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Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro.
J Environ Biol. 2007 Apr; 28(2):279-82.JE

Abstract

Antioxidants and plant products are reported to reduce the genotoxic damage of steroids. In our present study we have tested different dosages of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in the presence of S9 mix. Treatments with nordihydroguaiaretic acid (NDGA) results in the reduction of the genotoxic damage. A significant decrease was observed at all the tested doses of NDGA in sister chromatic exchanges of number of abnormal cells. The results suggest a protective role of NDGA against the genotoxic damage.

Authors+Show Affiliations

Siddique YH
Department of Zoology, Section of Genetics, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202 002, India. yasir_hasansiddique@rediffmail.com
Ara G
No affiliation info available
Beg T
No affiliation info available
Afzal M
No affiliation info available

MeSH

Cells, CulturedChromosome AberrationsContraceptives, Oral, SyntheticDNA DamageEthynodiol DiacetateFemaleHumansLymphocytesMasoprocolMutagensProtective AgentsSister Chromatid Exchange

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17915765

Citation

Siddique, Yasir Hasan, et al. "Protective Role of Nordihydroguaiaretic Acid (NDGA) Against the Genotoxic Damage Induced By Ethynodiol Diacetate in Human Lymphocytes in Vitro." Journal of Environmental Biology, vol. 28, no. 2, 2007, pp. 279-82.
Siddique YH, Ara G, Beg T, et al. Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro. J Environ Biol. 2007;28(2):279-82.
Siddique, Y. H., Ara, G., Beg, T., & Afzal, M. (2007). Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro. Journal of Environmental Biology, 28(2), 279-82.
Siddique YH, et al. Protective Role of Nordihydroguaiaretic Acid (NDGA) Against the Genotoxic Damage Induced By Ethynodiol Diacetate in Human Lymphocytes in Vitro. J Environ Biol. 2007;28(2):279-82. PubMed PMID: 17915765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro. AU - Siddique,Yasir Hasan, AU - Ara,Gulshan, AU - Beg,Tanveer, AU - Afzal,Mohammad, PY - 2007/10/6/pubmed PY - 2008/1/16/medline PY - 2007/10/6/entrez SP - 279 EP - 82 JF - Journal of environmental biology JO - J Environ Biol VL - 28 IS - 2 N2 - Antioxidants and plant products are reported to reduce the genotoxic damage of steroids. In our present study we have tested different dosages of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in the presence of S9 mix. Treatments with nordihydroguaiaretic acid (NDGA) results in the reduction of the genotoxic damage. A significant decrease was observed at all the tested doses of NDGA in sister chromatic exchanges of number of abnormal cells. The results suggest a protective role of NDGA against the genotoxic damage. SN - 0254-8704 UR - https://www.unboundmedicine.com/medline/citation/17915765/Protective_role_of_nordihydroguaiaretic_acid__NDGA__against_the_genotoxic_damage_induced_by_ethynodiol_diacetate_in_human_lymphocytes_in_vitro_ DB - PRIME DP - Unbound Medicine ER -