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Multiple experimental approaches of immunotoxic effects of mercury chloride in the blue mussel, Mytilus edulis, through in vivo, in tubo and in vitro exposures.
Environ Pollut. 2008 May; 153(2):416-23.EP

Abstract

Biological impairments due to mercury discharge into the environment are now an issue of global concern. From the three forms of mercury found in aquatic ecosystems, the immunotoxic effects of mercury chloride were examined in the model animal, the blue mussel. In order to investigate the toxic potency of this chemical, three exposure regimes were carried out: chronic exposure of groups of individuals, a new protocol "in tubo" designed for sub-acute exposures of individuals, and acute exposures of target cells. Chronic exposure revealed significant immunotoxic effects after 7 days at 10(-6)M, while acute exposures showed significant inhibition of phagocytosis at 10(-4)M and 10(-3)M. In sub-acute exposures both circulating haemocytes and haemocyte mortality increased at 10(-4)M and 10(-3)M while phagocytosis and the clearance rate drew hormetic toxic effects on healthy individuals. These results suggest the use of the "in tubo" design for bivalve toxicological individual studies.

Authors+Show Affiliations

Laboratoire des sciences de l'environnement marin, UMR CNRS 6539, Institut Universitaire Européen de la Mer, Université de Bretagne Occidentale, Place Nicolas Copernic, 29 280 Plouzane, France. matthieu.duchemin@univ-brest.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17905492

Citation

Duchemin, Matthieu B., et al. "Multiple Experimental Approaches of Immunotoxic Effects of Mercury Chloride in the Blue Mussel, Mytilus Edulis, Through in Vivo, in Tubo and in Vitro Exposures." Environmental Pollution (Barking, Essex : 1987), vol. 153, no. 2, 2008, pp. 416-23.
Duchemin MB, Auffret M, Wessel N, et al. Multiple experimental approaches of immunotoxic effects of mercury chloride in the blue mussel, Mytilus edulis, through in vivo, in tubo and in vitro exposures. Environ Pollut. 2008;153(2):416-23.
Duchemin, M. B., Auffret, M., Wessel, N., Fortier, M., Morin, Y., Pellerin, J., & Fournier, M. (2008). Multiple experimental approaches of immunotoxic effects of mercury chloride in the blue mussel, Mytilus edulis, through in vivo, in tubo and in vitro exposures. Environmental Pollution (Barking, Essex : 1987), 153(2), 416-23.
Duchemin MB, et al. Multiple Experimental Approaches of Immunotoxic Effects of Mercury Chloride in the Blue Mussel, Mytilus Edulis, Through in Vivo, in Tubo and in Vitro Exposures. Environ Pollut. 2008;153(2):416-23. PubMed PMID: 17905492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple experimental approaches of immunotoxic effects of mercury chloride in the blue mussel, Mytilus edulis, through in vivo, in tubo and in vitro exposures. AU - Duchemin,Matthieu B, AU - Auffret,Michel, AU - Wessel,Nathalie, AU - Fortier,Marlène, AU - Morin,Yves, AU - Pellerin,Jocelyne, AU - Fournier,Michel, Y1 - 2007/10/01/ PY - 2007/01/17/received PY - 2007/08/05/revised PY - 2007/08/08/accepted PY - 2007/10/2/pubmed PY - 2008/12/17/medline PY - 2007/10/2/entrez SP - 416 EP - 23 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ Pollut VL - 153 IS - 2 N2 - Biological impairments due to mercury discharge into the environment are now an issue of global concern. From the three forms of mercury found in aquatic ecosystems, the immunotoxic effects of mercury chloride were examined in the model animal, the blue mussel. In order to investigate the toxic potency of this chemical, three exposure regimes were carried out: chronic exposure of groups of individuals, a new protocol "in tubo" designed for sub-acute exposures of individuals, and acute exposures of target cells. Chronic exposure revealed significant immunotoxic effects after 7 days at 10(-6)M, while acute exposures showed significant inhibition of phagocytosis at 10(-4)M and 10(-3)M. In sub-acute exposures both circulating haemocytes and haemocyte mortality increased at 10(-4)M and 10(-3)M while phagocytosis and the clearance rate drew hormetic toxic effects on healthy individuals. These results suggest the use of the "in tubo" design for bivalve toxicological individual studies. SN - 0269-7491 UR - https://www.unboundmedicine.com/medline/citation/17905492/Multiple_experimental_approaches_of_immunotoxic_effects_of_mercury_chloride_in_the_blue_mussel_Mytilus_edulis_through_in_vivo_in_tubo_and_in_vitro_exposures_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0269-7491(07)00434-4 DB - PRIME DP - Unbound Medicine ER -