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Antinociceptive, anti-inflammatory and antipyretic properties of the aqueous extract of Bauhinia purpurea leaves in experimental animals.
Med Princ Pract. 2007; 16(6):443-9.MP

Abstract

OBJECTIVE

The present study was carried out to determine the antinociceptive, anti-inflammatory and antipyretic activities of the aqueous extract of Bauhinia purpurea leaves using animal models.

MATERIALS AND METHODS

The air-dried, powdered leaves (approximately 20 g) were soaked in distilled water (1:20; w/v) at room temperature for 72 h and the supernatant obtained was freeze-dried. The crude dried extract (approximately 2.4 g) was prepared in doses of 6.0, 30.0 and 60.0 mg/kg, and subjected to the respective antinociceptive (abdominal constriction, hot plate and formalin tests), anti-inflammatory (carrageenan-induced paw edema test) and antipyretic (brewer's yeast-induced pyrexia test) assays.

RESULTS

The results obtained indicate that the extract possessed significant (p < 0.05) antinociceptive, anti-inflammatory and antipyretic activities, which were not dependent on the doses of extract used. The highest concentration of extract was less effective as an anti-inflammatory and an antipyretic agent.

CONCLUSION

This study showed that the aqueous extract of B. purpurea leaves possesses potential pharmacological activities that require further investigation and, thus, confirms the folklore use of the plant in the treatment of ailments associated with pain and inflammation.

Authors+Show Affiliations

Faculty of Pharmacy, Universiti Teknologi Mara, Shah Alam, Selangor, Malaysia. shaza8174@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17917444

Citation

Zakaria, Zainul Amiruddin, et al. "Antinociceptive, Anti-inflammatory and Antipyretic Properties of the Aqueous Extract of Bauhinia Purpurea Leaves in Experimental Animals." Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre, vol. 16, no. 6, 2007, pp. 443-9.
Zakaria ZA, Wen LY, Abdul Rahman NI, et al. Antinociceptive, anti-inflammatory and antipyretic properties of the aqueous extract of Bauhinia purpurea leaves in experimental animals. Med Princ Pract. 2007;16(6):443-9.
Zakaria, Z. A., Wen, L. Y., Abdul Rahman, N. I., Abdul Ayub, A. H., Sulaiman, M. R., & Gopalan, H. K. (2007). Antinociceptive, anti-inflammatory and antipyretic properties of the aqueous extract of Bauhinia purpurea leaves in experimental animals. Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre, 16(6), 443-9.
Zakaria ZA, et al. Antinociceptive, Anti-inflammatory and Antipyretic Properties of the Aqueous Extract of Bauhinia Purpurea Leaves in Experimental Animals. Med Princ Pract. 2007;16(6):443-9. PubMed PMID: 17917444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive, anti-inflammatory and antipyretic properties of the aqueous extract of Bauhinia purpurea leaves in experimental animals. AU - Zakaria,Zainul Amiruddin, AU - Wen,Loo Yi, AU - Abdul Rahman,Nurul Izzah, AU - Abdul Ayub,Abdul Halim, AU - Sulaiman,Mohd Roslan, AU - Gopalan,Hanan Kumar, PY - 2006/11/08/received PY - 2007/03/13/accepted PY - 2007/10/6/pubmed PY - 2007/12/6/medline PY - 2007/10/6/entrez SP - 443 EP - 9 JF - Medical principles and practice : international journal of the Kuwait University, Health Science Centre JO - Med Princ Pract VL - 16 IS - 6 N2 - OBJECTIVE: The present study was carried out to determine the antinociceptive, anti-inflammatory and antipyretic activities of the aqueous extract of Bauhinia purpurea leaves using animal models. MATERIALS AND METHODS: The air-dried, powdered leaves (approximately 20 g) were soaked in distilled water (1:20; w/v) at room temperature for 72 h and the supernatant obtained was freeze-dried. The crude dried extract (approximately 2.4 g) was prepared in doses of 6.0, 30.0 and 60.0 mg/kg, and subjected to the respective antinociceptive (abdominal constriction, hot plate and formalin tests), anti-inflammatory (carrageenan-induced paw edema test) and antipyretic (brewer's yeast-induced pyrexia test) assays. RESULTS: The results obtained indicate that the extract possessed significant (p < 0.05) antinociceptive, anti-inflammatory and antipyretic activities, which were not dependent on the doses of extract used. The highest concentration of extract was less effective as an anti-inflammatory and an antipyretic agent. CONCLUSION: This study showed that the aqueous extract of B. purpurea leaves possesses potential pharmacological activities that require further investigation and, thus, confirms the folklore use of the plant in the treatment of ailments associated with pain and inflammation. SN - 1423-0151 UR - https://www.unboundmedicine.com/medline/citation/17917444/Antinociceptive_anti_inflammatory_and_antipyretic_properties_of_the_aqueous_extract_of_Bauhinia_purpurea_leaves_in_experimental_animals_ L2 - https://www.karger.com?DOI=10.1159/000107749 DB - PRIME DP - Unbound Medicine ER -