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Melatonin and its role in oxidative stress related diseases of oral cavity.
J Physiol Pharmacol. 2007 Aug; 58 Suppl 3:5-19.JP

Abstract

The role of the oral cavity in the pathogenesis of diseases of various systems such as the gastro-intestinal tract (GIT), cardiovascular and immune systems has been recently evaluated. While initially the oral cavity was considered to be mainly a source of various bacteria, their toxins and antigens, recent studies showed that it may also be a location of oxidative stress and periodontal inflammation. Accordingly, this review focuses on the involvement of melatonin (MT) in oxidative stress diseases of oral cavity as well as on potential therapeutic implications of MT in dental disorders, especially in periodontal inflammation. MT is generated and released by pineal gland and by entero-endocrine (EE) cells located in the GIT. The pattern of MT secretion from the pineal gland is controlled by an endogenous circadian timing system that conveys information about the light/dark cycle to various organs of the body, thereby organizing its seasonal and circadian rhythms. The secretion of MT from the EE cells of GIT is related mainly to feeding periods. MT is a non-toxic highly lipophilic indole, and this feature facilitates its penetration through cell membranes and its compartments. However, the most important effect of MT seems to result from its potent antioxidant, immuno-modulatory, protective and anti-cancer properties. It stimulates synthesis of type I collagen fibers and promotes bone formation. Thus, MT could be used therapeutically for instance, locally, in the oral cavity damage of mechanical, bacterial, fungal or viral origin, in post-surgical wounds caused by tooth extractions and other oral surgeries and, in helping bone formation in various auto-immunological disorders such as Sjorgen syndrome, in periodontal diseases, and in oral cancers.

Authors+Show Affiliations

Institute of Dentistry and Department of Physiology, Jagiellonian University Medical College, Cracow, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17901579

Citation

Czesnikiewicz-Guzik, M, et al. "Melatonin and Its Role in Oxidative Stress Related Diseases of Oral Cavity." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 58 Suppl 3, 2007, pp. 5-19.
Czesnikiewicz-Guzik M, Konturek SJ, Loster B, et al. Melatonin and its role in oxidative stress related diseases of oral cavity. J Physiol Pharmacol. 2007;58 Suppl 3:5-19.
Czesnikiewicz-Guzik, M., Konturek, S. J., Loster, B., Wisniewska, G., & Majewski, S. (2007). Melatonin and its role in oxidative stress related diseases of oral cavity. Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 58 Suppl 3, 5-19.
Czesnikiewicz-Guzik M, et al. Melatonin and Its Role in Oxidative Stress Related Diseases of Oral Cavity. J Physiol Pharmacol. 2007;58 Suppl 3:5-19. PubMed PMID: 17901579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melatonin and its role in oxidative stress related diseases of oral cavity. AU - Czesnikiewicz-Guzik,M, AU - Konturek,S J, AU - Loster,B, AU - Wisniewska,G, AU - Majewski,S, PY - 2007/06/16/received PY - 2007/07/02/accepted PY - 2007/12/6/pubmed PY - 2008/4/23/medline PY - 2007/12/6/entrez SP - 5 EP - 19 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J Physiol Pharmacol VL - 58 Suppl 3 N2 - The role of the oral cavity in the pathogenesis of diseases of various systems such as the gastro-intestinal tract (GIT), cardiovascular and immune systems has been recently evaluated. While initially the oral cavity was considered to be mainly a source of various bacteria, their toxins and antigens, recent studies showed that it may also be a location of oxidative stress and periodontal inflammation. Accordingly, this review focuses on the involvement of melatonin (MT) in oxidative stress diseases of oral cavity as well as on potential therapeutic implications of MT in dental disorders, especially in periodontal inflammation. MT is generated and released by pineal gland and by entero-endocrine (EE) cells located in the GIT. The pattern of MT secretion from the pineal gland is controlled by an endogenous circadian timing system that conveys information about the light/dark cycle to various organs of the body, thereby organizing its seasonal and circadian rhythms. The secretion of MT from the EE cells of GIT is related mainly to feeding periods. MT is a non-toxic highly lipophilic indole, and this feature facilitates its penetration through cell membranes and its compartments. However, the most important effect of MT seems to result from its potent antioxidant, immuno-modulatory, protective and anti-cancer properties. It stimulates synthesis of type I collagen fibers and promotes bone formation. Thus, MT could be used therapeutically for instance, locally, in the oral cavity damage of mechanical, bacterial, fungal or viral origin, in post-surgical wounds caused by tooth extractions and other oral surgeries and, in helping bone formation in various auto-immunological disorders such as Sjorgen syndrome, in periodontal diseases, and in oral cancers. SN - 0867-5910 UR - https://www.unboundmedicine.com/medline/citation/17901579/Melatonin_and_its_role_in_oxidative_stress_related_diseases_of_oral_cavity_ L2 - http://www.jpp.krakow.pl/journal/archive/08_07/pdf/5_08_07_article.pdf DB - PRIME DP - Unbound Medicine ER -