Tags

Type your tag names separated by a space and hit enter

Pulse corticosteroid therapy for alopecia areata: study of 139 patients.
Dermatology. 2007; 215(4):320-4.D

Abstract

BACKGROUND/AIM

Recent reports of pulse corticosteroid therapy for alopecia areata (AA) show its efficacy for patients with a history of < or = 1 year but not for recalcitrant cases or alopecia totalis/universalis. The purpose of this study was to evaluate the efficacy and safety of pulse corticosteroid therapy for recent-onset AA patients.

METHOD

A total of 139 severe AA patients aged >15 years were included in this study. The duration from the onset of active hair loss was within 12 months for 125 (89.9%) of those patients.

RESULTS

Of the patients, 72.7% had hair loss on > 50% of their scalp area. Among the recent-onset group (duration of AA < or = 6 months), 59.4% were good responders (> 75% regrowth of alopecia lesions), while 15.8% with > 6 months duration showed a good response. Recent-onset AA patients with less severe disease (< or = 50% hair loss) responded at a rate of 88.0%, but only 21.4% of recent-onset patients with 100% hair loss responded. No serious adverse effects were observed.

Authors+Show Affiliations

Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17911990

Citation

Nakajima, Takeshi, et al. "Pulse Corticosteroid Therapy for Alopecia Areata: Study of 139 Patients." Dermatology (Basel, Switzerland), vol. 215, no. 4, 2007, pp. 320-4.
Nakajima T, Inui S, Itami S. Pulse corticosteroid therapy for alopecia areata: study of 139 patients. Dermatology. 2007;215(4):320-4.
Nakajima, T., Inui, S., & Itami, S. (2007). Pulse corticosteroid therapy for alopecia areata: study of 139 patients. Dermatology (Basel, Switzerland), 215(4), 320-4.
Nakajima T, Inui S, Itami S. Pulse Corticosteroid Therapy for Alopecia Areata: Study of 139 Patients. Dermatology. 2007;215(4):320-4. PubMed PMID: 17911990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pulse corticosteroid therapy for alopecia areata: study of 139 patients. AU - Nakajima,Takeshi, AU - Inui,Shigeki, AU - Itami,Satoshi, PY - 2007/01/26/received PY - 2007/05/01/accepted PY - 2007/10/4/pubmed PY - 2007/10/30/medline PY - 2007/10/4/entrez SP - 320 EP - 4 JF - Dermatology (Basel, Switzerland) JO - Dermatology VL - 215 IS - 4 N2 - BACKGROUND/AIM: Recent reports of pulse corticosteroid therapy for alopecia areata (AA) show its efficacy for patients with a history of < or = 1 year but not for recalcitrant cases or alopecia totalis/universalis. The purpose of this study was to evaluate the efficacy and safety of pulse corticosteroid therapy for recent-onset AA patients. METHOD: A total of 139 severe AA patients aged >15 years were included in this study. The duration from the onset of active hair loss was within 12 months for 125 (89.9%) of those patients. RESULTS: Of the patients, 72.7% had hair loss on > 50% of their scalp area. Among the recent-onset group (duration of AA < or = 6 months), 59.4% were good responders (> 75% regrowth of alopecia lesions), while 15.8% with > 6 months duration showed a good response. Recent-onset AA patients with less severe disease (< or = 50% hair loss) responded at a rate of 88.0%, but only 21.4% of recent-onset patients with 100% hair loss responded. No serious adverse effects were observed. SN - 1421-9832 UR - https://www.unboundmedicine.com/medline/citation/17911990/Pulse_corticosteroid_therapy_for_alopecia_areata:_study_of_139_patients_ L2 - https://www.karger.com?DOI=10.1159/000107626 DB - PRIME DP - Unbound Medicine ER -