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Association of body mass index with heartburn, regurgitation and esophagitis: results of the Progression of Gastroesophageal Reflux Disease study.

Abstract

BACKGROUND

Overweight and obesity are believed to be risk factors for gastroesophageal reflux disease (GERD). The aim of the present study was to analyze the impact of body mass index (BMI) on the severity and frequency of reflux symptoms and esophagitis in a large cohort of reflux patients.

METHODS

As part of the Progression of Gastroesophageal Reflux Disease (ProGERD) study, 6215 patients with clinically assessed GERD were included in the present investigation (53% male, 52 +/- 14 years; 47% female, 56 +/- 14 years). Heartburn and regurgitation symptoms were assessed using the validated Reflux Disease Questionnaire. Endoscopies were performed and patients were subsequently classified as having non-erosive or erosive disease. To examine the association between BMI, GERD symptoms, and esophagitis, odds ratios (OR) and 95% confidence intervals (95%CI) were calculated using logistic regression models.

RESULTS

In patients with GERD, higher BMI was associated with more frequent and more severe heartburn and regurgitation, as well as with esophagitis. The effects were more pronounced for regurgitation than for heartburn. The strongest association was between obesity and severity of regurgitation symptoms (women: OR 2.11, 95%CI 1.60-2.77; men: OR 2.15, 95%CI 1.59-2.90). Obese women, but not men, had an increased risk of severe esophagitis compared to women with normal weight (OR 2.51, 95%CI 1.53-4.12).

CONCLUSIONS

In patients with GERD, higher BMI was associated with more severe and more frequent reflux symptoms and esophagitis.

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  • Authors+Show Affiliations

    ,

    Institute for Social Medicine, Epidemiology, and Health Economics, Charité University Medical Center, Berlin, Germany. marc.nocon@charite.de

    , , , , , ,

    Source

    MeSH

    Adult
    Aged
    Body Mass Index
    Disease Progression
    Esophagitis
    Esophagoscopy
    Female
    Gastroesophageal Reflux
    Heartburn
    Humans
    Logistic Models
    Longitudinal Studies
    Male
    Middle Aged
    Obesity
    Odds Ratio
    Risk Assessment
    Risk Factors
    Severity of Illness Index
    Sex Factors
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17914941

    Citation

    Nocon, Marc, et al. "Association of Body Mass Index With Heartburn, Regurgitation and Esophagitis: Results of the Progression of Gastroesophageal Reflux Disease Study." Journal of Gastroenterology and Hepatology, vol. 22, no. 11, 2007, pp. 1728-31.
    Nocon M, Labenz J, Jaspersen D, et al. Association of body mass index with heartburn, regurgitation and esophagitis: results of the Progression of Gastroesophageal Reflux Disease study. J Gastroenterol Hepatol. 2007;22(11):1728-31.
    Nocon, M., Labenz, J., Jaspersen, D., Meyer-Sabellek, W., Stolte, M., Lind, T., ... Willich, S. N. (2007). Association of body mass index with heartburn, regurgitation and esophagitis: results of the Progression of Gastroesophageal Reflux Disease study. Journal of Gastroenterology and Hepatology, 22(11), pp. 1728-31.
    Nocon M, et al. Association of Body Mass Index With Heartburn, Regurgitation and Esophagitis: Results of the Progression of Gastroesophageal Reflux Disease Study. J Gastroenterol Hepatol. 2007;22(11):1728-31. PubMed PMID: 17914941.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association of body mass index with heartburn, regurgitation and esophagitis: results of the Progression of Gastroesophageal Reflux Disease study. AU - Nocon,Marc, AU - Labenz,Joachim, AU - Jaspersen,Daniel, AU - Meyer-Sabellek,Wolfgang, AU - Stolte,Manfred, AU - Lind,Tore, AU - Malfertheiner,Peter, AU - Willich,Stefan N, PY - 2007/10/5/pubmed PY - 2008/1/19/medline PY - 2007/10/5/entrez SP - 1728 EP - 31 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 22 IS - 11 N2 - BACKGROUND: Overweight and obesity are believed to be risk factors for gastroesophageal reflux disease (GERD). The aim of the present study was to analyze the impact of body mass index (BMI) on the severity and frequency of reflux symptoms and esophagitis in a large cohort of reflux patients. METHODS: As part of the Progression of Gastroesophageal Reflux Disease (ProGERD) study, 6215 patients with clinically assessed GERD were included in the present investigation (53% male, 52 +/- 14 years; 47% female, 56 +/- 14 years). Heartburn and regurgitation symptoms were assessed using the validated Reflux Disease Questionnaire. Endoscopies were performed and patients were subsequently classified as having non-erosive or erosive disease. To examine the association between BMI, GERD symptoms, and esophagitis, odds ratios (OR) and 95% confidence intervals (95%CI) were calculated using logistic regression models. RESULTS: In patients with GERD, higher BMI was associated with more frequent and more severe heartburn and regurgitation, as well as with esophagitis. The effects were more pronounced for regurgitation than for heartburn. The strongest association was between obesity and severity of regurgitation symptoms (women: OR 2.11, 95%CI 1.60-2.77; men: OR 2.15, 95%CI 1.59-2.90). Obese women, but not men, had an increased risk of severe esophagitis compared to women with normal weight (OR 2.51, 95%CI 1.53-4.12). CONCLUSIONS: In patients with GERD, higher BMI was associated with more severe and more frequent reflux symptoms and esophagitis. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/17914941/Association_of_body_mass_index_with_heartburn_regurgitation_and_esophagitis:_results_of_the_Progression_of_Gastroesophageal_Reflux_Disease_study_ L2 - https://doi.org/10.1111/j.1440-1746.2006.04549.x DB - PRIME DP - Unbound Medicine ER -