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Diagnostic imaging findings and endocrine test results in dogs with pituitary-dependent hyperadrenocorticism that did or did not have neurologic abnormalities: 157 cases (1989-2005).
J Am Vet Med Assoc. 2007 Oct 01; 231(7):1081-5.JA

Abstract

OBJECTIVE

To compare imaging findings in dogs with pituitary-dependent hyperadrenocorticism (PDH) that did or did not have neurologic abnormalities. Design-Retrospective case series.

ANIMALS

157 dogs with PDH that did (n = 73) or did not (84) have neurologic abnormalities.

PROCEDURES

Medical records were reviewed for the presence and nature of clinical signs of CNS disease, and computed tomographic and magnetic resonance images were reviewed for evidence of a pituitary tumor.

RESULTS

60 of the 84 (71%) dogs without neurologic abnormalities and 48 of the 73 (66%) dogs with neurologic abnormalities had a detectable pituitary tumor. However, 17 of the 84 (20%) dogs without neurologic abnormalities had a pituitary macrotumor (ie, a tumor > or = 10 mm in height), and 41 of the 73 (56%) dogs with neurologic abnormalities did not have a detectable pituitary tumor or had a pituitary microtumor. Vague signs of CNS dysfunction (ie, lethargy, inappetence, and mental dullness) were more specific for detection of pituitary macrotumors than were CNS-specific signs (ie, seizure or blindness).

CONCLUSIONS AND CLINICAL RELEVANCE

Results suggested that there was no apparent relationship between a pituitary tumor and development of neurologic abnormalities in dogs with PDH. In addition, neurologic abnormalities in dogs with pituitary macrotumors were often vague (ie, lethargy, inappetence, and mental dullness).

Authors+Show Affiliations

Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17916035

Citation

Wood, Farica D., et al. "Diagnostic Imaging Findings and Endocrine Test Results in Dogs With Pituitary-dependent Hyperadrenocorticism That Did or Did Not Have Neurologic Abnormalities: 157 Cases (1989-2005)." Journal of the American Veterinary Medical Association, vol. 231, no. 7, 2007, pp. 1081-5.
Wood FD, Pollard RE, Uerling MR, et al. Diagnostic imaging findings and endocrine test results in dogs with pituitary-dependent hyperadrenocorticism that did or did not have neurologic abnormalities: 157 cases (1989-2005). J Am Vet Med Assoc. 2007;231(7):1081-5.
Wood, F. D., Pollard, R. E., Uerling, M. R., & Feldman, E. C. (2007). Diagnostic imaging findings and endocrine test results in dogs with pituitary-dependent hyperadrenocorticism that did or did not have neurologic abnormalities: 157 cases (1989-2005). Journal of the American Veterinary Medical Association, 231(7), 1081-5.
Wood FD, et al. Diagnostic Imaging Findings and Endocrine Test Results in Dogs With Pituitary-dependent Hyperadrenocorticism That Did or Did Not Have Neurologic Abnormalities: 157 Cases (1989-2005). J Am Vet Med Assoc. 2007 Oct 1;231(7):1081-5. PubMed PMID: 17916035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic imaging findings and endocrine test results in dogs with pituitary-dependent hyperadrenocorticism that did or did not have neurologic abnormalities: 157 cases (1989-2005). AU - Wood,Farica D, AU - Pollard,Rachel E, AU - Uerling,Megan R, AU - Feldman,Edward C, PY - 2007/10/6/pubmed PY - 2007/12/7/medline PY - 2007/10/6/entrez SP - 1081 EP - 5 JF - Journal of the American Veterinary Medical Association JO - J Am Vet Med Assoc VL - 231 IS - 7 N2 - OBJECTIVE: To compare imaging findings in dogs with pituitary-dependent hyperadrenocorticism (PDH) that did or did not have neurologic abnormalities. Design-Retrospective case series. ANIMALS: 157 dogs with PDH that did (n = 73) or did not (84) have neurologic abnormalities. PROCEDURES: Medical records were reviewed for the presence and nature of clinical signs of CNS disease, and computed tomographic and magnetic resonance images were reviewed for evidence of a pituitary tumor. RESULTS: 60 of the 84 (71%) dogs without neurologic abnormalities and 48 of the 73 (66%) dogs with neurologic abnormalities had a detectable pituitary tumor. However, 17 of the 84 (20%) dogs without neurologic abnormalities had a pituitary macrotumor (ie, a tumor > or = 10 mm in height), and 41 of the 73 (56%) dogs with neurologic abnormalities did not have a detectable pituitary tumor or had a pituitary microtumor. Vague signs of CNS dysfunction (ie, lethargy, inappetence, and mental dullness) were more specific for detection of pituitary macrotumors than were CNS-specific signs (ie, seizure or blindness). CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that there was no apparent relationship between a pituitary tumor and development of neurologic abnormalities in dogs with PDH. In addition, neurologic abnormalities in dogs with pituitary macrotumors were often vague (ie, lethargy, inappetence, and mental dullness). SN - 0003-1488 UR - https://www.unboundmedicine.com/medline/citation/17916035/Diagnostic_imaging_findings_and_endocrine_test_results_in_dogs_with_pituitary_dependent_hyperadrenocorticism_that_did_or_did_not_have_neurologic_abnormalities:_157_cases__1989_2005__ L2 - https://avmajournals.avma.org/doi/10.2460/javma.231.7.1081?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -