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Pos-infectious bronchiolitis obliterans in children.
Rev Port Pneumol 2007 Jul-Aug; 13(4):495-509RP

Abstract

Bronchiolitis obliterans (BO) is a rare disease in immunocompetent children that usually occurs after infection of the lower airways. While a diagnosis of BO was usually confirmed by lung biopsy, identification of prior lung lesion plus a typical clinical course and a suggestive chest X-ray and CT scan have replaced the need for more invasive procedures. The authors reviewed the clinical records of 10 BO patients, followed in the Outpatients Paediatric Pulmonology Unit from January 1997 to December 2002, to identify the most common aetiology, clinical and radiological profiles, treatment and course. All patients maintained cough and/or wheezing after the initial acute episode. 80% had failure to thrive at the time of the diagnosis, mean age 16 months. Viral pneumonia was the main initial event (5 adenovirus, 3 respiratory syncytial virus, 1 parainfluenza virus, 1 unknown). Lung biopsies were not performed as clinical and radiological presentations were typical of BO. The follow-up (mean 36 months) revealed clinical resolution in 3 children and persistent symptoms in 6. One patient had progressive respiratory failure and died. Prompt recognition of the diagnosis with supportive treatment that included oxygen therapy and an aggressive nutrition plan helped to improve the clinical state of the children.

Authors+Show Affiliations

Paediatric Unit, Hospital Padre Américo-Vale do Sousa, Lugar do Tapadinho, 4560-162 Guilhufe Penafiel. analobo@sapo.pltNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng por

PubMed ID

17898910

Citation

Lobo, Ana Luísa, et al. "Pos-infectious Bronchiolitis Obliterans in Children." Revista Portuguesa De Pneumologia, vol. 13, no. 4, 2007, pp. 495-509.
Lobo AL, Guardiano M, Nunes T, et al. Pos-infectious bronchiolitis obliterans in children. Rev Port Pneumol. 2007;13(4):495-509.
Lobo, A. L., Guardiano, M., Nunes, T., Azevedo, I., & Vaz, L. G. (2007). Pos-infectious bronchiolitis obliterans in children. Revista Portuguesa De Pneumologia, 13(4), pp. 495-509.
Lobo AL, et al. Pos-infectious Bronchiolitis Obliterans in Children. Rev Port Pneumol. 2007;13(4):495-509. PubMed PMID: 17898910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pos-infectious bronchiolitis obliterans in children. AU - Lobo,Ana Luísa, AU - Guardiano,Micaela, AU - Nunes,Teresa, AU - Azevedo,Inês, AU - Vaz,Luísa Guedes, PY - 2007/9/28/pubmed PY - 2007/12/7/medline PY - 2007/9/28/entrez SP - 495 EP - 509 JF - Revista portuguesa de pneumologia JO - Rev Port Pneumol VL - 13 IS - 4 N2 - Bronchiolitis obliterans (BO) is a rare disease in immunocompetent children that usually occurs after infection of the lower airways. While a diagnosis of BO was usually confirmed by lung biopsy, identification of prior lung lesion plus a typical clinical course and a suggestive chest X-ray and CT scan have replaced the need for more invasive procedures. The authors reviewed the clinical records of 10 BO patients, followed in the Outpatients Paediatric Pulmonology Unit from January 1997 to December 2002, to identify the most common aetiology, clinical and radiological profiles, treatment and course. All patients maintained cough and/or wheezing after the initial acute episode. 80% had failure to thrive at the time of the diagnosis, mean age 16 months. Viral pneumonia was the main initial event (5 adenovirus, 3 respiratory syncytial virus, 1 parainfluenza virus, 1 unknown). Lung biopsies were not performed as clinical and radiological presentations were typical of BO. The follow-up (mean 36 months) revealed clinical resolution in 3 children and persistent symptoms in 6. One patient had progressive respiratory failure and died. Prompt recognition of the diagnosis with supportive treatment that included oxygen therapy and an aggressive nutrition plan helped to improve the clinical state of the children. SN - 0873-2159 UR - https://www.unboundmedicine.com/medline/citation/17898910/Pos_infectious_bronchiolitis_obliterans_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0873-2159(15)30361-5 DB - PRIME DP - Unbound Medicine ER -