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Efficacy of intravenous immunoglobulin in multifocal motor neuropathy.
Ann N Y Acad Sci. 2007 Sep; 1110:248-55.AN

Abstract

Multifocal motor neuropathy is a distinct entity, whose treatment differs from that of other chronic immune-mediated neuropathies, mainly chronic inflammatory demyelinating polyradiculoneuropathy, and its variant, multifocal acquired demyelinating sensory and motor neuropathy, although they share some electrophysiological characteristics. From the first descriptions, intravenous immunoglobulins (IVIg) have been considered to be the gold standard of treatment for multifocal motor neuropathy. However, if the effectiveness of IVIg has been confirmed by several randomized, double-blind, placebo-controlled trials, only a few patients experience persistent improvement after a single or few courses of therapy, and the long-term efficacy of IVIg in this disease is currently debated. Consequently, there is a need for new therapeutic strategies that focus on the effects and the costs of this therapy over long-term follow-up.

Authors+Show Affiliations

Reference Center for Neuromuscular Diseases, Bâtiment Babinski, Hôpital de la Salpêtrière, 47 boulevard de l'Hôpital, 75651 Paris cedex 13, France. jean-marc.leger@psl.aphp.frNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17911439

Citation

Leger, Jean-Marc, et al. "Efficacy of Intravenous Immunoglobulin in Multifocal Motor Neuropathy." Annals of the New York Academy of Sciences, vol. 1110, 2007, pp. 248-55.
Leger JM, Vargas S, Lievens I. Efficacy of intravenous immunoglobulin in multifocal motor neuropathy. Ann N Y Acad Sci. 2007;1110:248-55.
Leger, J. M., Vargas, S., & Lievens, I. (2007). Efficacy of intravenous immunoglobulin in multifocal motor neuropathy. Annals of the New York Academy of Sciences, 1110, 248-55.
Leger JM, Vargas S, Lievens I. Efficacy of Intravenous Immunoglobulin in Multifocal Motor Neuropathy. Ann N Y Acad Sci. 2007;1110:248-55. PubMed PMID: 17911439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of intravenous immunoglobulin in multifocal motor neuropathy. AU - Leger,Jean-Marc, AU - Vargas,Steven, AU - Lievens,Isabelle, PY - 2007/10/4/pubmed PY - 2007/12/13/medline PY - 2007/10/4/entrez SP - 248 EP - 55 JF - Annals of the New York Academy of Sciences JO - Ann. N. Y. Acad. Sci. VL - 1110 N2 - Multifocal motor neuropathy is a distinct entity, whose treatment differs from that of other chronic immune-mediated neuropathies, mainly chronic inflammatory demyelinating polyradiculoneuropathy, and its variant, multifocal acquired demyelinating sensory and motor neuropathy, although they share some electrophysiological characteristics. From the first descriptions, intravenous immunoglobulins (IVIg) have been considered to be the gold standard of treatment for multifocal motor neuropathy. However, if the effectiveness of IVIg has been confirmed by several randomized, double-blind, placebo-controlled trials, only a few patients experience persistent improvement after a single or few courses of therapy, and the long-term efficacy of IVIg in this disease is currently debated. Consequently, there is a need for new therapeutic strategies that focus on the effects and the costs of this therapy over long-term follow-up. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/17911439/Efficacy_of_intravenous_immunoglobulin_in_multifocal_motor_neuropathy_ L2 - https://doi.org/10.1196/annals.1423.026 DB - PRIME DP - Unbound Medicine ER -