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Cinnamon products as a possible etiologic factor in orofacial granulomatosis.
Med Oral Patol Oral Cir Bucal 2007; 12(6):E440-4MO

Abstract

OBJECTIVES

It has been reported that clinical changes due to hypersensitivity reactions to various foods, preservatives, and oral hygiene products may be consistent with the characteristic signs of orofacial granulomatosis (OFG). The objective of this study was to examine 37 well-documented cases of cinnamon-induced contact stomatitis for clinical and histological features consistent with a diagnosis of OFG.

STUDY DESIGN

We reviewed the records of the 37 cases to screen them for the clinical and histopathologic features of OFG.

RESULTS

Twelve patients showed clinical characteristics of OFG. The most commonly affected site was the gingiva. Focal non-caseating, epitheloid granulomas were observed in four histologic specimens. Multinucleated giant cells were observed in an additional four cases.

CONCLUSIONS

Although OFG may have multiple etiologies, it is clear that, in some instances, a hypersensitivity reaction to cinnamon products can elicit lesions consistent with OFG.

Authors+Show Affiliations

Department of Periodontology, Nihon University, School of Dentistry at Matsudo, Chiba, Japan. endo.hiroyasu@nihon-u.ac.jp.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17909510

Citation

Endo, Hiroyasu, and Terry D. Rees. "Cinnamon Products as a Possible Etiologic Factor in Orofacial Granulomatosis." Medicina Oral, Patologia Oral Y Cirugia Bucal, vol. 12, no. 6, 2007, pp. E440-4.
Endo H, Rees TD. Cinnamon products as a possible etiologic factor in orofacial granulomatosis. Med Oral Patol Oral Cir Bucal. 2007;12(6):E440-4.
Endo, H., & Rees, T. D. (2007). Cinnamon products as a possible etiologic factor in orofacial granulomatosis. Medicina Oral, Patologia Oral Y Cirugia Bucal, 12(6), pp. E440-4.
Endo H, Rees TD. Cinnamon Products as a Possible Etiologic Factor in Orofacial Granulomatosis. Med Oral Patol Oral Cir Bucal. 2007 Oct 1;12(6):E440-4. PubMed PMID: 17909510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cinnamon products as a possible etiologic factor in orofacial granulomatosis. AU - Endo,Hiroyasu, AU - Rees,Terry D, Y1 - 2007/10/01/ PY - 2007/10/3/pubmed PY - 2007/11/6/medline PY - 2007/10/3/entrez SP - E440 EP - 4 JF - Medicina oral, patologia oral y cirugia bucal JO - Med Oral Patol Oral Cir Bucal VL - 12 IS - 6 N2 - OBJECTIVES: It has been reported that clinical changes due to hypersensitivity reactions to various foods, preservatives, and oral hygiene products may be consistent with the characteristic signs of orofacial granulomatosis (OFG). The objective of this study was to examine 37 well-documented cases of cinnamon-induced contact stomatitis for clinical and histological features consistent with a diagnosis of OFG. STUDY DESIGN: We reviewed the records of the 37 cases to screen them for the clinical and histopathologic features of OFG. RESULTS: Twelve patients showed clinical characteristics of OFG. The most commonly affected site was the gingiva. Focal non-caseating, epitheloid granulomas were observed in four histologic specimens. Multinucleated giant cells were observed in an additional four cases. CONCLUSIONS: Although OFG may have multiple etiologies, it is clear that, in some instances, a hypersensitivity reaction to cinnamon products can elicit lesions consistent with OFG. SN - 1698-6946 UR - https://www.unboundmedicine.com/medline/citation/17909510/Cinnamon_products_as_a_possible_etiologic_factor_in_orofacial_granulomatosis_ L2 - http://www.medicinaoral.com/pubmed/medoralv12_i6_p440.pdf DB - PRIME DP - Unbound Medicine ER -