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Soluble CD14 and toll-like receptor-2 are potential salivary biomarkers for oral lichen planus and burning mouth syndrome.
Clin Immunol. 2008 Jan; 126(1):31-7.CI

Abstract

Oral lichen planus (OLP) and burning mouth syndrome (BMS) are chronic conditions affecting the oral mucosa characterized by pain and burning sensation. Saliva plays a significant role in the maintenance of physical and functional integrity of normal oral mucosa. Identification of potential "salivary biomarkers" for early diagnosis and/or monitoring of human diseases is being explored. We investigated the soluble forms of innate immune associated proteins CD14 and toll-like receptor-2 in unstimulated whole saliva (UWS) as potential biomarkers for OLP and BMS. Our results suggest that the levels of sCD14 and sTLR-2 in UWS were upregulated in OLP and BMS respectively. In addition, oral epithelial cells in the saliva of patients with OLP and BMS exhibited elevated levels of CD14 mRNA and decreased levels of TLR-2 mRNA. Interestingly, presence of co-existent oral candidiasis nullified these changes.

Authors+Show Affiliations

Department of Oral Pathology, Medicine and Radiology, Indiana University School of Dentistry, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA. mysriniv@iupui.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17916440

Citation

Srinivasan, Mythily, et al. "Soluble CD14 and Toll-like Receptor-2 Are Potential Salivary Biomarkers for Oral Lichen Planus and Burning Mouth Syndrome." Clinical Immunology (Orlando, Fla.), vol. 126, no. 1, 2008, pp. 31-7.
Srinivasan M, Kodumudi KN, Zunt SL. Soluble CD14 and toll-like receptor-2 are potential salivary biomarkers for oral lichen planus and burning mouth syndrome. Clin Immunol. 2008;126(1):31-7.
Srinivasan, M., Kodumudi, K. N., & Zunt, S. L. (2008). Soluble CD14 and toll-like receptor-2 are potential salivary biomarkers for oral lichen planus and burning mouth syndrome. Clinical Immunology (Orlando, Fla.), 126(1), 31-7.
Srinivasan M, Kodumudi KN, Zunt SL. Soluble CD14 and Toll-like Receptor-2 Are Potential Salivary Biomarkers for Oral Lichen Planus and Burning Mouth Syndrome. Clin Immunol. 2008;126(1):31-7. PubMed PMID: 17916440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soluble CD14 and toll-like receptor-2 are potential salivary biomarkers for oral lichen planus and burning mouth syndrome. AU - Srinivasan,Mythily, AU - Kodumudi,Krithika N, AU - Zunt,Susan L, Y1 - 2007/10/03/ PY - 2007/06/24/received PY - 2007/08/08/revised PY - 2007/08/17/accepted PY - 2007/10/6/pubmed PY - 2008/2/26/medline PY - 2007/10/6/entrez SP - 31 EP - 7 JF - Clinical immunology (Orlando, Fla.) JO - Clin Immunol VL - 126 IS - 1 N2 - Oral lichen planus (OLP) and burning mouth syndrome (BMS) are chronic conditions affecting the oral mucosa characterized by pain and burning sensation. Saliva plays a significant role in the maintenance of physical and functional integrity of normal oral mucosa. Identification of potential "salivary biomarkers" for early diagnosis and/or monitoring of human diseases is being explored. We investigated the soluble forms of innate immune associated proteins CD14 and toll-like receptor-2 in unstimulated whole saliva (UWS) as potential biomarkers for OLP and BMS. Our results suggest that the levels of sCD14 and sTLR-2 in UWS were upregulated in OLP and BMS respectively. In addition, oral epithelial cells in the saliva of patients with OLP and BMS exhibited elevated levels of CD14 mRNA and decreased levels of TLR-2 mRNA. Interestingly, presence of co-existent oral candidiasis nullified these changes. SN - 1521-6616 UR - https://www.unboundmedicine.com/medline/citation/17916440/Soluble_CD14_and_toll_like_receptor_2_are_potential_salivary_biomarkers_for_oral_lichen_planus_and_burning_mouth_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6616(07)01328-9 DB - PRIME DP - Unbound Medicine ER -