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Montelukast inhibits inflammatory responses in small airways of the Guinea-pig.
Pulm Pharmacol Ther. 2008; 21(2):317-23.PP

Abstract

Increased resistance in the small airways is a major contributor of airway obstruction in asthma. The role of leukotrienes (LT) in determining inflammation and obstruction of small size bronchi is not completely understood. Here, we have examined the effect of the cysteinyl-leukotriene (CysLT 1) receptor antagonist, montelukast, against the bronchoconstriction and inflammatory responses induced by exogenous leukotriene and by allergen challenge in small size (<or=1mm) Guinea-pig bronchi. Montelukast potently (pA(2) 8.3) inhibited the contraction induced by LTD4 in small bronchi taken from naïve Guinea-pigs. Furthermore, montelukast reduced the contraction produced by in vitro ovalbumin (OVA) challenge in small size bronchi from sensitized Guinea-pigs. Montelukast (10 microg kg(-1)) also blocked plasma protein extravasation and accumulation of inflammatory cells (eosinophils) induced by OVA challenge in small intra-parenchymal bronchi of OVA sensitized animals. These findings provide additional evidence that CysLT 1 receptor antagonism reduces allergic reactions that cause contractile and inflammatory responses in Guinea-pig small airways during OVA challenge. If the anti-bronchospastic and anti-inflammatory actions of the CysLT 1 receptor antagonists observed in the small airways of Guinea-pigs occur also in man these effects may contribute to the beneficial effects of montelukast in asthmatic patients.

Authors+Show Affiliations

Department of Critical Care Medicine and Surgery, Unit of Geriatric Medicine, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17905619

Citation

Harrison, Selena, et al. "Montelukast Inhibits Inflammatory Responses in Small Airways of the Guinea-pig." Pulmonary Pharmacology & Therapeutics, vol. 21, no. 2, 2008, pp. 317-23.
Harrison S, Gatti R, Baraldo S, et al. Montelukast inhibits inflammatory responses in small airways of the Guinea-pig. Pulm Pharmacol Ther. 2008;21(2):317-23.
Harrison, S., Gatti, R., Baraldo, S., Oliani, K. L., Andre, E., Trevisani, M., Gazzieri, D., Saetta, M., & Geppetti, P. (2008). Montelukast inhibits inflammatory responses in small airways of the Guinea-pig. Pulmonary Pharmacology & Therapeutics, 21(2), 317-23.
Harrison S, et al. Montelukast Inhibits Inflammatory Responses in Small Airways of the Guinea-pig. Pulm Pharmacol Ther. 2008;21(2):317-23. PubMed PMID: 17905619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Montelukast inhibits inflammatory responses in small airways of the Guinea-pig. AU - Harrison,Selena, AU - Gatti,Raffaele, AU - Baraldo,Simonetta, AU - Oliani,Kim Lokar, AU - Andre,Eunice, AU - Trevisani,Marcello, AU - Gazzieri,David, AU - Saetta,Marina, AU - Geppetti,Pierangelo, Y1 - 2007/08/29/ PY - 2007/03/07/received PY - 2007/06/17/revised PY - 2007/07/16/accepted PY - 2007/10/2/pubmed PY - 2008/8/2/medline PY - 2007/10/2/entrez SP - 317 EP - 23 JF - Pulmonary pharmacology & therapeutics JO - Pulm Pharmacol Ther VL - 21 IS - 2 N2 - Increased resistance in the small airways is a major contributor of airway obstruction in asthma. The role of leukotrienes (LT) in determining inflammation and obstruction of small size bronchi is not completely understood. Here, we have examined the effect of the cysteinyl-leukotriene (CysLT 1) receptor antagonist, montelukast, against the bronchoconstriction and inflammatory responses induced by exogenous leukotriene and by allergen challenge in small size (<or=1mm) Guinea-pig bronchi. Montelukast potently (pA(2) 8.3) inhibited the contraction induced by LTD4 in small bronchi taken from naïve Guinea-pigs. Furthermore, montelukast reduced the contraction produced by in vitro ovalbumin (OVA) challenge in small size bronchi from sensitized Guinea-pigs. Montelukast (10 microg kg(-1)) also blocked plasma protein extravasation and accumulation of inflammatory cells (eosinophils) induced by OVA challenge in small intra-parenchymal bronchi of OVA sensitized animals. These findings provide additional evidence that CysLT 1 receptor antagonism reduces allergic reactions that cause contractile and inflammatory responses in Guinea-pig small airways during OVA challenge. If the anti-bronchospastic and anti-inflammatory actions of the CysLT 1 receptor antagonists observed in the small airways of Guinea-pigs occur also in man these effects may contribute to the beneficial effects of montelukast in asthmatic patients. SN - 1094-5539 UR - https://www.unboundmedicine.com/medline/citation/17905619/Montelukast_inhibits_inflammatory_responses_in_small_airways_of_the_Guinea_pig_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1094-5539(07)00071-5 DB - PRIME DP - Unbound Medicine ER -