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The effect of the NMDA receptor antagonist MK-801 on the acquisition and extinction of learned fear in the developing rat.
Learn Mem. 2007 Oct; 14(10):665-8.LM

Abstract

Recent findings reveal qualitative developmental differences in extinction of learned fear. The present study explored potential developmental differences in the role of NMDA in acquisition and extinction. Rats were injected with MK-801 prior to fear conditioning or extinction training. Acquisition was found to be NMDA dependent in both age groups, whereas extinction was found to be NMDA dependent in 23-day-old rats, but NMDA independent in 16-day-old rats. These results illustrate another fundamental developmental difference in extinction as well as a dissociation in the role of NMDA in the acquisition and extinction of fear early in development.

Authors+Show Affiliations

Langton JM
School of Psychology, The University of New South Wales, Sydney 2052, Australia. jlangton@psy.unsw.edu.au
Kim JH
No affiliation info available
Nicholas J
No affiliation info available
Richardson R
No affiliation info available

MeSH

Age FactorsAnimalsAvoidance LearningConditioning, ClassicalDizocilpine MaleateExcitatory Amino Acid AntagonistsExtinction, PsychologicalFearFreezing Reaction, CatalepticRatsReceptors, N-Methyl-D-AspartateValine

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17909101

Citation

Langton, Julia M., et al. "The Effect of the NMDA Receptor Antagonist MK-801 On the Acquisition and Extinction of Learned Fear in the Developing Rat." Learning & Memory (Cold Spring Harbor, N.Y.), vol. 14, no. 10, 2007, pp. 665-8.
Langton JM, Kim JH, Nicholas J, et al. The effect of the NMDA receptor antagonist MK-801 on the acquisition and extinction of learned fear in the developing rat. Learn Mem. 2007;14(10):665-8.
Langton, J. M., Kim, J. H., Nicholas, J., & Richardson, R. (2007). The effect of the NMDA receptor antagonist MK-801 on the acquisition and extinction of learned fear in the developing rat. Learning & Memory (Cold Spring Harbor, N.Y.), 14(10), 665-8.
Langton JM, et al. The Effect of the NMDA Receptor Antagonist MK-801 On the Acquisition and Extinction of Learned Fear in the Developing Rat. Learn Mem. 2007;14(10):665-8. PubMed PMID: 17909101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of the NMDA receptor antagonist MK-801 on the acquisition and extinction of learned fear in the developing rat. AU - Langton,Julia M, AU - Kim,Jee Hyun, AU - Nicholas,Jennifer, AU - Richardson,Rick, Y1 - 2007/09/25/ PY - 2007/10/3/pubmed PY - 2007/10/31/medline PY - 2007/10/3/entrez SP - 665 EP - 8 JF - Learning & memory (Cold Spring Harbor, N.Y.) JO - Learn Mem VL - 14 IS - 10 N2 - Recent findings reveal qualitative developmental differences in extinction of learned fear. The present study explored potential developmental differences in the role of NMDA in acquisition and extinction. Rats were injected with MK-801 prior to fear conditioning or extinction training. Acquisition was found to be NMDA dependent in both age groups, whereas extinction was found to be NMDA dependent in 23-day-old rats, but NMDA independent in 16-day-old rats. These results illustrate another fundamental developmental difference in extinction as well as a dissociation in the role of NMDA in the acquisition and extinction of fear early in development. SN - 1549-5485 UR - https://www.unboundmedicine.com/medline/citation/17909101/The_effect_of_the_NMDA_receptor_antagonist_MK_801_on_the_acquisition_and_extinction_of_learned_fear_in_the_developing_rat_ DB - PRIME DP - Unbound Medicine ER -