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A pilot study to assess the immunologic and virologic efficacy of generic nevirapine, zidovudine and lamivudine in the treatment of HIV-1 infected women with pre-exposure to single dose nevirapine or short course zidovudine and their spouses in Chitungwiza, Zimbabwe.
Cent Afr J Med. 2006 Jan-Feb; 52(1-2):1-8.CA

Abstract

OBJECTIVE

A pilot study to assess effectiveness of generic Nevirapine (NVP)+Zidovudine (AZT)+Lamivudine (3TC) as potent antiretroviral therapy (ART) in women exposed to either SD NVP or short course (SC) AZT through participation in prevention of mother-to-child transmission of HIV-1 (pMTCT) interventions, and their spouses.

DESIGN

A pilot study of antiretroviral treatment of adults with AIDS.

SETTING

Primary health care clinics; Seke North and St Mary's in Chitungwiza, Zimbabwe.

SUBJECTS

Women with pre-exposure to SD NVP or SC AZT and their spouses with CD4 count < 200 cells/

INTERVENTIONS

Generic AZT/3TC twice daily plus NVP daily for the first 14 days and then twice a day thereafter, administered to the cohort.

MAIN OUTCOME MEASURES

The baseline median CD4 count for women and men was 128.5 and 119.0 cells/ microL respectively. The geomean virus load was similar for the women and men. At weeks 16, 24 and 48, 82.8%, 85.1% and 73.8% had < 400 copies/ml of HIV RNA respectively. Only at 16 weeks, was the proportion of women (75.9%) with undetectable virus significantly lower than that for men (93.9%), p = 0.031. Median CD4 count for both men and women increased significantly, p < 0.001. There were no significant differences in virologic responses between the women with pre-exposure to SD NVP and SC AZT. The mean adherence for women and men was similar, > 98%.

CONCLUSION

Women showed a significantly reduced response top ART relative to men only at 16. However, prior exposure to SD NVP for PMTCT was no more likely to negatively influence responses to ART than use of SC AZT.

Authors+Show Affiliations

Department of Immunology, College of Health Sciences, University of Zimbabwe, Mazoe Street, P O Box A 178, Avondale, Harare, Zimbabwe. lzijenah@healthnet.zwNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17892232

Citation

Zijenah, L S., et al. "A Pilot Study to Assess the Immunologic and Virologic Efficacy of Generic Nevirapine, Zidovudine and Lamivudine in the Treatment of HIV-1 Infected Women With Pre-exposure to Single Dose Nevirapine or Short Course Zidovudine and Their Spouses in Chitungwiza, Zimbabwe." The Central African Journal of Medicine, vol. 52, no. 1-2, 2006, pp. 1-8.
Zijenah LS, Kadzirange G, Rusakaniko S, et al. A pilot study to assess the immunologic and virologic efficacy of generic nevirapine, zidovudine and lamivudine in the treatment of HIV-1 infected women with pre-exposure to single dose nevirapine or short course zidovudine and their spouses in Chitungwiza, Zimbabwe. Cent Afr J Med. 2006;52(1-2):1-8.
Zijenah, L. S., Kadzirange, G., Rusakaniko, S., Kufa, T., Gonah, N., Tobaiwa, O., Gwanzura, C., Matsikire, E., & Katzenstein, D. A. (2006). A pilot study to assess the immunologic and virologic efficacy of generic nevirapine, zidovudine and lamivudine in the treatment of HIV-1 infected women with pre-exposure to single dose nevirapine or short course zidovudine and their spouses in Chitungwiza, Zimbabwe. The Central African Journal of Medicine, 52(1-2), 1-8.
Zijenah LS, et al. A Pilot Study to Assess the Immunologic and Virologic Efficacy of Generic Nevirapine, Zidovudine and Lamivudine in the Treatment of HIV-1 Infected Women With Pre-exposure to Single Dose Nevirapine or Short Course Zidovudine and Their Spouses in Chitungwiza, Zimbabwe. Cent Afr J Med. 2006 Jan-Feb;52(1-2):1-8. PubMed PMID: 17892232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A pilot study to assess the immunologic and virologic efficacy of generic nevirapine, zidovudine and lamivudine in the treatment of HIV-1 infected women with pre-exposure to single dose nevirapine or short course zidovudine and their spouses in Chitungwiza, Zimbabwe. AU - Zijenah,L S, AU - Kadzirange,G, AU - Rusakaniko,S, AU - Kufa,T, AU - Gonah,N, AU - Tobaiwa,O, AU - Gwanzura,C, AU - Matsikire,E, AU - Katzenstein,D A, PY - 2007/9/26/pubmed PY - 2007/10/19/medline PY - 2007/9/26/entrez SP - 1 EP - 8 JF - The Central African journal of medicine JO - Cent Afr J Med VL - 52 IS - 1-2 N2 - OBJECTIVE: A pilot study to assess effectiveness of generic Nevirapine (NVP)+Zidovudine (AZT)+Lamivudine (3TC) as potent antiretroviral therapy (ART) in women exposed to either SD NVP or short course (SC) AZT through participation in prevention of mother-to-child transmission of HIV-1 (pMTCT) interventions, and their spouses. DESIGN: A pilot study of antiretroviral treatment of adults with AIDS. SETTING: Primary health care clinics; Seke North and St Mary's in Chitungwiza, Zimbabwe. SUBJECTS: Women with pre-exposure to SD NVP or SC AZT and their spouses with CD4 count < 200 cells/ INTERVENTIONS: Generic AZT/3TC twice daily plus NVP daily for the first 14 days and then twice a day thereafter, administered to the cohort. MAIN OUTCOME MEASURES: The baseline median CD4 count for women and men was 128.5 and 119.0 cells/ microL respectively. The geomean virus load was similar for the women and men. At weeks 16, 24 and 48, 82.8%, 85.1% and 73.8% had < 400 copies/ml of HIV RNA respectively. Only at 16 weeks, was the proportion of women (75.9%) with undetectable virus significantly lower than that for men (93.9%), p = 0.031. Median CD4 count for both men and women increased significantly, p < 0.001. There were no significant differences in virologic responses between the women with pre-exposure to SD NVP and SC AZT. The mean adherence for women and men was similar, > 98%. CONCLUSION: Women showed a significantly reduced response top ART relative to men only at 16. However, prior exposure to SD NVP for PMTCT was no more likely to negatively influence responses to ART than use of SC AZT. SN - 0008-9176 UR - https://www.unboundmedicine.com/medline/citation/17892232/A_pilot_study_to_assess_the_immunologic_and_virologic_efficacy_of_generic_nevirapine_zidovudine_and_lamivudine_in_the_treatment_of_HIV_1_infected_women_with_pre_exposure_to_single_dose_nevirapine_or_short_course_zidovudine_and_their_spouses_in_Chitungwiza_Zimbabwe_ L2 - http://www.diseaseinfosearch.org/result/9735 DB - PRIME DP - Unbound Medicine ER -