some formulations, the impact of HPMC particle size changes was characterized by faster drug release and an apparent shift in drug release mechanism when less than 50% of the HPMC passed through a 230 mesh (63 microm) screen. Within the ranges studied, drug release from other formulations appeared to be unaffected by HPMC particle size changes.

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Publisher Full Text

Authors+Show Affiliations

Mitchell SA
Water Soluble Polymers, The Dow Chemical Company, Midland, MI 48674, USA. samitchell@dow.com
Balwinski KM
No affiliation info available

MeSH

AcetaminophenCaffeineChemistry, PharmaceuticalDelayed-Action PreparationsDrug CarriersExcipientsHydrochlorothiazideHypromellose DerivativesKetoprofenMethylcelluloseMetoprololMolecular WeightParticle SizeSolubilityTabletsTheophyllineViscosity

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17891581

Citation

Mitchell, Shawn A., and Karen M. Balwinski. "Investigation of Hypromellose Particle Size Effects On Drug Release From Sustained Release Hydrophilic Matrix Tablets." Drug Development and Industrial Pharmacy, vol. 33, no. 9, 2007, pp. 952-8.
Mitchell SA, Balwinski KM. Investigation of hypromellose particle size effects on drug release from sustained release hydrophilic matrix tablets. Drug Dev Ind Pharm. 2007;33(9):952-8.
Mitchell, S. A., & Balwinski, K. M. (2007). Investigation of hypromellose particle size effects on drug release from sustained release hydrophilic matrix tablets. Drug Development and Industrial Pharmacy, 33(9), 952-8.
Mitchell SA, Balwinski KM. Investigation of Hypromellose Particle Size Effects On Drug Release From Sustained Release Hydrophilic Matrix Tablets. Drug Dev Ind Pharm. 2007;33(9):952-8. PubMed PMID: 17891581.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of hypromellose particle size effects on drug release from sustained release hydrophilic matrix tablets. AU - Mitchell,Shawn A, AU - Balwinski,Karen M, PY - 2007/9/25/pubmed PY - 2008/1/11/medline PY - 2007/9/25/entrez SP - 952 EP - 8 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 33 IS - 9 N2 - Selected combinations of six model drugs and four hypromellose (USP 2208) viscosity grades were studied utilizing direct compression and in vitro dissolution testing. Experimental HPMC samples with differing particle size distributions (coarse, fine, narrow, bimodal) were generated by sieving. For some formulations, the impact of HPMC particle size changes was characterized by faster drug release and an apparent shift in drug release mechanism when less than 50% of the HPMC passed through a 230 mesh (63 microm) screen. Within the ranges studied, drug release from other formulations appeared to be unaffected by HPMC particle size changes. SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/17891581/Investigation_of_hypromellose_particle_size_effects_on_drug_release_from_sustained_release_hydrophilic_matrix_tablets_ L2 - https://www.tandfonline.com/doi/full/10.1080/03639040601134132 DB - PRIME DP - Unbound Medicine ER -