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Selective breeding of reduced sensorimotor gating in Wistar rats.
Behav Genet. 2007 Sep; 37(5):706-12.BG

Abstract

Prepulse inhibition (PPI) of startle is an operational measure of sensorimotor gating that is reduced in some neuropsychiatric disorders (e.g. schizophrenia). Animal models have revealed insight into the neuronal and pharmacological underpinnings of PPI-deficits. Recent work has shown that a PPI-deficit can be selectively bred in Wistar rats and is already stable in the second filial generation. We here report on developmental and parametric characteristics of sensorimotor gating deficits in the 4th and 6th filial generation of male rats selectively bred for low PPI (low PPI) compared to rats with normal levels of PPI (high PPI). Low PPI rats showed significantly reduced PPI and variable startle magnitude (in pulse alone trials) along with reduced short-term habituation of startle as adults. Reduced PPI in the low PPI rats was found throughout development (tested on postnatal days 21, 35, 49, 70). PPI-deficits in the low PPI rats were evident at prepulse intensities ranging from 62-86 dB and for interstimulus intervals ranging between 30-1000 ms. These behavioral data add to a growing body of knowledge about the genetic basis of sensorimotor gating deficits and suggest that low PPI rats have potential use as an intermediate phenotype in schizophrenia research. The stable phenotype of breeding-induced PPI-deficits and reduced startle habituation indicates that PPI has strong genetic determinants and that selectively bred rats can be used for future neurophysiological, anatomical, pharmacological, and genomic analyses.

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Authors+Show Affiliations

Schwabe K
Brain Research Institute, Department of Neuropharmacology, University of Bremen, POB 330440, 28334 Bremen, Germany.
Freudenberg F
No affiliation info available
Koch M
No affiliation info available

MeSH

Acoustic StimulationAgingAnimalsAnimals, NewbornHabituation, PsychophysiologicModels, AnimalNervous System Physiological PhenomenaRatsRats, WistarReflex, Startle

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17899353

Citation

Schwabe, Kerstin, et al. "Selective Breeding of Reduced Sensorimotor Gating in Wistar Rats." Behavior Genetics, vol. 37, no. 5, 2007, pp. 706-12.
Schwabe K, Freudenberg F, Koch M. Selective breeding of reduced sensorimotor gating in Wistar rats. Behav Genet. 2007;37(5):706-12.
Schwabe, K., Freudenberg, F., & Koch, M. (2007). Selective breeding of reduced sensorimotor gating in Wistar rats. Behavior Genetics, 37(5), 706-12.
Schwabe K, Freudenberg F, Koch M. Selective Breeding of Reduced Sensorimotor Gating in Wistar Rats. Behav Genet. 2007;37(5):706-12. PubMed PMID: 17899353.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selective breeding of reduced sensorimotor gating in Wistar rats. AU - Schwabe,Kerstin, AU - Freudenberg,Florian, AU - Koch,Michael, PY - 2007/05/30/received PY - 2007/07/31/accepted PY - 2007/9/28/pubmed PY - 2008/1/19/medline PY - 2007/9/28/entrez SP - 706 EP - 12 JF - Behavior genetics JO - Behav Genet VL - 37 IS - 5 N2 - Prepulse inhibition (PPI) of startle is an operational measure of sensorimotor gating that is reduced in some neuropsychiatric disorders (e.g. schizophrenia). Animal models have revealed insight into the neuronal and pharmacological underpinnings of PPI-deficits. Recent work has shown that a PPI-deficit can be selectively bred in Wistar rats and is already stable in the second filial generation. We here report on developmental and parametric characteristics of sensorimotor gating deficits in the 4th and 6th filial generation of male rats selectively bred for low PPI (low PPI) compared to rats with normal levels of PPI (high PPI). Low PPI rats showed significantly reduced PPI and variable startle magnitude (in pulse alone trials) along with reduced short-term habituation of startle as adults. Reduced PPI in the low PPI rats was found throughout development (tested on postnatal days 21, 35, 49, 70). PPI-deficits in the low PPI rats were evident at prepulse intensities ranging from 62-86 dB and for interstimulus intervals ranging between 30-1000 ms. These behavioral data add to a growing body of knowledge about the genetic basis of sensorimotor gating deficits and suggest that low PPI rats have potential use as an intermediate phenotype in schizophrenia research. The stable phenotype of breeding-induced PPI-deficits and reduced startle habituation indicates that PPI has strong genetic determinants and that selectively bred rats can be used for future neurophysiological, anatomical, pharmacological, and genomic analyses. SN - 0001-8244 UR - https://www.unboundmedicine.com/medline/citation/17899353/Selective_breeding_of_reduced_sensorimotor_gating_in_Wistar_rats_ L2 - https://doi.org/10.1007/s10519-007-9166-z DB - PRIME DP - Unbound Medicine ER -