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Gonadal hormone modulation of the behavioral effects of Delta9-tetrahydrocannabinol in male and female rats.
Eur J Pharmacol 2008; 578(1):37-42EJ

Abstract

Female rats are more sensitive than males to many behavioral effects of cannabinoids. The purpose of the present study was to determine if sex differences in the antinociceptive and motoric effects of Delta(9)-tetrahydrocannabinol (THC) are due to activational effects of gonadal steroid hormones. THC-induced antinociception (tail withdrawal, paw pressure tests) and motoric effects (horizontal locomotion, catalepsy) were compared in male and female gonadectomized rats that were chronically treated with hormone (testosterone in males, estradiol in females) vs. those that were gonadectomized and had no hormone replacement. THC's effects were also compared between gonadally intact females tested during vaginal estrus vs. diestrus. THC (5 and 10 mg/kg i.p.) produced very similar antinociceptive effects in no-hormone vs. testosterone-treated males, but significantly less locomotor suppression in testosterone-treated males than those with no hormone replacement. In gonadectomized females, estradiol enhanced THC's antinociceptive but not motoric effects. In gonadally intact, cycling females, 5 mg/kg THC produced slightly to significantly greater behavioral effects in estrous than in diestrous females. These results suggest that sex differences in THC-induced behavioral effects in the adult rat can be attributed to activational effects of testosterone in males and/or estradiol in females.

Authors+Show Affiliations

Department of Psychology, Washington State University, Pullman, WA 99164-4820, USA. craft@wsu.eduNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17905227

Citation

Craft, Rebecca M., and Michael D. Leitl. "Gonadal Hormone Modulation of the Behavioral Effects of Delta9-tetrahydrocannabinol in Male and Female Rats." European Journal of Pharmacology, vol. 578, no. 1, 2008, pp. 37-42.
Craft RM, Leitl MD. Gonadal hormone modulation of the behavioral effects of Delta9-tetrahydrocannabinol in male and female rats. Eur J Pharmacol. 2008;578(1):37-42.
Craft, R. M., & Leitl, M. D. (2008). Gonadal hormone modulation of the behavioral effects of Delta9-tetrahydrocannabinol in male and female rats. European Journal of Pharmacology, 578(1), pp. 37-42.
Craft RM, Leitl MD. Gonadal Hormone Modulation of the Behavioral Effects of Delta9-tetrahydrocannabinol in Male and Female Rats. Eur J Pharmacol. 2008 Jan 6;578(1):37-42. PubMed PMID: 17905227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gonadal hormone modulation of the behavioral effects of Delta9-tetrahydrocannabinol in male and female rats. AU - Craft,Rebecca M, AU - Leitl,Michael D, Y1 - 2007/09/19/ PY - 2007/06/20/received PY - 2007/08/23/revised PY - 2007/09/10/accepted PY - 2007/10/2/pubmed PY - 2008/5/7/medline PY - 2007/10/2/entrez SP - 37 EP - 42 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 578 IS - 1 N2 - Female rats are more sensitive than males to many behavioral effects of cannabinoids. The purpose of the present study was to determine if sex differences in the antinociceptive and motoric effects of Delta(9)-tetrahydrocannabinol (THC) are due to activational effects of gonadal steroid hormones. THC-induced antinociception (tail withdrawal, paw pressure tests) and motoric effects (horizontal locomotion, catalepsy) were compared in male and female gonadectomized rats that were chronically treated with hormone (testosterone in males, estradiol in females) vs. those that were gonadectomized and had no hormone replacement. THC's effects were also compared between gonadally intact females tested during vaginal estrus vs. diestrus. THC (5 and 10 mg/kg i.p.) produced very similar antinociceptive effects in no-hormone vs. testosterone-treated males, but significantly less locomotor suppression in testosterone-treated males than those with no hormone replacement. In gonadectomized females, estradiol enhanced THC's antinociceptive but not motoric effects. In gonadally intact, cycling females, 5 mg/kg THC produced slightly to significantly greater behavioral effects in estrous than in diestrous females. These results suggest that sex differences in THC-induced behavioral effects in the adult rat can be attributed to activational effects of testosterone in males and/or estradiol in females. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/17905227/Gonadal_hormone_modulation_of_the_behavioral_effects_of_Delta9_tetrahydrocannabinol_in_male_and_female_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(07)00993-4 DB - PRIME DP - Unbound Medicine ER -