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Changes in depression, anxiety, anger, and personality after resective surgery for drug-resistant temporal lobe epilepsy: a 2-year follow-up study.
Epilepsy Res. 2007 Oct; 77(1):22-30.ER

Abstract

OBJECTIVE

To further elucidate the psychiatric outcome of surgical treatment for temporal lobe epilepsy (TLE).

METHODS

Fifty-two consecutive patients with drug-resistant TLE and IQ > or = 70 completed the Minnesota Multiphasic Personality Inventory, Beck Depression Inventory, Spielberger State-Trait Anxiety Inventory, and Spielberger State-Trait Anger Expression Inventory before epilepsy surgery, after 1 year, and after 2 years. Some patients also completed the 31-item Quality of Life in Epilepsy (N=29) and WHOQOL-100 (N=24) questionnaires. During the follow-up period, patients were maintained on a stable medication regimen. Multivariate repeated measures analysis of variance was used to examine changes in psychiatric variables over time.

RESULTS

Seizure outcome was excellent (89% in Engel class I after 2 years). There were only a few significant changes over time in the MMPI profile, suggesting a decrease in interpersonal sensitivity, irritability, and social introversion. Anxiety decreased significantly with a gradual decline, anger dropped significantly after remaining basically flat during the first year, while depression showed a gradual but non-significant decline. Younger age and shorter duration of epilepsy were associated with greater improvement in several anger dimensions. In the patient subgroup with quality of life data available, greater improvement in overall quality of life and key life domains (income, work capacity, personal relationships) was found to be associated with greater decrease in depression, anxiety, and anger.

CONCLUSION

The relatively slow decrease of emotional distress over time and its correlation with changes in some key life domains suggest that patients may experience difficulties in switching from a 'sick' role to a 'normal' role, and may easily be disappointed if expectations of positive life changes are not rapidly met. Some counselling sessions early after surgery may be useful to address these issues. The findings also suggest that surgery may yield greater emotional benefits if performed early.

Authors+Show Affiliations

Epilepsy Surgery Unit, Department of Neurological Sciences, IRCCS Neuromed, Pozzilli (IS), Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17904823

Citation

Meldolesi, G N., et al. "Changes in Depression, Anxiety, Anger, and Personality After Resective Surgery for Drug-resistant Temporal Lobe Epilepsy: a 2-year Follow-up Study." Epilepsy Research, vol. 77, no. 1, 2007, pp. 22-30.
Meldolesi GN, Di Gennaro G, Quarato PP, et al. Changes in depression, anxiety, anger, and personality after resective surgery for drug-resistant temporal lobe epilepsy: a 2-year follow-up study. Epilepsy Res. 2007;77(1):22-30.
Meldolesi, G. N., Di Gennaro, G., Quarato, P. P., Esposito, V., Grammaldo, L. G., Morosini, P., Cascavilla, I., & Picardi, A. (2007). Changes in depression, anxiety, anger, and personality after resective surgery for drug-resistant temporal lobe epilepsy: a 2-year follow-up study. Epilepsy Research, 77(1), 22-30.
Meldolesi GN, et al. Changes in Depression, Anxiety, Anger, and Personality After Resective Surgery for Drug-resistant Temporal Lobe Epilepsy: a 2-year Follow-up Study. Epilepsy Res. 2007;77(1):22-30. PubMed PMID: 17904823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in depression, anxiety, anger, and personality after resective surgery for drug-resistant temporal lobe epilepsy: a 2-year follow-up study. AU - Meldolesi,G N, AU - Di Gennaro,G, AU - Quarato,P P, AU - Esposito,V, AU - Grammaldo,L G, AU - Morosini,P, AU - Cascavilla,I, AU - Picardi,A, Y1 - 2007/09/29/ PY - 2007/05/15/received PY - 2007/07/27/revised PY - 2007/08/13/accepted PY - 2007/10/2/pubmed PY - 2008/1/3/medline PY - 2007/10/2/entrez SP - 22 EP - 30 JF - Epilepsy research JO - Epilepsy Res VL - 77 IS - 1 N2 - OBJECTIVE: To further elucidate the psychiatric outcome of surgical treatment for temporal lobe epilepsy (TLE). METHODS: Fifty-two consecutive patients with drug-resistant TLE and IQ > or = 70 completed the Minnesota Multiphasic Personality Inventory, Beck Depression Inventory, Spielberger State-Trait Anxiety Inventory, and Spielberger State-Trait Anger Expression Inventory before epilepsy surgery, after 1 year, and after 2 years. Some patients also completed the 31-item Quality of Life in Epilepsy (N=29) and WHOQOL-100 (N=24) questionnaires. During the follow-up period, patients were maintained on a stable medication regimen. Multivariate repeated measures analysis of variance was used to examine changes in psychiatric variables over time. RESULTS: Seizure outcome was excellent (89% in Engel class I after 2 years). There were only a few significant changes over time in the MMPI profile, suggesting a decrease in interpersonal sensitivity, irritability, and social introversion. Anxiety decreased significantly with a gradual decline, anger dropped significantly after remaining basically flat during the first year, while depression showed a gradual but non-significant decline. Younger age and shorter duration of epilepsy were associated with greater improvement in several anger dimensions. In the patient subgroup with quality of life data available, greater improvement in overall quality of life and key life domains (income, work capacity, personal relationships) was found to be associated with greater decrease in depression, anxiety, and anger. CONCLUSION: The relatively slow decrease of emotional distress over time and its correlation with changes in some key life domains suggest that patients may experience difficulties in switching from a 'sick' role to a 'normal' role, and may easily be disappointed if expectations of positive life changes are not rapidly met. Some counselling sessions early after surgery may be useful to address these issues. The findings also suggest that surgery may yield greater emotional benefits if performed early. SN - 0920-1211 UR - https://www.unboundmedicine.com/medline/citation/17904823/Changes_in_depression_anxiety_anger_and_personality_after_resective_surgery_for_drug_resistant_temporal_lobe_epilepsy:_a_2_year_follow_up_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-1211(07)00246-X DB - PRIME DP - Unbound Medicine ER -