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Nasal congestion after visual sexual stimulation with and without sildenafil (Viagra): a randomized placebo-controlled study.
Eur Arch Otorhinolaryngol. 2008 Mar; 265(3):303-6.EA

Abstract

Sildenafil (Viagra) is a selective phosphodiesterase type 5 inhibitor (PDE5-I) approved for treatment of erectile dysfunction. Although relatively well-tolerated, sildenafil is associated with undesired effects including headache, flushing, dyspepsia, nasal congestion, and visual disturbances. In the present study we explored the impact of sildenafil on nasal airway parameters in young potent men. Eleven men (age 26.0 +/- 1.8 years) with normal BMI (25.7 +/- 0.5) and without nasal respiratory disorders were enrolled in a double-blind, crossover study. All men underwent evaluation of systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), SpO2%, acoustic rhinometry, and nasal endoscopy before and after placebo or sildenafil (50 mg) plus visual sexual stimulation (VSS). Nasal examination was performed using 0 degrees rigid telescopes, 4 mm in diameter. A Student's t test was used for direct comparisons, while the Kruskal-Wallis test (K-W) was utilized for multiple comparisons. After administration of sildenafil plus VSS, the minimum cross sectional area (MCA) was significantly lower that observed with either placebo (P = 0.03) or sildenafil alone (P = 0.003). However, the post-stimulation values did not demonstrate any significant differences among the different treatment arms (P = 0.48; DF = 2; K-W test). In contrast, endonasal volume (VOL) was significantly lower after sildenafil + VSS (P = 0.01), but not after placebo + VSS (P = 0.18). None of the other parameters monitored showed any significant variations. Rhinoscopy showed a characteristic increase of the volume of the inferior turbinates, with subjective differences between placebo and sildenafil. These preliminary results suggest that sildenafil reduces nasal volume, and that sexual stimulation may decrease nasal airflow by itself.

Authors+Show Affiliations

Department of Otorhinolaryngology, IRRCS San Raffaele Hospital, Vita-Salute University, via Olgettina 60, 20132 Milan, Italy. trimarchi.matteo@hsr.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17906871

Citation

Trimarchi, Matteo, et al. "Nasal Congestion After Visual Sexual Stimulation With and Without Sildenafil (Viagra): a Randomized Placebo-controlled Study." European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, vol. 265, no. 3, 2008, pp. 303-6.
Trimarchi M, Salonia A, Bondi S, et al. Nasal congestion after visual sexual stimulation with and without sildenafil (Viagra): a randomized placebo-controlled study. Eur Arch Otorhinolaryngol. 2008;265(3):303-6.
Trimarchi, M., Salonia, A., Bondi, S., Montorsi, F., & Bussi, M. (2008). Nasal congestion after visual sexual stimulation with and without sildenafil (Viagra): a randomized placebo-controlled study. European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 265(3), 303-6.
Trimarchi M, et al. Nasal Congestion After Visual Sexual Stimulation With and Without Sildenafil (Viagra): a Randomized Placebo-controlled Study. Eur Arch Otorhinolaryngol. 2008;265(3):303-6. PubMed PMID: 17906871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nasal congestion after visual sexual stimulation with and without sildenafil (Viagra): a randomized placebo-controlled study. AU - Trimarchi,Matteo, AU - Salonia,Andrea, AU - Bondi,Stefano, AU - Montorsi,Francesco, AU - Bussi,Mario, Y1 - 2007/09/29/ PY - 2007/06/20/received PY - 2007/08/30/accepted PY - 2007/10/2/pubmed PY - 2008/8/6/medline PY - 2007/10/2/entrez SP - 303 EP - 6 JF - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery JO - Eur Arch Otorhinolaryngol VL - 265 IS - 3 N2 - Sildenafil (Viagra) is a selective phosphodiesterase type 5 inhibitor (PDE5-I) approved for treatment of erectile dysfunction. Although relatively well-tolerated, sildenafil is associated with undesired effects including headache, flushing, dyspepsia, nasal congestion, and visual disturbances. In the present study we explored the impact of sildenafil on nasal airway parameters in young potent men. Eleven men (age 26.0 +/- 1.8 years) with normal BMI (25.7 +/- 0.5) and without nasal respiratory disorders were enrolled in a double-blind, crossover study. All men underwent evaluation of systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), SpO2%, acoustic rhinometry, and nasal endoscopy before and after placebo or sildenafil (50 mg) plus visual sexual stimulation (VSS). Nasal examination was performed using 0 degrees rigid telescopes, 4 mm in diameter. A Student's t test was used for direct comparisons, while the Kruskal-Wallis test (K-W) was utilized for multiple comparisons. After administration of sildenafil plus VSS, the minimum cross sectional area (MCA) was significantly lower that observed with either placebo (P = 0.03) or sildenafil alone (P = 0.003). However, the post-stimulation values did not demonstrate any significant differences among the different treatment arms (P = 0.48; DF = 2; K-W test). In contrast, endonasal volume (VOL) was significantly lower after sildenafil + VSS (P = 0.01), but not after placebo + VSS (P = 0.18). None of the other parameters monitored showed any significant variations. Rhinoscopy showed a characteristic increase of the volume of the inferior turbinates, with subjective differences between placebo and sildenafil. These preliminary results suggest that sildenafil reduces nasal volume, and that sexual stimulation may decrease nasal airflow by itself. SN - 0937-4477 UR - https://www.unboundmedicine.com/medline/citation/17906871/Nasal_congestion_after_visual_sexual_stimulation_with_and_without_sildenafil__Viagra_:_a_randomized_placebo_controlled_study_ L2 - https://dx.doi.org/10.1007/s00405-007-0452-4 DB - PRIME DP - Unbound Medicine ER -