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Which tinnitus patients benefit from transcranial magnetic stimulation?
Otolaryngol Head Neck Surg. 2007 Oct; 137(4):589-95.OH

Abstract

OBJECTIVES

Chronic tinnitus is associated with hyperactivity of the central auditory system. Low-frequency repetitive transcranial magnetic stimulation (rTMS) of the temporal cortex has been proposed as a treatment for chronic tinnitus. This study determined the factors that predict a beneficial outcome with rTMS treatment.

STUDY DESIGN

Forty-five patients with chronic tinnitus underwent 10 sessions of low-frequency rTMS to their left auditory cortex. The treatment outcome was assessed with a tinnitus questionnaire. Therapeutic success was related to the patients' clinical characteristics.

RESULTS

A significant reduction in tinnitus complaints occurred after rTMS. In the questionnaire, 40% of the patients improved by five points or more. Treatment responders were characterized by shorter duration of tinnitus complaints and no hearing impairment.

CONCLUSION

Tinnitus-related neuroplastic changes might be less pronounced in patients with normal hearing and a short history of complaints. This could explain why those patients benefitted more from rTMS treatment.

Links

Publisher Full Text
journals.sagepub.com
linkinghub.elsevier.com
Aggregator Full Text

Authors+Show Affiliations

Kleinjung T
Department of Otorhinolaryngology, University of Regensburg, Germany. tobias.kleinjung@klinik.uni-regensburg.de
Steffens T
No affiliation info available
Sand P
No affiliation info available
Murthum T
No affiliation info available
Hajak G
No affiliation info available
Strutz J
No affiliation info available
Langguth B
No affiliation info available
Eichhammer P
No affiliation info available

MeSH

AdultAgedAudiometry, Pure-ToneAuditory CortexAuditory ThresholdChronic DiseaseFemaleFollow-Up StudiesHearingHumansMaleMiddle AgedPrognosisTime FactorsTinnitusTranscranial Magnetic StimulationTreatment Outcome

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17903575

Clinical Trial Links

Repetitive Transcranial Magnetic Stimulation for Chronic Subjective Tinnitus

Citation

Kleinjung, Tobias, et al. "Which Tinnitus Patients Benefit From Transcranial Magnetic Stimulation?" Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 137, no. 4, 2007, pp. 589-95.
Kleinjung T, Steffens T, Sand P, et al. Which tinnitus patients benefit from transcranial magnetic stimulation? Otolaryngol Head Neck Surg. 2007;137(4):589-95.
Kleinjung, T., Steffens, T., Sand, P., Murthum, T., Hajak, G., Strutz, J., Langguth, B., & Eichhammer, P. (2007). Which tinnitus patients benefit from transcranial magnetic stimulation? Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 137(4), 589-95.
Kleinjung T, et al. Which Tinnitus Patients Benefit From Transcranial Magnetic Stimulation. Otolaryngol Head Neck Surg. 2007;137(4):589-95. PubMed PMID: 17903575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Which tinnitus patients benefit from transcranial magnetic stimulation? AU - Kleinjung,Tobias, AU - Steffens,Thomas, AU - Sand,Philipp, AU - Murthum,Tobias, AU - Hajak,Goeran, AU - Strutz,Juergen, AU - Langguth,Berthold, AU - Eichhammer,Peter, PY - 2006/08/26/received PY - 2006/12/06/accepted PY - 2007/10/2/pubmed PY - 2007/12/7/medline PY - 2007/10/2/entrez SP - 589 EP - 95 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 137 IS - 4 N2 - OBJECTIVES: Chronic tinnitus is associated with hyperactivity of the central auditory system. Low-frequency repetitive transcranial magnetic stimulation (rTMS) of the temporal cortex has been proposed as a treatment for chronic tinnitus. This study determined the factors that predict a beneficial outcome with rTMS treatment. STUDY DESIGN: Forty-five patients with chronic tinnitus underwent 10 sessions of low-frequency rTMS to their left auditory cortex. The treatment outcome was assessed with a tinnitus questionnaire. Therapeutic success was related to the patients' clinical characteristics. RESULTS: A significant reduction in tinnitus complaints occurred after rTMS. In the questionnaire, 40% of the patients improved by five points or more. Treatment responders were characterized by shorter duration of tinnitus complaints and no hearing impairment. CONCLUSION: Tinnitus-related neuroplastic changes might be less pronounced in patients with normal hearing and a short history of complaints. This could explain why those patients benefitted more from rTMS treatment. SN - 0194-5998 UR - https://www.unboundmedicine.com/medline/citation/17903575/Which_tinnitus_patients_benefit_from_transcranial_magnetic_stimulation L2 - https://journals.sagepub.com/doi/10.1016/j.otohns.2006.12.007?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -