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Development and in-vivo evaluation of insulin-loaded chitosan phthalate microspheres for oral delivery.
J Pharm Pharmacol. 2007 Oct; 59(10):1345-51.JP

Abstract

Novel chitosan phthalate microspheres containing insulin were prepared by emulsion cross-linking technique. The feasibility of these microspheres as oral insulin delivery carriers was evaluated. The pH-responsive release behaviour of insulin from microspheres was analysed. The ability of chitosan phthalate-insulin microspheres to enhance intestinal absorption and improve the relative pharmacological availability of insulin was investigated by monitoring the plasma glucose and insulin level of streptozotocin-induced diabetic rats after oral administration of microspheres at insulin dose of 20 IU kg(-1). In simulated gastric fluid (pH 2.0), insulin release from the microspheres was very slow. However, as the pH of the medium was changed to simulated intestinal fluid (pH 7.4), a rapid release of insulin occurred. The relative pharmacological efficacy for chitosan phthalate microspheres (18.66 +/- 3.84%) was almost four-fold higher than the efficacy of the chitosan phthalate-insulin solution administration (4.08 +/- 1.52%). Chitosan phthalate microspheres sustained the plasma glucose at pre-diabetic level for at least 16 h. These findings suggest that the microsphere is a promising carrier as oral insulin delivery system.

Authors+Show Affiliations

Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi, India. ubaidnkl@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17910808

Citation

Ubaidulla, Udhumansha, et al. "Development and In-vivo Evaluation of Insulin-loaded Chitosan Phthalate Microspheres for Oral Delivery." The Journal of Pharmacy and Pharmacology, vol. 59, no. 10, 2007, pp. 1345-51.
Ubaidulla U, Khar RK, Ahmed FJ, et al. Development and in-vivo evaluation of insulin-loaded chitosan phthalate microspheres for oral delivery. J Pharm Pharmacol. 2007;59(10):1345-51.
Ubaidulla, U., Khar, R. K., Ahmed, F. J., & Panda, A. K. (2007). Development and in-vivo evaluation of insulin-loaded chitosan phthalate microspheres for oral delivery. The Journal of Pharmacy and Pharmacology, 59(10), 1345-51.
Ubaidulla U, et al. Development and In-vivo Evaluation of Insulin-loaded Chitosan Phthalate Microspheres for Oral Delivery. J Pharm Pharmacol. 2007;59(10):1345-51. PubMed PMID: 17910808.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development and in-vivo evaluation of insulin-loaded chitosan phthalate microspheres for oral delivery. AU - Ubaidulla,Udhumansha, AU - Khar,Roop Kishan, AU - Ahmed,Farhan Jalees, AU - Panda,Amulya Kumar, PY - 2007/10/4/pubmed PY - 2007/12/19/medline PY - 2007/10/4/entrez SP - 1345 EP - 51 JF - The Journal of pharmacy and pharmacology JO - J Pharm Pharmacol VL - 59 IS - 10 N2 - Novel chitosan phthalate microspheres containing insulin were prepared by emulsion cross-linking technique. The feasibility of these microspheres as oral insulin delivery carriers was evaluated. The pH-responsive release behaviour of insulin from microspheres was analysed. The ability of chitosan phthalate-insulin microspheres to enhance intestinal absorption and improve the relative pharmacological availability of insulin was investigated by monitoring the plasma glucose and insulin level of streptozotocin-induced diabetic rats after oral administration of microspheres at insulin dose of 20 IU kg(-1). In simulated gastric fluid (pH 2.0), insulin release from the microspheres was very slow. However, as the pH of the medium was changed to simulated intestinal fluid (pH 7.4), a rapid release of insulin occurred. The relative pharmacological efficacy for chitosan phthalate microspheres (18.66 +/- 3.84%) was almost four-fold higher than the efficacy of the chitosan phthalate-insulin solution administration (4.08 +/- 1.52%). Chitosan phthalate microspheres sustained the plasma glucose at pre-diabetic level for at least 16 h. These findings suggest that the microsphere is a promising carrier as oral insulin delivery system. SN - 0022-3573 UR - https://www.unboundmedicine.com/medline/citation/17910808/Development_and_in_vivo_evaluation_of_insulin_loaded_chitosan_phthalate_microspheres_for_oral_delivery_ L2 - https://doi.org/10.1211/jpp.59.10.0003 DB - PRIME DP - Unbound Medicine ER -