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The relation between dietary intake of individual fatty acids, FEV1 and respiratory disease in Dutch adults.
Thorax. 2008 Mar; 63(3):208-14.T

Abstract

BACKGROUND

A reduced dietary intake of n-3 fatty acids, in association with increased n-6 fatty acid intake, has been proposed as a potential aetiological factor for chronic obstructive pulmonary disease (COPD) and asthma. However, the relative importance of individual fatty acids within the n-3 and n-6 categories on this effect has not been widely investigated. We have studied the relation between individual fatty acid intakes, lung function and self-reported respiratory symptoms and diagnoses in a representative sample of more than 13,000 Dutch adults.

METHODS

Intake of individual fatty acids was estimated by a food frequency questionnaire and analysed in relation to measures of forced expiratory volume in 1 s (FEV1) and to questionnaire reported wheeze, asthma and COPD symptoms.

RESULTS

After adjusting for confounding, we found no protective association between individual n-3 fatty acid intakes and FEV1. Higher intakes of some n-6 fatty acids were associated with lower FEV1, this effect being most marked for c22:4 n-6 docosatetraenoic acid (reduction in FEV1 between the highest and lowest quintile of intake 54.5 ml (95% CI -81.6 to -27.4)). Most of the n-6 fatty acid effects interacted significantly with smoking, their effects being strongest in current smokers. Individual n-3 fatty acid intakes were generally associated with a higher risk of wheeze in the past year, but otherwise there was little or no association between fatty acid intake and wheeze, doctor diagnosed asthma or other respiratory symptoms.

CONCLUSIONS

A high intake of n-3 fatty acids does not appear to protect against COPD or asthma, but a high intake of several n-6 fatty acids is associated with a significant reduction in FEV1, particularly in smokers. These findings indicate that high dietary intake of n-6 fatty acids, rather than reduced n-3 intake, may have an adverse effect on lung health.

Authors+Show Affiliations

University of Nottingham, Clinical Science Building, City Hospital, Nottingham NG5 1PB, UK. tricia.mckeever@nottingham.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17901161

Citation

McKeever, T M., et al. "The Relation Between Dietary Intake of Individual Fatty Acids, FEV1 and Respiratory Disease in Dutch Adults." Thorax, vol. 63, no. 3, 2008, pp. 208-14.
McKeever TM, Lewis SA, Cassano PA, et al. The relation between dietary intake of individual fatty acids, FEV1 and respiratory disease in Dutch adults. Thorax. 2008;63(3):208-14.
McKeever, T. M., Lewis, S. A., Cassano, P. A., Ocké, M., Burney, P., Britton, J., & Smit, H. A. (2008). The relation between dietary intake of individual fatty acids, FEV1 and respiratory disease in Dutch adults. Thorax, 63(3), 208-14.
McKeever TM, et al. The Relation Between Dietary Intake of Individual Fatty Acids, FEV1 and Respiratory Disease in Dutch Adults. Thorax. 2008;63(3):208-14. PubMed PMID: 17901161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relation between dietary intake of individual fatty acids, FEV1 and respiratory disease in Dutch adults. AU - McKeever,T M, AU - Lewis,S A, AU - Cassano,P A, AU - Ocké,M, AU - Burney,P, AU - Britton,J, AU - Smit,H A, Y1 - 2007/09/27/ PY - 2007/9/29/pubmed PY - 2008/4/1/medline PY - 2007/9/29/entrez SP - 208 EP - 14 JF - Thorax JO - Thorax VL - 63 IS - 3 N2 - BACKGROUND: A reduced dietary intake of n-3 fatty acids, in association with increased n-6 fatty acid intake, has been proposed as a potential aetiological factor for chronic obstructive pulmonary disease (COPD) and asthma. However, the relative importance of individual fatty acids within the n-3 and n-6 categories on this effect has not been widely investigated. We have studied the relation between individual fatty acid intakes, lung function and self-reported respiratory symptoms and diagnoses in a representative sample of more than 13,000 Dutch adults. METHODS: Intake of individual fatty acids was estimated by a food frequency questionnaire and analysed in relation to measures of forced expiratory volume in 1 s (FEV1) and to questionnaire reported wheeze, asthma and COPD symptoms. RESULTS: After adjusting for confounding, we found no protective association between individual n-3 fatty acid intakes and FEV1. Higher intakes of some n-6 fatty acids were associated with lower FEV1, this effect being most marked for c22:4 n-6 docosatetraenoic acid (reduction in FEV1 between the highest and lowest quintile of intake 54.5 ml (95% CI -81.6 to -27.4)). Most of the n-6 fatty acid effects interacted significantly with smoking, their effects being strongest in current smokers. Individual n-3 fatty acid intakes were generally associated with a higher risk of wheeze in the past year, but otherwise there was little or no association between fatty acid intake and wheeze, doctor diagnosed asthma or other respiratory symptoms. CONCLUSIONS: A high intake of n-3 fatty acids does not appear to protect against COPD or asthma, but a high intake of several n-6 fatty acids is associated with a significant reduction in FEV1, particularly in smokers. These findings indicate that high dietary intake of n-6 fatty acids, rather than reduced n-3 intake, may have an adverse effect on lung health. SN - 1468-3296 UR - https://www.unboundmedicine.com/medline/citation/17901161/The_relation_between_dietary_intake_of_individual_fatty_acids_FEV1_and_respiratory_disease_in_Dutch_adults_ L2 - http://thorax.bmj.com/cgi/pmidlookup?view=long&pmid=17901161 DB - PRIME DP - Unbound Medicine ER -