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Impaired cortical and autonomic arousal during sleep in multiple system atrophy.
Clin Neurophysiol. 2007 Nov; 118(11):2512-8.CN

Abstract

OBJECTIVE

Periodic limb movements during sleep (PLMS) in Restless Legs Syndrome (RLS) are associated with arousals and stereotyped EEG and heart rate (HR) changes. We investigated PLMS-related EEG and HR variations in multiple system atrophy (MSA) in order to detect possible abnormalities in cortical and autonomic arousal responses.

METHODS

Ten patients with MSA were contrasted against ten patients with primary RLS. Cortical (EEG) and autonomic (HR) variations associated with PLMS during NREM sleep were analysed by means of Fast Fourier Transform and HR analysis. In addition, we analysed the cyclic alternating pattern (CAP) during sleep, CAP representing a measure of the spontaneous arousal oscillations during NREM sleep.

RESULTS

PLMS in RLS were associated with tachycardia and spectral EEG variations, beginning about 2s before the onset of PLMS, and peaking 1-4s after. The HR and spectral EEG variations were strikingly reduced or absent in MSA. MSA patients also had significantly lower CAP rate compared to RLS patients.

CONCLUSIONS

Blunted HR and EEG spectral changes adjacent to PLMS indicated impaired cortical and autonomic arousal responses during sleep in MSA patients.

SIGNIFICANCE

PLMS, when present, may represent a useful means to study the arousal responses during sleep.

Authors+Show Affiliations

Department of Neurological Sciences, University of Bologna, Via Ugo Foscolo 7, 40123 Bologna, Italy. vetrugno@neuro.unibo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17897876

Citation

Vetrugno, Roberto, et al. "Impaired Cortical and Autonomic Arousal During Sleep in Multiple System Atrophy." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 118, no. 11, 2007, pp. 2512-8.
Vetrugno R, D'Angelo R, Cortelli P, et al. Impaired cortical and autonomic arousal during sleep in multiple system atrophy. Clin Neurophysiol. 2007;118(11):2512-8.
Vetrugno, R., D'Angelo, R., Cortelli, P., Plazzi, G., Vignatelli, L., & Montagna, P. (2007). Impaired cortical and autonomic arousal during sleep in multiple system atrophy. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 118(11), 2512-8.
Vetrugno R, et al. Impaired Cortical and Autonomic Arousal During Sleep in Multiple System Atrophy. Clin Neurophysiol. 2007;118(11):2512-8. PubMed PMID: 17897876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impaired cortical and autonomic arousal during sleep in multiple system atrophy. AU - Vetrugno,Roberto, AU - D'Angelo,Roberto, AU - Cortelli,Pietro, AU - Plazzi,Giuseppe, AU - Vignatelli,Luca, AU - Montagna,Pasquale, Y1 - 2007/09/25/ PY - 2007/05/23/received PY - 2007/07/30/revised PY - 2007/08/23/accepted PY - 2007/9/28/pubmed PY - 2008/2/13/medline PY - 2007/9/28/entrez SP - 2512 EP - 8 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 118 IS - 11 N2 - OBJECTIVE: Periodic limb movements during sleep (PLMS) in Restless Legs Syndrome (RLS) are associated with arousals and stereotyped EEG and heart rate (HR) changes. We investigated PLMS-related EEG and HR variations in multiple system atrophy (MSA) in order to detect possible abnormalities in cortical and autonomic arousal responses. METHODS: Ten patients with MSA were contrasted against ten patients with primary RLS. Cortical (EEG) and autonomic (HR) variations associated with PLMS during NREM sleep were analysed by means of Fast Fourier Transform and HR analysis. In addition, we analysed the cyclic alternating pattern (CAP) during sleep, CAP representing a measure of the spontaneous arousal oscillations during NREM sleep. RESULTS: PLMS in RLS were associated with tachycardia and spectral EEG variations, beginning about 2s before the onset of PLMS, and peaking 1-4s after. The HR and spectral EEG variations were strikingly reduced or absent in MSA. MSA patients also had significantly lower CAP rate compared to RLS patients. CONCLUSIONS: Blunted HR and EEG spectral changes adjacent to PLMS indicated impaired cortical and autonomic arousal responses during sleep in MSA patients. SIGNIFICANCE: PLMS, when present, may represent a useful means to study the arousal responses during sleep. SN - 1388-2457 UR - https://www.unboundmedicine.com/medline/citation/17897876/Impaired_cortical_and_autonomic_arousal_during_sleep_in_multiple_system_atrophy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(07)00424-5 DB - PRIME DP - Unbound Medicine ER -