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Helicobacter pylori, anemia, and iron deficiency: relationships explored among Alaska native children.
Pediatr Infect Dis J. 2007 Oct; 26(10):927-34.PI

Abstract

BACKGROUND

Attempts to understand determinants of anemia and iron deficiency have led researchers to examine the role of Helicobacter pylori infection. The current study assessed determinants of anemia and iron deficiency, including H. pylori, in Alaska Native children.

METHODS

In 1999, a population-based survey was conducted among 86 children (67% response rate), mean age of 43.7 months (standard deviation = 16.8 months). Samples of breath, stool, and venous blood were obtained from children for measures of anemia, iron deficiency, H. pylori, fecal blood loss, and current inflammation. Standardized interviews with parents provided information on demographics, illness, and intake of dietary iron, iron-absorption inhibitors, and enhancers.

RESULTS

Of the 86 children studied, 17.4% were anemic and 38.6% were iron deficient. Forty-one percent of the cohort had H. pylori-specific IgG antibodies, 86% tested positive by the urea breath test (UBT), and 80% tested positive by the stool antigen test. Presence of H. pylori antibodies emerged as a significant risk factor for anemia and iron deficiency in adjusted analyses controlling for demographic factors, current inflammation, and antibiotic use. In contrast, children with positive UBT or stool antigen results were significantly less likely to have anemia or iron deficiency than those with negative results.

CONCLUSIONS

Results from different measures of H. pylori may reflect different stages of infection. Relationships between H. pylori and anemia/iron deficiency may depend on the phase of infection measured, with serologic tests reflecting established H. pylori infection associated with anemia/iron deficiency, and UBT and stool antigen results reflecting an earlier stage of infection.

Authors+Show Affiliations

Hubert Department of Global Health, Emory University, Atlanta, GA 30322, USA. adigiro@sph.emory.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17901799

Citation

DiGirolamo, Ann M., et al. "Helicobacter Pylori, Anemia, and Iron Deficiency: Relationships Explored Among Alaska Native Children." The Pediatric Infectious Disease Journal, vol. 26, no. 10, 2007, pp. 927-34.
DiGirolamo AM, Perry GS, Gold BD, et al. Helicobacter pylori, anemia, and iron deficiency: relationships explored among Alaska native children. Pediatr Infect Dis J. 2007;26(10):927-34.
DiGirolamo, A. M., Perry, G. S., Gold, B. D., Parkinson, A., Provost, E. M., Parvanta, I., & Grummer-Strawn, L. M. (2007). Helicobacter pylori, anemia, and iron deficiency: relationships explored among Alaska native children. The Pediatric Infectious Disease Journal, 26(10), 927-34.
DiGirolamo AM, et al. Helicobacter Pylori, Anemia, and Iron Deficiency: Relationships Explored Among Alaska Native Children. Pediatr Infect Dis J. 2007;26(10):927-34. PubMed PMID: 17901799.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori, anemia, and iron deficiency: relationships explored among Alaska native children. AU - DiGirolamo,Ann M, AU - Perry,Geraldine S, AU - Gold,Benjamin D, AU - Parkinson,Alan, AU - Provost,Ellen M, AU - Parvanta,Ibrahim, AU - Grummer-Strawn,Laurence M, PY - 2007/9/29/pubmed PY - 2007/12/6/medline PY - 2007/9/29/entrez SP - 927 EP - 34 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 26 IS - 10 N2 - BACKGROUND: Attempts to understand determinants of anemia and iron deficiency have led researchers to examine the role of Helicobacter pylori infection. The current study assessed determinants of anemia and iron deficiency, including H. pylori, in Alaska Native children. METHODS: In 1999, a population-based survey was conducted among 86 children (67% response rate), mean age of 43.7 months (standard deviation = 16.8 months). Samples of breath, stool, and venous blood were obtained from children for measures of anemia, iron deficiency, H. pylori, fecal blood loss, and current inflammation. Standardized interviews with parents provided information on demographics, illness, and intake of dietary iron, iron-absorption inhibitors, and enhancers. RESULTS: Of the 86 children studied, 17.4% were anemic and 38.6% were iron deficient. Forty-one percent of the cohort had H. pylori-specific IgG antibodies, 86% tested positive by the urea breath test (UBT), and 80% tested positive by the stool antigen test. Presence of H. pylori antibodies emerged as a significant risk factor for anemia and iron deficiency in adjusted analyses controlling for demographic factors, current inflammation, and antibiotic use. In contrast, children with positive UBT or stool antigen results were significantly less likely to have anemia or iron deficiency than those with negative results. CONCLUSIONS: Results from different measures of H. pylori may reflect different stages of infection. Relationships between H. pylori and anemia/iron deficiency may depend on the phase of infection measured, with serologic tests reflecting established H. pylori infection associated with anemia/iron deficiency, and UBT and stool antigen results reflecting an earlier stage of infection. SN - 0891-3668 UR - https://www.unboundmedicine.com/medline/citation/17901799/Helicobacter_pylori_anemia_and_iron_deficiency:_relationships_explored_among_Alaska_native_children_ L2 - https://doi.org/10.1097/INF.0b013e31812e52cd DB - PRIME DP - Unbound Medicine ER -