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Soluble P-selectin during a single hemodialysis session in patients with chronic renal failure and erythropoietin treatment.
Clin Appl Thromb Hemost. 2007 Oct; 13(4):410-5.CA

Abstract

In several studies, hemodialysis (HD) patients treated with recombinant human erythropoietin (rHuEPO) because of renal anemia showed increased levels of soluble adhesion molecules. The purpose of the study was to investigate the changes of soluble P-selectin (sSELP) and its relationship to platelet activation during a single HD session in patients with long-term rHuEPO treatment. Fifty-two HD patients with chronic renal failure were involved--26 with rHuEPO treatment (EPO group) and 26 without (non-EPO group). Thirty healthy subjects served as the control group. The sSELP, beta-thromboglobulin, and platelet factor 4 plasma levels were measured before and after a single 4-hour HD session on a cuprophane dialyzer. The basal beta-thromboglobulin and platelet factor 4 plasma levels were significantly increased in both HD groups compared with healthy controls but did not change after a single HD session, except for a significant decrease of platelet factor 4 in the non-EPO group. The predialysis sSELP plasma levels did not differ significantly compared with those of the healthy controls, but there was a significant increase of sSELP levels after a single HD session in both groups (EPO, P < .005; non-EPO, P < .05, respectively). These results suppose that the increased sSELP level was released from platelets during the course of a single HD session. The more significant increase of the sSELP plasma levels in EPO group during HD indicates that platelets are more activated in patients with long-term rHuEPO treatment, and this fact could partially explain the suspected tendency for thrombosis in these patients.

Authors+Show Affiliations

National Centre of Haemostasis and Thrombosis, Comenius University, Martin, Slovakia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17911193

Citation

Stasko, Ján, et al. "Soluble P-selectin During a Single Hemodialysis Session in Patients With Chronic Renal Failure and Erythropoietin Treatment." Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, vol. 13, no. 4, 2007, pp. 410-5.
Stasko J, Galajda P, Ivanková J, et al. Soluble P-selectin during a single hemodialysis session in patients with chronic renal failure and erythropoietin treatment. Clin Appl Thromb Hemost. 2007;13(4):410-5.
Stasko, J., Galajda, P., Ivanková, J., Hollý, P., Rozborilová, E., & Kubisz, P. (2007). Soluble P-selectin during a single hemodialysis session in patients with chronic renal failure and erythropoietin treatment. Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 13(4), 410-5.
Stasko J, et al. Soluble P-selectin During a Single Hemodialysis Session in Patients With Chronic Renal Failure and Erythropoietin Treatment. Clin Appl Thromb Hemost. 2007;13(4):410-5. PubMed PMID: 17911193.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soluble P-selectin during a single hemodialysis session in patients with chronic renal failure and erythropoietin treatment. AU - Stasko,Ján, AU - Galajda,Peter, AU - Ivanková,Jela, AU - Hollý,Pavol, AU - Rozborilová,Eva, AU - Kubisz,Peter, PY - 2007/10/4/pubmed PY - 2007/11/8/medline PY - 2007/10/4/entrez SP - 410 EP - 5 JF - Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis JO - Clin. Appl. Thromb. Hemost. VL - 13 IS - 4 N2 - In several studies, hemodialysis (HD) patients treated with recombinant human erythropoietin (rHuEPO) because of renal anemia showed increased levels of soluble adhesion molecules. The purpose of the study was to investigate the changes of soluble P-selectin (sSELP) and its relationship to platelet activation during a single HD session in patients with long-term rHuEPO treatment. Fifty-two HD patients with chronic renal failure were involved--26 with rHuEPO treatment (EPO group) and 26 without (non-EPO group). Thirty healthy subjects served as the control group. The sSELP, beta-thromboglobulin, and platelet factor 4 plasma levels were measured before and after a single 4-hour HD session on a cuprophane dialyzer. The basal beta-thromboglobulin and platelet factor 4 plasma levels were significantly increased in both HD groups compared with healthy controls but did not change after a single HD session, except for a significant decrease of platelet factor 4 in the non-EPO group. The predialysis sSELP plasma levels did not differ significantly compared with those of the healthy controls, but there was a significant increase of sSELP levels after a single HD session in both groups (EPO, P < .005; non-EPO, P < .05, respectively). These results suppose that the increased sSELP level was released from platelets during the course of a single HD session. The more significant increase of the sSELP plasma levels in EPO group during HD indicates that platelets are more activated in patients with long-term rHuEPO treatment, and this fact could partially explain the suspected tendency for thrombosis in these patients. SN - 1076-0296 UR - https://www.unboundmedicine.com/medline/citation/17911193/Soluble_P_selectin_during_a_single_hemodialysis_session_in_patients_with_chronic_renal_failure_and_erythropoietin_treatment_ L2 - http://journals.sagepub.com/doi/full/10.1177/1076029607303348?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -