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The -675 4G/5G polymorphism at the Plasminogen Activator Inhibitor 1 (PAI-1) gene modulates plasma Plasminogen Activator Inhibitor 1 concentrations in response to dietary fat consumption.
Br J Nutr. 2008 Apr; 99(4):699-702.BJ

Abstract

The objective of the study was to determine whether Plasminogen Activator Inhibitor Type 1 (PAI-1) -675 4G/5G polymorphism is associated with the response of functional plasma PAI-1 concentrations to changes in the amount and quality of dietary fat in healthy subjects. PAI-1 is the major inhibitor of fibrinolysis, and a lower level of fibrinolytic activity could be implicated in an increased risk of IHD. Fifty-nine healthy Spanish volunteers (ten 4G/4G homozygotes, twenty-eight heterozygotes 4G/5G and twenty-one 5G/5G homozygotes) consumed three diets for periods of 4 weeks each: a SFA-rich diet (38 % fat, 20 % SFA), followed by a carbohydrate-rich diet (30 % fat, 55 % carbohydrate) and a MUFA-rich diet (38 % fat, 22 % MUFA) according to a randomized crossover design. At the end of each dietary period plasma lipid and functional plasma PAI-1 concentrations were determined. Subjects carrying the 4G allele (4G/4G and 4G/5G) showed a significant decrease in PAI-1 concentrations after the MUFA diet, compared with the SFA-rich and carbohydrate-rich diets (genotype x diet interaction: P = 0.028). 5G/5G homozygotes had the lowest plasma PAI-1 concentrations compared with 4G/4G and 4G/5G subjects (genotype: P = 0.002), without any changes as a result of the amount and the quality of the dietary fat. In summary, no differences in plasma PAI-1 concentration response were found after changes in dietary fat intake in 5G/5G homozygotes, although these subjects displayed the lowest concentrations of PAI-1. On the other hand, carriers of the 4G allele are more likely to hyper-respond to the presence of MUFA in the diet because of a greater decrease in PAI-1 concentrations.

Authors+Show Affiliations

Lipids and Atherosclerosis Research Unit, Hospital Universitario Reina Sofia, CIBER, Fisiopatologia, Obesidad y Nutricion, Avda. Menendez Pidal, s/n. 14004 Cordoba, Spain. pablopermar@yahoo.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17903340

Citation

Pérez-Martínez, P, et al. "The -675 4G/5G Polymorphism at the Plasminogen Activator Inhibitor 1 (PAI-1) Gene Modulates Plasma Plasminogen Activator Inhibitor 1 Concentrations in Response to Dietary Fat Consumption." The British Journal of Nutrition, vol. 99, no. 4, 2008, pp. 699-702.
Pérez-Martínez P, Adarraga-Cansino MD, Fernández de la Puebla RA, et al. The -675 4G/5G polymorphism at the Plasminogen Activator Inhibitor 1 (PAI-1) gene modulates plasma Plasminogen Activator Inhibitor 1 concentrations in response to dietary fat consumption. Br J Nutr. 2008;99(4):699-702.
Pérez-Martínez, P., Adarraga-Cansino, M. D., Fernández de la Puebla, R. A., Blanco-Molina, A., Delgado-Lista, J., Marín, C., Ordovás, J. M., López-Miranda, J., & Pérez-Jiménez, F. (2008). The -675 4G/5G polymorphism at the Plasminogen Activator Inhibitor 1 (PAI-1) gene modulates plasma Plasminogen Activator Inhibitor 1 concentrations in response to dietary fat consumption. The British Journal of Nutrition, 99(4), 699-702.
Pérez-Martínez P, et al. The -675 4G/5G Polymorphism at the Plasminogen Activator Inhibitor 1 (PAI-1) Gene Modulates Plasma Plasminogen Activator Inhibitor 1 Concentrations in Response to Dietary Fat Consumption. Br J Nutr. 2008;99(4):699-702. PubMed PMID: 17903340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The -675 4G/5G polymorphism at the Plasminogen Activator Inhibitor 1 (PAI-1) gene modulates plasma Plasminogen Activator Inhibitor 1 concentrations in response to dietary fat consumption. AU - Pérez-Martínez,P, AU - Adarraga-Cansino,M D, AU - Fernández de la Puebla,R A, AU - Blanco-Molina,A, AU - Delgado-Lista,J, AU - Marín,C, AU - Ordovás,J M, AU - López-Miranda,J, AU - Pérez-Jiménez,F, Y1 - 2007/10/01/ PY - 2007/10/2/pubmed PY - 2008/5/7/medline PY - 2007/10/2/entrez SP - 699 EP - 702 JF - The British journal of nutrition JO - Br J Nutr VL - 99 IS - 4 N2 - The objective of the study was to determine whether Plasminogen Activator Inhibitor Type 1 (PAI-1) -675 4G/5G polymorphism is associated with the response of functional plasma PAI-1 concentrations to changes in the amount and quality of dietary fat in healthy subjects. PAI-1 is the major inhibitor of fibrinolysis, and a lower level of fibrinolytic activity could be implicated in an increased risk of IHD. Fifty-nine healthy Spanish volunteers (ten 4G/4G homozygotes, twenty-eight heterozygotes 4G/5G and twenty-one 5G/5G homozygotes) consumed three diets for periods of 4 weeks each: a SFA-rich diet (38 % fat, 20 % SFA), followed by a carbohydrate-rich diet (30 % fat, 55 % carbohydrate) and a MUFA-rich diet (38 % fat, 22 % MUFA) according to a randomized crossover design. At the end of each dietary period plasma lipid and functional plasma PAI-1 concentrations were determined. Subjects carrying the 4G allele (4G/4G and 4G/5G) showed a significant decrease in PAI-1 concentrations after the MUFA diet, compared with the SFA-rich and carbohydrate-rich diets (genotype x diet interaction: P = 0.028). 5G/5G homozygotes had the lowest plasma PAI-1 concentrations compared with 4G/4G and 4G/5G subjects (genotype: P = 0.002), without any changes as a result of the amount and the quality of the dietary fat. In summary, no differences in plasma PAI-1 concentration response were found after changes in dietary fat intake in 5G/5G homozygotes, although these subjects displayed the lowest concentrations of PAI-1. On the other hand, carriers of the 4G allele are more likely to hyper-respond to the presence of MUFA in the diet because of a greater decrease in PAI-1 concentrations. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/17903340/The__675_4G/5G_polymorphism_at_the_Plasminogen_Activator_Inhibitor_1__PAI_1__gene_modulates_plasma_Plasminogen_Activator_Inhibitor_1_concentrations_in_response_to_dietary_fat_consumption_ L2 - https://www.cambridge.org/core/product/identifier/S0007114507831710/type/journal_article DB - PRIME DP - Unbound Medicine ER -