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Pulmonary function correlates with body composition in Nigerian children and young adults with sickle cell disease.

Abstract

Sickle cell disease (SCD) is associated with impaired growth and skeletal maturation. Decreased fat-free mass (FFM) and body fat (BF) have been reported in Nigerian children with SCD relative to healthy age- and gender-matched controls. Pulmonary abnormalities, including reduced forced vital capacity (FVC), forced expiratory volume in one second (FEV(1)) and total lung capacity (TLC), have also been described in children with SCD. Since undernutrition is common in sub-Saharan Africa, we were interested in knowing the relationship between pulmonary function and body composition in Nigerian children and young adults with SCD. Body composition was determined using bioelectrical impedance and pulmonary function was assessed by spirometry in Nigerian children and young adults aged 7-35 years (n = 102) as well as healthy age-and gender-matched controls (n = 104). Age-adjusted data revealed 19-26% lower FFM for male (P < 0.001) and female (P < 0.001) subjects with SCD relative to the controls. FVC, FEV(1) and PEF were also significantly reduced in male and female children and young adults with SCD compared to their control counterparts. For both male and female patients and controls, FVC, FEV(1) and PEF correlated positively with FFM (P < 0.001). PEF for the female subjects with SCD diverged progressively with increasing age relative to the controls and the rate of change was significantly lower (P < 0.001). We conclude that pulmonary function is reduced in Nigerian children and young adults with SCD compared to controls and that for both groups, pulmonary function is directly related to body composition. These findings underscore the need for early nutritional intervention for children with SCD.

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  • Authors+Show Affiliations

    ,

    Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM 87131-0001, USA.

    , , , ,

    Source

    Journal of tropical pediatrics 54:2 2008 Apr pg 87-93

    MeSH

    Adolescent
    Adult
    Aging
    Anemia, Sickle Cell
    Anthropometry
    Body Composition
    Case-Control Studies
    Child
    Electric Impedance
    Female
    Forced Expiratory Flow Rates
    Humans
    Male
    Nigeria
    Regression Analysis
    Sex Factors
    Spirometry

    Pub Type(s)

    Clinical Trial
    Journal Article

    Language

    eng

    PubMed ID

    17901067

    Citation

    VanderJagt, Dorothy J., et al. "Pulmonary Function Correlates With Body Composition in Nigerian Children and Young Adults With Sickle Cell Disease." Journal of Tropical Pediatrics, vol. 54, no. 2, 2008, pp. 87-93.
    VanderJagt DJ, Trujillo MR, Jalo I, et al. Pulmonary function correlates with body composition in Nigerian children and young adults with sickle cell disease. J Trop Pediatr. 2008;54(2):87-93.
    VanderJagt, D. J., Trujillo, M. R., Jalo, I., Bode-Thomas, F., Glew, R. H., & Agaba, P. (2008). Pulmonary function correlates with body composition in Nigerian children and young adults with sickle cell disease. Journal of Tropical Pediatrics, 54(2), pp. 87-93.
    VanderJagt DJ, et al. Pulmonary Function Correlates With Body Composition in Nigerian Children and Young Adults With Sickle Cell Disease. J Trop Pediatr. 2008;54(2):87-93. PubMed PMID: 17901067.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Pulmonary function correlates with body composition in Nigerian children and young adults with sickle cell disease. AU - VanderJagt,Dorothy J, AU - Trujillo,Miguel R, AU - Jalo,Iliya, AU - Bode-Thomas,Fidelia, AU - Glew,Robert H, AU - Agaba,Patricia, Y1 - 2007/09/26/ PY - 2007/9/29/pubmed PY - 2008/5/30/medline PY - 2007/9/29/entrez SP - 87 EP - 93 JF - Journal of tropical pediatrics JO - J. Trop. Pediatr. VL - 54 IS - 2 N2 - Sickle cell disease (SCD) is associated with impaired growth and skeletal maturation. Decreased fat-free mass (FFM) and body fat (BF) have been reported in Nigerian children with SCD relative to healthy age- and gender-matched controls. Pulmonary abnormalities, including reduced forced vital capacity (FVC), forced expiratory volume in one second (FEV(1)) and total lung capacity (TLC), have also been described in children with SCD. Since undernutrition is common in sub-Saharan Africa, we were interested in knowing the relationship between pulmonary function and body composition in Nigerian children and young adults with SCD. Body composition was determined using bioelectrical impedance and pulmonary function was assessed by spirometry in Nigerian children and young adults aged 7-35 years (n = 102) as well as healthy age-and gender-matched controls (n = 104). Age-adjusted data revealed 19-26% lower FFM for male (P < 0.001) and female (P < 0.001) subjects with SCD relative to the controls. FVC, FEV(1) and PEF were also significantly reduced in male and female children and young adults with SCD compared to their control counterparts. For both male and female patients and controls, FVC, FEV(1) and PEF correlated positively with FFM (P < 0.001). PEF for the female subjects with SCD diverged progressively with increasing age relative to the controls and the rate of change was significantly lower (P < 0.001). We conclude that pulmonary function is reduced in Nigerian children and young adults with SCD compared to controls and that for both groups, pulmonary function is directly related to body composition. These findings underscore the need for early nutritional intervention for children with SCD. SN - 1465-3664 UR - https://www.unboundmedicine.com/medline/citation/17901067/Pulmonary_function_correlates_with_body_composition_in_Nigerian_children_and_young_adults_with_sickle_cell_disease_ L2 - https://academic.oup.com/tropej/article-lookup/doi/10.1093/tropej/fmm070 DB - PRIME DP - Unbound Medicine ER -