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Diagnostic value of event-related evoked potentials N200 and P300 subcomponents in early diagnosis of Alzheimer's disease and mild cognitive impairment.
J Clin Neurophysiol. 2007 Oct; 24(5):405-12.JC

Abstract

Event-related potentials (ERPs) have a large application in the evaluation of cognitive processes, particularly in Alzheimer's disease (AD). The aim of the present study was to evaluate the clinical relevance of event-related evoked potentials (N2 and P3 subcomponents) in early diagnosis of AD and mild cognitive impairment (MCI). We prospectively studied 60 subjects. They all underwent the following investigations: neurologic and neuropsychological examination; functional evaluation, i.e., ERPs; cerebral imagery (morphologic and functional). Subjects were classified into 3 groups: group 1: 30 dementia of Alzheimer type (NINCDS-ADRDA, DSM-IV criteria); group 2: 20 MCI; and group 3: 10 control subjects. ERPs were significantly different between the groups (AD, MCI, control subjects), with a marked increase of P3 latencies, particularly when compared with N2 latencies (P < 0.0001). Furthermore, sensitivity was 87% to 95% for the differentiation of AD patients from MCI and control subjects, using prolonged P3 latencies (specificity, 90% to 95%), whereas using N2 prolonged latencies, sensitivity was 70% to 75% (specificity, 70% to 90%). Moreover, in the MCI group, N2 latencies strongly discriminated MCI from control subjects, with 90% sensitivity and 70% specificity and correctly categorized 80% of MCI subjects against 73% for P3. The abnormalities of N2 and P3 components may be linked, in AD and MCI, to an alteration of automatic and controlled attention processing.

Authors+Show Affiliations

Department of Neurology, University Hospital of Montpellier, France. k-bennys@chu-montpellier.frNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17912065

Citation

Bennys, Karim, et al. "Diagnostic Value of Event-related Evoked Potentials N200 and P300 Subcomponents in Early Diagnosis of Alzheimer's Disease and Mild Cognitive Impairment." Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society, vol. 24, no. 5, 2007, pp. 405-12.
Bennys K, Portet F, Touchon J, et al. Diagnostic value of event-related evoked potentials N200 and P300 subcomponents in early diagnosis of Alzheimer's disease and mild cognitive impairment. J Clin Neurophysiol. 2007;24(5):405-12.
Bennys, K., Portet, F., Touchon, J., & Rondouin, G. (2007). Diagnostic value of event-related evoked potentials N200 and P300 subcomponents in early diagnosis of Alzheimer's disease and mild cognitive impairment. Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society, 24(5), 405-12.
Bennys K, et al. Diagnostic Value of Event-related Evoked Potentials N200 and P300 Subcomponents in Early Diagnosis of Alzheimer's Disease and Mild Cognitive Impairment. J Clin Neurophysiol. 2007;24(5):405-12. PubMed PMID: 17912065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic value of event-related evoked potentials N200 and P300 subcomponents in early diagnosis of Alzheimer's disease and mild cognitive impairment. AU - Bennys,Karim, AU - Portet,Florence, AU - Touchon,Jacques, AU - Rondouin,Gérard, PY - 2007/10/4/pubmed PY - 2007/12/13/medline PY - 2007/10/4/entrez SP - 405 EP - 12 JF - Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society JO - J Clin Neurophysiol VL - 24 IS - 5 N2 - Event-related potentials (ERPs) have a large application in the evaluation of cognitive processes, particularly in Alzheimer's disease (AD). The aim of the present study was to evaluate the clinical relevance of event-related evoked potentials (N2 and P3 subcomponents) in early diagnosis of AD and mild cognitive impairment (MCI). We prospectively studied 60 subjects. They all underwent the following investigations: neurologic and neuropsychological examination; functional evaluation, i.e., ERPs; cerebral imagery (morphologic and functional). Subjects were classified into 3 groups: group 1: 30 dementia of Alzheimer type (NINCDS-ADRDA, DSM-IV criteria); group 2: 20 MCI; and group 3: 10 control subjects. ERPs were significantly different between the groups (AD, MCI, control subjects), with a marked increase of P3 latencies, particularly when compared with N2 latencies (P < 0.0001). Furthermore, sensitivity was 87% to 95% for the differentiation of AD patients from MCI and control subjects, using prolonged P3 latencies (specificity, 90% to 95%), whereas using N2 prolonged latencies, sensitivity was 70% to 75% (specificity, 70% to 90%). Moreover, in the MCI group, N2 latencies strongly discriminated MCI from control subjects, with 90% sensitivity and 70% specificity and correctly categorized 80% of MCI subjects against 73% for P3. The abnormalities of N2 and P3 components may be linked, in AD and MCI, to an alteration of automatic and controlled attention processing. SN - 0736-0258 UR - https://www.unboundmedicine.com/medline/citation/17912065/Diagnostic_value_of_event_related_evoked_potentials_N200_and_P300_subcomponents_in_early_diagnosis_of_Alzheimer's_disease_and_mild_cognitive_impairment_ L2 - https://doi.org/10.1097/WNP.0b013e31815068d5 DB - PRIME DP - Unbound Medicine ER -