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Body mass index, alcohol, tobacco and symptomatic gallstone disease: a Swedish twin study.
J Intern Med. 2007 Nov; 262(5):581-7.JI

Abstract

BACKGROUND/AIMS

Both genetic and environmental factors are involved in the pathogenesis of gallstone disease (GD). We aimed to examine the association between symptomatic GD and overweight (body mass index, BMI, 25-30 kg m(-2)), obesity (BMI > 30 kg m(-2)), alcohol, smoking and smoke-free tobacco by analysing a large twin population.

METHODS

The Swedish Twin Registry (STR) was linked to the Swedish Hospital Discharge and Causes of Death Registries for GD and GD-surgery related diagnoses. Weight, height, use of alcohol, smoking and smoke-free tobacco were provided by STR and analysed for possible associations by conditional logistic regression.

RESULTS

Overweight and obesity were associated with a significantly higher risk for symptomatic GD in the whole study population (OR 1.86 and OR 3.38; CI: 1.52-2.28 and 2.28-5.02 respectively). High alcohol consumption was associated with a lower risk for GD in the whole population (OR 0.62; CI: 0.51-0.74) with no difference between discordant monozygotic and dizygotic twins (OR 1.08 and OR 0.96; CI: 0.82-1.42 and 0.79-1.16). Smoking or smoke-free tobacco was not correlated with GD.

CONCLUSION

Consistent with epidemiological studies, we found positive associations between BMI and the development of symptomatic GD. High alcohol consumption was associated with a decreased risk against GD. Tobacco use has no impact on GD.

Authors+Show Affiliations

Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden. despina.katsika@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

17908165

Citation

Katsika, D, et al. "Body Mass Index, Alcohol, Tobacco and Symptomatic Gallstone Disease: a Swedish Twin Study." Journal of Internal Medicine, vol. 262, no. 5, 2007, pp. 581-7.
Katsika D, Tuvblad C, Einarsson C, et al. Body mass index, alcohol, tobacco and symptomatic gallstone disease: a Swedish twin study. J Intern Med. 2007;262(5):581-7.
Katsika, D., Tuvblad, C., Einarsson, C., Lichtenstein, P., & Marschall, H. U. (2007). Body mass index, alcohol, tobacco and symptomatic gallstone disease: a Swedish twin study. Journal of Internal Medicine, 262(5), 581-7.
Katsika D, et al. Body Mass Index, Alcohol, Tobacco and Symptomatic Gallstone Disease: a Swedish Twin Study. J Intern Med. 2007;262(5):581-7. PubMed PMID: 17908165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body mass index, alcohol, tobacco and symptomatic gallstone disease: a Swedish twin study. AU - Katsika,D, AU - Tuvblad,C, AU - Einarsson,C, AU - Lichtenstein,P, AU - Marschall,H-U, Y1 - 2007/10/01/ PY - 2007/10/3/pubmed PY - 2007/12/6/medline PY - 2007/10/3/entrez SP - 581 EP - 7 JF - Journal of internal medicine JO - J Intern Med VL - 262 IS - 5 N2 - BACKGROUND/AIMS: Both genetic and environmental factors are involved in the pathogenesis of gallstone disease (GD). We aimed to examine the association between symptomatic GD and overweight (body mass index, BMI, 25-30 kg m(-2)), obesity (BMI > 30 kg m(-2)), alcohol, smoking and smoke-free tobacco by analysing a large twin population. METHODS: The Swedish Twin Registry (STR) was linked to the Swedish Hospital Discharge and Causes of Death Registries for GD and GD-surgery related diagnoses. Weight, height, use of alcohol, smoking and smoke-free tobacco were provided by STR and analysed for possible associations by conditional logistic regression. RESULTS: Overweight and obesity were associated with a significantly higher risk for symptomatic GD in the whole study population (OR 1.86 and OR 3.38; CI: 1.52-2.28 and 2.28-5.02 respectively). High alcohol consumption was associated with a lower risk for GD in the whole population (OR 0.62; CI: 0.51-0.74) with no difference between discordant monozygotic and dizygotic twins (OR 1.08 and OR 0.96; CI: 0.82-1.42 and 0.79-1.16). Smoking or smoke-free tobacco was not correlated with GD. CONCLUSION: Consistent with epidemiological studies, we found positive associations between BMI and the development of symptomatic GD. High alcohol consumption was associated with a decreased risk against GD. Tobacco use has no impact on GD. SN - 0954-6820 UR - https://www.unboundmedicine.com/medline/citation/17908165/Body_mass_index_alcohol_tobacco_and_symptomatic_gallstone_disease:_a_Swedish_twin_study_ L2 - https://doi.org/10.1111/j.1365-2796.2007.01860.x DB - PRIME DP - Unbound Medicine ER -