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First and third trimester ultrasound in the prediction of birthweight discordance in dichorionic twins.
Eur J Obstet Gynecol Reprod Biol. 2008 May; 138(1):34-8.EJ

Abstract

OBJECTIVE

Birthweight discordance amongst twins is associated with an increase in perinatal morbidity and mortality. Clinical decisions regarding the management of twins are often made on the basis of estimated fetal weight in the third trimester. This study assesses the efficacy of routine third trimester ultrasound fetal biometry, third trimester fetal growth velocity and first trimester differences in size in the prediction of subsequent birthweight discordance.

STUDY DESIGN

Structurally and chromosomally normal dichorionic twin gestations resulting in two live births after 24 weeks gestation were identified. Ultrasound examinations of dichorionic twin pregnancies between 10 and 14 weeks of gestation were evaluated for inter-twin biometric disparity in crown-rump length (CRL). Estimated fetal weight (EFW) was calculated from the last scan before delivery. Fetal growth velocity (FGV) was calculated from two estimates of fetal weight between 21 and 35 days apart and incorporating the last EFW before delivery. EFW and FGV were expressed as standard deviation scores (Z scores). Disparity between these ultrasound parameters was correlated to inter-twin birthweight difference. Birthweight discordance was defined as > or =20% difference in birthweight relative to the heavier twin. Fishers exact and Spearman rho tests were used for statistical analysis. Test performance is expressed as area under the ROC curve and likelihood ratios (LR).

RESULTS

One hundred and thirty-five dichorionic gestations were identified over a consecutive 3-year-period. One hundred and eight twin gestations had both crown-rump length (CRL) and sufficient ultrasound measurements in the third trimester to calculate FGV. Twenty-six pregnancies (24%) had discordant birthweight. Only EFW Z score difference was correlated with birthweight disparity (r=0.36, p = <0.001). An EFW Z score difference of 0.6 had an area under the ROC curve of 0.70 (95% C.I. 0.59-0.79) but this did not differ significantly from first trimester prediction of growth discordance which had an area of 0.55 (95% C.I. 0.44-0.66). The LR for first and third trimester prediction of discordance were low.

CONCLUSION

Ultrasound measurement of fetal growth velocity and size both in the first and third trimesters is a poor predictor of birthweight discordance. Disparate fetal growth is exhibited as early as 10-14 weeks gestation and differences at this early stage in fetal development are no less accurate than EFW within 1 month of delivery. First trimester ultrasound, third trimester growth velocity and third trimester EFW do not accurately predict the delivery of twins with discordant birthweight.

Authors+Show Affiliations

Department of Obstetrics & Gynaecology, Princess Royal Maternity Unit, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17897772

Citation

Banks, Claire L., et al. "First and Third Trimester Ultrasound in the Prediction of Birthweight Discordance in Dichorionic Twins." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 138, no. 1, 2008, pp. 34-8.
Banks CL, Nelson SM, Owen P. First and third trimester ultrasound in the prediction of birthweight discordance in dichorionic twins. Eur J Obstet Gynecol Reprod Biol. 2008;138(1):34-8.
Banks, C. L., Nelson, S. M., & Owen, P. (2008). First and third trimester ultrasound in the prediction of birthweight discordance in dichorionic twins. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 138(1), 34-8.
Banks CL, Nelson SM, Owen P. First and Third Trimester Ultrasound in the Prediction of Birthweight Discordance in Dichorionic Twins. Eur J Obstet Gynecol Reprod Biol. 2008;138(1):34-8. PubMed PMID: 17897772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - First and third trimester ultrasound in the prediction of birthweight discordance in dichorionic twins. AU - Banks,Claire L, AU - Nelson,Scott M, AU - Owen,Philip, Y1 - 2007/09/25/ PY - 2006/08/15/received PY - 2007/04/26/revised PY - 2007/08/07/accepted PY - 2007/9/28/pubmed PY - 2008/9/16/medline PY - 2007/9/28/entrez SP - 34 EP - 8 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur. J. Obstet. Gynecol. Reprod. Biol. VL - 138 IS - 1 N2 - OBJECTIVE: Birthweight discordance amongst twins is associated with an increase in perinatal morbidity and mortality. Clinical decisions regarding the management of twins are often made on the basis of estimated fetal weight in the third trimester. This study assesses the efficacy of routine third trimester ultrasound fetal biometry, third trimester fetal growth velocity and first trimester differences in size in the prediction of subsequent birthweight discordance. STUDY DESIGN: Structurally and chromosomally normal dichorionic twin gestations resulting in two live births after 24 weeks gestation were identified. Ultrasound examinations of dichorionic twin pregnancies between 10 and 14 weeks of gestation were evaluated for inter-twin biometric disparity in crown-rump length (CRL). Estimated fetal weight (EFW) was calculated from the last scan before delivery. Fetal growth velocity (FGV) was calculated from two estimates of fetal weight between 21 and 35 days apart and incorporating the last EFW before delivery. EFW and FGV were expressed as standard deviation scores (Z scores). Disparity between these ultrasound parameters was correlated to inter-twin birthweight difference. Birthweight discordance was defined as > or =20% difference in birthweight relative to the heavier twin. Fishers exact and Spearman rho tests were used for statistical analysis. Test performance is expressed as area under the ROC curve and likelihood ratios (LR). RESULTS: One hundred and thirty-five dichorionic gestations were identified over a consecutive 3-year-period. One hundred and eight twin gestations had both crown-rump length (CRL) and sufficient ultrasound measurements in the third trimester to calculate FGV. Twenty-six pregnancies (24%) had discordant birthweight. Only EFW Z score difference was correlated with birthweight disparity (r=0.36, p = <0.001). An EFW Z score difference of 0.6 had an area under the ROC curve of 0.70 (95% C.I. 0.59-0.79) but this did not differ significantly from first trimester prediction of growth discordance which had an area of 0.55 (95% C.I. 0.44-0.66). The LR for first and third trimester prediction of discordance were low. CONCLUSION: Ultrasound measurement of fetal growth velocity and size both in the first and third trimesters is a poor predictor of birthweight discordance. Disparate fetal growth is exhibited as early as 10-14 weeks gestation and differences at this early stage in fetal development are no less accurate than EFW within 1 month of delivery. First trimester ultrasound, third trimester growth velocity and third trimester EFW do not accurately predict the delivery of twins with discordant birthweight. SN - 0301-2115 UR - https://www.unboundmedicine.com/medline/citation/17897772/First_and_third_trimester_ultrasound_in_the_prediction_of_birthweight_discordance_in_dichorionic_twins_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(07)00354-5 DB - PRIME DP - Unbound Medicine ER -