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Effects of AM1346, a high-affinity CB1 receptor selective anandamide analog, on open-field behavior in rats.
Behav Pharmacol. 2007 Nov; 18(7):673-80.BP

Abstract

AM1346 is a cannabinoid receptor type 1 (CB1R) anandamide analog [alkoxyacid amide of N-eicosa-(5Z, 8Z, 11Z, 14Z)-tetraenylamine] with high affinity and selectivity for the CB1 vs. CB2 receptor [Ki (CB1)=1.5 nmol/l; Ki (CB2)=152 nmol/l]. The present study characterized the effects of AM1346 (5.6-18 mg/kg) and its interaction with the CB1R antagonist/inverse agonist SR141716 (1-5.6 mg/kg) on open-field behaviors of rats. AM1346 reduced ambulation (horizontal activity), rearing (vertical activity) and increased the degree of circling and the latency to leave the central area of the open-field arena. AM1346 also tended to reduce defecation and to increase vocalization in a dose-dependent manner. In pretreatment studies, SR141716 completely blocked the effects of AM1346 on circling and latency and partially antagonized the effects of 18 mg/kg AM1346 on ambulation and rearing. SR141716 also tended to decrease AM1346-induced vocalization in a dose-dependent manner. Earlier studies have shown that SR141716, given alone, can increase grooming behavior and, as well, produces dose-related increases in scratching. In the present studies, these effects were attenuated in a dose-related manner by AM1346. The present profile of behavioral effects for AM1346 is consistent with its designation as a CB1R agonist. When combined with drug discrimination data (surmountable antagonism of effects of SR141716 by Delta(9)-THC and AM1346 but not by methanandamide, i.e. AM356), these data indicate that the anandamide analog AM1346 may be more behaviorally similar to cannabinoids like Delta(9)-THC than to other anandamide-based molecules such as methanandamide.

Authors+Show Affiliations

Department of Psychology, Temple University, Philadelphia, Pennsylvania, USA. t.jarbe@neu.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17912052

Citation

Järbe, Torbjörn U C., et al. "Effects of AM1346, a High-affinity CB1 Receptor Selective Anandamide Analog, On Open-field Behavior in Rats." Behavioural Pharmacology, vol. 18, no. 7, 2007, pp. 673-80.
Järbe TU, DiPatrizio NV, Li C, et al. Effects of AM1346, a high-affinity CB1 receptor selective anandamide analog, on open-field behavior in rats. Behav Pharmacol. 2007;18(7):673-80.
Järbe, T. U., DiPatrizio, N. V., Li, C., & Makriyannis, A. (2007). Effects of AM1346, a high-affinity CB1 receptor selective anandamide analog, on open-field behavior in rats. Behavioural Pharmacology, 18(7), 673-80.
Järbe TU, et al. Effects of AM1346, a High-affinity CB1 Receptor Selective Anandamide Analog, On Open-field Behavior in Rats. Behav Pharmacol. 2007;18(7):673-80. PubMed PMID: 17912052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of AM1346, a high-affinity CB1 receptor selective anandamide analog, on open-field behavior in rats. AU - Järbe,Torbjörn U C, AU - DiPatrizio,Nicholas V, AU - Li,Chen, AU - Makriyannis,Alexandros, PY - 2007/10/4/pubmed PY - 2008/1/30/medline PY - 2007/10/4/entrez SP - 673 EP - 80 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 18 IS - 7 N2 - AM1346 is a cannabinoid receptor type 1 (CB1R) anandamide analog [alkoxyacid amide of N-eicosa-(5Z, 8Z, 11Z, 14Z)-tetraenylamine] with high affinity and selectivity for the CB1 vs. CB2 receptor [Ki (CB1)=1.5 nmol/l; Ki (CB2)=152 nmol/l]. The present study characterized the effects of AM1346 (5.6-18 mg/kg) and its interaction with the CB1R antagonist/inverse agonist SR141716 (1-5.6 mg/kg) on open-field behaviors of rats. AM1346 reduced ambulation (horizontal activity), rearing (vertical activity) and increased the degree of circling and the latency to leave the central area of the open-field arena. AM1346 also tended to reduce defecation and to increase vocalization in a dose-dependent manner. In pretreatment studies, SR141716 completely blocked the effects of AM1346 on circling and latency and partially antagonized the effects of 18 mg/kg AM1346 on ambulation and rearing. SR141716 also tended to decrease AM1346-induced vocalization in a dose-dependent manner. Earlier studies have shown that SR141716, given alone, can increase grooming behavior and, as well, produces dose-related increases in scratching. In the present studies, these effects were attenuated in a dose-related manner by AM1346. The present profile of behavioral effects for AM1346 is consistent with its designation as a CB1R agonist. When combined with drug discrimination data (surmountable antagonism of effects of SR141716 by Delta(9)-THC and AM1346 but not by methanandamide, i.e. AM356), these data indicate that the anandamide analog AM1346 may be more behaviorally similar to cannabinoids like Delta(9)-THC than to other anandamide-based molecules such as methanandamide. SN - 0955-8810 UR - https://www.unboundmedicine.com/medline/citation/17912052/Effects_of_AM1346_a_high_affinity_CB1_receptor_selective_anandamide_analog_on_open_field_behavior_in_rats_ DB - PRIME DP - Unbound Medicine ER -