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Management of hostile, suspicious patients. Trifluoperazine versus haloperidol.
Dis Nerv Syst. 1974 Feb; 35(2):75-8.DN

Abstract

In a population of hostile suspicious patients mostly fitting into the paranoid schizophrenic category, haloperidol and trifluoperazine when compared in double-blind fashion were equal in global clinical ratings. Haloperidol showed significantly more improvement on the Brief Psychiatric Rating Scale and on the Global Paranoia rating. On the Global Hostility rating and in speed of onset of activity, the effects of the two drugs were not significantly different. In a small sub-sample of extremely uncooperative patients haloperidol showed marked effects, but trifluoperazine showed only minimal or moderate effects.

Authors+Show Affiliations

O'Brien CP
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
DiGiacomo JN
No affiliation info available
Webb W
No affiliation info available

MeSH

AdultAntipsychotic AgentsDisruptive, Impulse Control, and Conduct DisordersDouble-Blind MethodFemaleHaloperidolHostilityHumansMaleMiddle AgedParanoid DisordersPsychiatric Status Rating ScalesSchizophrenia, ParanoidTreatment OutcomeTrifluoperazine

Pub Type(s)

Controlled Clinical Trial
Journal Article
Multicenter Study

Language

eng

PubMed ID

17894044

Citation

O'Brien, C P., et al. "Management of Hostile, Suspicious Patients. Trifluoperazine Versus Haloperidol." Diseases of the Nervous System, vol. 35, no. 2, 1974, pp. 75-8.
O'Brien CP, DiGiacomo JN, Webb W. Management of hostile, suspicious patients. Trifluoperazine versus haloperidol. Dis Nerv Syst. 1974;35(2):75-8.
O'Brien, C. P., DiGiacomo, J. N., & Webb, W. (1974). Management of hostile, suspicious patients. Trifluoperazine versus haloperidol. Diseases of the Nervous System, 35(2), 75-8.
O'Brien CP, DiGiacomo JN, Webb W. Management of Hostile, Suspicious Patients. Trifluoperazine Versus Haloperidol. Dis Nerv Syst. 1974;35(2):75-8. PubMed PMID: 17894044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Management of hostile, suspicious patients. Trifluoperazine versus haloperidol. AU - O'Brien,C P, AU - DiGiacomo,J N, AU - Webb,W, PY - 1974/2/1/pubmed PY - 2007/10/11/medline PY - 1974/2/1/entrez SP - 75 EP - 8 JF - Diseases of the nervous system JO - Dis Nerv Syst VL - 35 IS - 2 N2 - In a population of hostile suspicious patients mostly fitting into the paranoid schizophrenic category, haloperidol and trifluoperazine when compared in double-blind fashion were equal in global clinical ratings. Haloperidol showed significantly more improvement on the Brief Psychiatric Rating Scale and on the Global Paranoia rating. On the Global Hostility rating and in speed of onset of activity, the effects of the two drugs were not significantly different. In a small sub-sample of extremely uncooperative patients haloperidol showed marked effects, but trifluoperazine showed only minimal or moderate effects. SN - 0012-3714 UR - https://www.unboundmedicine.com/medline/citation/17894044/Management_of_hostile_suspicious_patients__Trifluoperazine_versus_haloperidol_ DB - PRIME DP - Unbound Medicine ER -