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Hereditary thrombophilic risk factors and venous thromboembolism in Istanbul, Turkey: the role in different clinical manifestations of venous thromboembolism.
Clin Appl Thromb Hemost. 2008 Apr; 14(2):168-73.CA

Abstract

The aim of this study was to investigate the hereditary thrombophilic risk factors in patients with venous thromboembolism (VTE) and whether these risk factors play a different role in patients with isolated pulmonary embolism (PE) as compared with patients with deep vein thrombosis (DVT) and patients with PE + DVT. The protein C (PC), protein S, antithrombin activities, homocysteine levels, and factor V Leiden (FVL) G1691A and prothrombin G20210A mutations were evaluated in 191 patients with VTE and 191 controls. The prevalence of FVL and PC deficiency were higher in patients (P = .003 and P = .02, respectively). There was no significant difference for the other risk factors. The combination of thrombophilic risk factors was significantly higher in patients with DVT + PE as compared with patients with isolated PE or DVT (P = .04). In conclusion, the most important hereditary risk factors for VTE in this study were the FVL mutation and PC deficiency.

Authors+Show Affiliations

Department of Pulmonary Diseases, Istanbul Medical Faculty, Istanbul University, Capa-Istanbul, Turkey. gulferokumus@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17895505

Citation

Okumus, Gulfer, et al. "Hereditary Thrombophilic Risk Factors and Venous Thromboembolism in Istanbul, Turkey: the Role in Different Clinical Manifestations of Venous Thromboembolism." Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, vol. 14, no. 2, 2008, pp. 168-73.
Okumus G, Kiyan E, Arseven O, et al. Hereditary thrombophilic risk factors and venous thromboembolism in Istanbul, Turkey: the role in different clinical manifestations of venous thromboembolism. Clin Appl Thromb Hemost. 2008;14(2):168-73.
Okumus, G., Kiyan, E., Arseven, O., Tabak, L., Diz-Kucukkaya, R., Unlucerci, Y., Abaci, N., Unaltuna, N. E., & Issever, H. (2008). Hereditary thrombophilic risk factors and venous thromboembolism in Istanbul, Turkey: the role in different clinical manifestations of venous thromboembolism. Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 14(2), 168-73.
Okumus G, et al. Hereditary Thrombophilic Risk Factors and Venous Thromboembolism in Istanbul, Turkey: the Role in Different Clinical Manifestations of Venous Thromboembolism. Clin Appl Thromb Hemost. 2008;14(2):168-73. PubMed PMID: 17895505.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hereditary thrombophilic risk factors and venous thromboembolism in Istanbul, Turkey: the role in different clinical manifestations of venous thromboembolism. AU - Okumus,Gulfer, AU - Kiyan,Esen, AU - Arseven,Orhan, AU - Tabak,Levent, AU - Diz-Kucukkaya,Reyhan, AU - Unlucerci,Yesim, AU - Abaci,Neslihan, AU - Unaltuna,Nihan Erginel, AU - Issever,Halim, Y1 - 2007/09/25/ PY - 2007/9/27/pubmed PY - 2008/5/28/medline PY - 2007/9/27/entrez SP - 168 EP - 73 JF - Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis JO - Clin Appl Thromb Hemost VL - 14 IS - 2 N2 - The aim of this study was to investigate the hereditary thrombophilic risk factors in patients with venous thromboembolism (VTE) and whether these risk factors play a different role in patients with isolated pulmonary embolism (PE) as compared with patients with deep vein thrombosis (DVT) and patients with PE + DVT. The protein C (PC), protein S, antithrombin activities, homocysteine levels, and factor V Leiden (FVL) G1691A and prothrombin G20210A mutations were evaluated in 191 patients with VTE and 191 controls. The prevalence of FVL and PC deficiency were higher in patients (P = .003 and P = .02, respectively). There was no significant difference for the other risk factors. The combination of thrombophilic risk factors was significantly higher in patients with DVT + PE as compared with patients with isolated PE or DVT (P = .04). In conclusion, the most important hereditary risk factors for VTE in this study were the FVL mutation and PC deficiency. SN - 1076-0296 UR - https://www.unboundmedicine.com/medline/citation/17895505/Hereditary_thrombophilic_risk_factors_and_venous_thromboembolism_in_Istanbul_Turkey:_the_role_in_different_clinical_manifestations_of_venous_thromboembolism_ L2 - https://journals.sagepub.com/doi/10.1177/1076029607305620?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -