Tags

Type your tag names separated by a space and hit enter

[Insulin infusion for critically ill patients].
Tidsskr Nor Laegeforen. 2007 Sep 20; 127(18):2378-81.TN

Abstract

BACKGROUND

Stress, acute illness and surgery are known to increase blood sugar. Hyperglycaemia in critically ill patients is associated with increased mortality irrespective of diabetes status. The effect of treating critically ill patients with insulin infusions has been assessed in many randomised trials in recent years. Possible mechanisms related to hyperglycaemia and the effects of insulin have also been studied.

MATERIAL AND METHODS

The present review is based on a systematic Medline search, references in key articles, and our personal clinical experience.

RESULTS

The effect of reducing blood glucose to normal levels is best documented in patients with myocardial infarction and in those receiving intensive care. Insulin therapy should be considered when plasma glucose levels exceed 8 mmol/L; the treatment target is 4-6 mmol/L. There is a low risk of serious hypoglycaemia according to our experience, but systematic monitoring of blood glucose is important.

INTERPRETATION

Insulin therapy is an inexpensive and safe way to improve outcome in critically ill patients. Insulin infusions should therefore be used more to treat hyperglycaemia in critically ill hospitalized patients, especially in coronary care- and intensive care units.

Authors+Show Affiliations

Endokrinologisk seksjon, Medisinsk klinikk, Stavanger universitetssjukehus, Postboks 8100, 4068 Stavanger. sksv@sus.noNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

nor

PubMed ID

17895943

Citation

Skeie, Svein, et al. "[Insulin Infusion for Critically Ill Patients]." Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, vol. 127, no. 18, 2007, pp. 2378-81.
Skeie S, Søreide E, Cooper J. [Insulin infusion for critically ill patients]. Tidsskr Nor Laegeforen. 2007;127(18):2378-81.
Skeie, S., Søreide, E., & Cooper, J. (2007). [Insulin infusion for critically ill patients]. Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, 127(18), 2378-81.
Skeie S, Søreide E, Cooper J. [Insulin Infusion for Critically Ill Patients]. Tidsskr Nor Laegeforen. 2007 Sep 20;127(18):2378-81. PubMed PMID: 17895943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Insulin infusion for critically ill patients]. AU - Skeie,Svein, AU - Søreide,Eldar, AU - Cooper,John, PY - 2007/9/27/pubmed PY - 2007/10/19/medline PY - 2007/9/27/entrez SP - 2378 EP - 81 JF - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke JO - Tidsskr Nor Laegeforen VL - 127 IS - 18 N2 - BACKGROUND: Stress, acute illness and surgery are known to increase blood sugar. Hyperglycaemia in critically ill patients is associated with increased mortality irrespective of diabetes status. The effect of treating critically ill patients with insulin infusions has been assessed in many randomised trials in recent years. Possible mechanisms related to hyperglycaemia and the effects of insulin have also been studied. MATERIAL AND METHODS: The present review is based on a systematic Medline search, references in key articles, and our personal clinical experience. RESULTS: The effect of reducing blood glucose to normal levels is best documented in patients with myocardial infarction and in those receiving intensive care. Insulin therapy should be considered when plasma glucose levels exceed 8 mmol/L; the treatment target is 4-6 mmol/L. There is a low risk of serious hypoglycaemia according to our experience, but systematic monitoring of blood glucose is important. INTERPRETATION: Insulin therapy is an inexpensive and safe way to improve outcome in critically ill patients. Insulin infusions should therefore be used more to treat hyperglycaemia in critically ill hospitalized patients, especially in coronary care- and intensive care units. SN - 0807-7096 UR - https://www.unboundmedicine.com/medline/citation/17895943/[Insulin_infusion_for_critically_ill_patients]_ L2 - http://tidsskriftet.no/article/1584891 DB - PRIME DP - Unbound Medicine ER -