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Family history of asthma and atopy: in-depth analyses of the impact on asthma and wheeze in 7- to 8-year-old children.
Pediatrics. 2007 Oct; 120(4):741-8.Ped

Abstract

OBJECTIVES

Development of asthma in children is influenced by interactions between genetic and environmental factors. It is unclear whether paternal or maternal histories of disease confer different risks. Previous population-based studies have not stratified analyses by child gender and sensitization status. Our aim was to study in detail the hereditary component of childhood asthma.

METHODS

A population-based cohort of 3430 (97% of invited) 7- to 8-year-old school children participated in an expanded International Study of Asthma and Allergy in Childhood survey, and two thirds were skin-prick tested. Heredity was defined as a family history of (1) asthma and (2) atopy (allergic rhinitis or eczema). Multivariate analyses corrected for known risk factors for asthma.

RESULTS

At ages 7 to 8, prevalence of asthma was 5.3% among the children and 9.0% among the parents. In children without parental asthma or parental atopy, the prevalence of asthma was 2.8%. Corrected for parental asthma, parental atopy was a weak but significant risk factor. There were minor differences in the impact of parental disease between sensitized and nonsensitized children and between boys and girls.

CONCLUSIONS

As risk factors for childhood asthma, there were major differences between parental asthma and parental atopy. Sibling asthma was only a marker of parental disease. Interactions between parental disease and the child's allergic sensitization or gender were not statistically significant. Asthma in both parents conferred a multiplicative risk, whereas the effect of parental atopy was additive, however limited. Asthma and atopy, despite their causal relationship, are separate entities and could be inherited differently. This large, population-based, and well-characterized cohort study does not confirm parent-of-origin effects found in previous studies.

Authors+Show Affiliations

Obstructive Lung Disease in Northern Sweden Studies, Department of Medicine, Sunderby Central Hospital of Norrbotten, Luleå, Sweden. anders.bjerg@lung.umu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17908760

Citation

Bjerg, Anders, et al. "Family History of Asthma and Atopy: In-depth Analyses of the Impact On Asthma and Wheeze in 7- to 8-year-old Children." Pediatrics, vol. 120, no. 4, 2007, pp. 741-8.
Bjerg A, Hedman L, Perzanowski MS, et al. Family history of asthma and atopy: in-depth analyses of the impact on asthma and wheeze in 7- to 8-year-old children. Pediatrics. 2007;120(4):741-8.
Bjerg, A., Hedman, L., Perzanowski, M. S., Platts-Mills, T., Lundbäck, B., & Rönmark, E. (2007). Family history of asthma and atopy: in-depth analyses of the impact on asthma and wheeze in 7- to 8-year-old children. Pediatrics, 120(4), 741-8.
Bjerg A, et al. Family History of Asthma and Atopy: In-depth Analyses of the Impact On Asthma and Wheeze in 7- to 8-year-old Children. Pediatrics. 2007;120(4):741-8. PubMed PMID: 17908760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Family history of asthma and atopy: in-depth analyses of the impact on asthma and wheeze in 7- to 8-year-old children. AU - Bjerg,Anders, AU - Hedman,Linnea, AU - Perzanowski,Matthew S, AU - Platts-Mills,Thomas, AU - Lundbäck,Bo, AU - Rönmark,Eva, PY - 2007/10/3/pubmed PY - 2007/10/30/medline PY - 2007/10/3/entrez SP - 741 EP - 8 JF - Pediatrics JO - Pediatrics VL - 120 IS - 4 N2 - OBJECTIVES: Development of asthma in children is influenced by interactions between genetic and environmental factors. It is unclear whether paternal or maternal histories of disease confer different risks. Previous population-based studies have not stratified analyses by child gender and sensitization status. Our aim was to study in detail the hereditary component of childhood asthma. METHODS: A population-based cohort of 3430 (97% of invited) 7- to 8-year-old school children participated in an expanded International Study of Asthma and Allergy in Childhood survey, and two thirds were skin-prick tested. Heredity was defined as a family history of (1) asthma and (2) atopy (allergic rhinitis or eczema). Multivariate analyses corrected for known risk factors for asthma. RESULTS: At ages 7 to 8, prevalence of asthma was 5.3% among the children and 9.0% among the parents. In children without parental asthma or parental atopy, the prevalence of asthma was 2.8%. Corrected for parental asthma, parental atopy was a weak but significant risk factor. There were minor differences in the impact of parental disease between sensitized and nonsensitized children and between boys and girls. CONCLUSIONS: As risk factors for childhood asthma, there were major differences between parental asthma and parental atopy. Sibling asthma was only a marker of parental disease. Interactions between parental disease and the child's allergic sensitization or gender were not statistically significant. Asthma in both parents conferred a multiplicative risk, whereas the effect of parental atopy was additive, however limited. Asthma and atopy, despite their causal relationship, are separate entities and could be inherited differently. This large, population-based, and well-characterized cohort study does not confirm parent-of-origin effects found in previous studies. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/17908760/Family_history_of_asthma_and_atopy:_in_depth_analyses_of_the_impact_on_asthma_and_wheeze_in_7__to_8_year_old_children_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=17908760 DB - PRIME DP - Unbound Medicine ER -