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Comparison of gonioscopy and anterior segment ocular coherence tomography in detecting angle closure in different quadrants of the anterior chamber angle.
Ophthalmology. 2008 May; 115(5):769-74.O

Abstract

PURPOSE

To compare the performance of gonioscopy and anterior segment (AS) optical coherence tomography (OCT) in detecting angle closure in the different quadrants of the anterior chamber angle (ACA).

DESIGN

Cross-sectional observational study.

PARTICIPANTS

Five hundred two consecutive subjects more than 50 years of age with no previous ophthalmic problems recruited from a community clinic in Singapore.

METHODS

All subjects underwent gonioscopy and AS OCT imaging in the dark. Using gonioscopy, the ACA was graded using the Scheie system by a single examiner masked to AS OCT findings.

MAIN OUTCOME MEASURES

The ACA in a particular quadrant was classified as closed if the posterior trabecular meshwork could not be seen on gonioscopy. A closed ACA on AS OCT imaging was defined by the presence of any contact between the iris and angle wall anterior to the scleral spur.

RESULTS

After excluding eyes with poor image quality, a total of 423 right eyes were included in the analysis. A closed angle in at least 1 quadrant was observed in 59% of the eyes by AS OCT and in 33% of the eyes by gonioscopy (P<0.001), with fair agreement between the two methods (kappa = 0.40). The frequency of closed angles by AS OCT and gonioscopy were 48% versus 29% superiorly, 43% versus 22% inferiorly, 18% versus 14% nasally, and 12% versus 20% temporally, respectively. Of the 119 of 1692 quadrants that were closed on gonioscopy but open on AS OCT, a steep iris profile was present in 61 (51%) of 119 quadrants on AS OCT, and of the 276 of 1692 quadrants that were open on gonioscopy but closed on AS OCT, 196 (71%) of 276 quadrants showed short iridoangle contact on AS OCT.

CONCLUSIONS

The highest rates of closed angles on gonioscopy and AS OCT images were observed in the superior quadrant. Anterior segment OCT tended to detect more closed ACAs than gonioscopy, particularly in the superior and inferior quadrants. Variations in the iris profile and level of iridoangle contact also may explain some of the differences seen between gonioscopy and AS OCT.

Authors+Show Affiliations

Singapore Eye Research Institute and Singapore National Eye Center, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17916377

Citation

Sakata, Lisandro M., et al. "Comparison of Gonioscopy and Anterior Segment Ocular Coherence Tomography in Detecting Angle Closure in Different Quadrants of the Anterior Chamber Angle." Ophthalmology, vol. 115, no. 5, 2008, pp. 769-74.
Sakata LM, Lavanya R, Friedman DS, et al. Comparison of gonioscopy and anterior segment ocular coherence tomography in detecting angle closure in different quadrants of the anterior chamber angle. Ophthalmology. 2008;115(5):769-74.
Sakata, L. M., Lavanya, R., Friedman, D. S., Aung, H. T., Gao, H., Kumar, R. S., Foster, P. J., & Aung, T. (2008). Comparison of gonioscopy and anterior segment ocular coherence tomography in detecting angle closure in different quadrants of the anterior chamber angle. Ophthalmology, 115(5), 769-74.
Sakata LM, et al. Comparison of Gonioscopy and Anterior Segment Ocular Coherence Tomography in Detecting Angle Closure in Different Quadrants of the Anterior Chamber Angle. Ophthalmology. 2008;115(5):769-74. PubMed PMID: 17916377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of gonioscopy and anterior segment ocular coherence tomography in detecting angle closure in different quadrants of the anterior chamber angle. AU - Sakata,Lisandro M, AU - Lavanya,Raghavan, AU - Friedman,David S, AU - Aung,Han T, AU - Gao,Hong, AU - Kumar,Rajesh S, AU - Foster,Paul J, AU - Aung,Tin, Y1 - 2007/10/04/ PY - 2007/02/23/received PY - 2007/05/26/revised PY - 2007/06/14/accepted PY - 2007/10/6/pubmed PY - 2008/5/7/medline PY - 2007/10/6/entrez SP - 769 EP - 74 JF - Ophthalmology JO - Ophthalmology VL - 115 IS - 5 N2 - PURPOSE: To compare the performance of gonioscopy and anterior segment (AS) optical coherence tomography (OCT) in detecting angle closure in the different quadrants of the anterior chamber angle (ACA). DESIGN: Cross-sectional observational study. PARTICIPANTS: Five hundred two consecutive subjects more than 50 years of age with no previous ophthalmic problems recruited from a community clinic in Singapore. METHODS: All subjects underwent gonioscopy and AS OCT imaging in the dark. Using gonioscopy, the ACA was graded using the Scheie system by a single examiner masked to AS OCT findings. MAIN OUTCOME MEASURES: The ACA in a particular quadrant was classified as closed if the posterior trabecular meshwork could not be seen on gonioscopy. A closed ACA on AS OCT imaging was defined by the presence of any contact between the iris and angle wall anterior to the scleral spur. RESULTS: After excluding eyes with poor image quality, a total of 423 right eyes were included in the analysis. A closed angle in at least 1 quadrant was observed in 59% of the eyes by AS OCT and in 33% of the eyes by gonioscopy (P<0.001), with fair agreement between the two methods (kappa = 0.40). The frequency of closed angles by AS OCT and gonioscopy were 48% versus 29% superiorly, 43% versus 22% inferiorly, 18% versus 14% nasally, and 12% versus 20% temporally, respectively. Of the 119 of 1692 quadrants that were closed on gonioscopy but open on AS OCT, a steep iris profile was present in 61 (51%) of 119 quadrants on AS OCT, and of the 276 of 1692 quadrants that were open on gonioscopy but closed on AS OCT, 196 (71%) of 276 quadrants showed short iridoangle contact on AS OCT. CONCLUSIONS: The highest rates of closed angles on gonioscopy and AS OCT images were observed in the superior quadrant. Anterior segment OCT tended to detect more closed ACAs than gonioscopy, particularly in the superior and inferior quadrants. Variations in the iris profile and level of iridoangle contact also may explain some of the differences seen between gonioscopy and AS OCT. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/17916377/Comparison_of_gonioscopy_and_anterior_segment_ocular_coherence_tomography_in_detecting_angle_closure_in_different_quadrants_of_the_anterior_chamber_angle_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(07)00727-0 DB - PRIME DP - Unbound Medicine ER -