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Light chain deposition disease without detectable light chains in serum or urine. Report of a case and review of the literature.
Neth J Med. 1991 Oct; 39(3-4):142-7.NJ

Abstract

A patient presenting with a nephrotic syndrome and chronic renal failure caused by light chain deposition disease (LCDD) without detectable light chains in serum and urine is presented. Only a few patients with LCDD but without detectable light chains in serum and urine have hitherto been reported. The diagnosis was made by light-microscopic and immunofluorescent examination of a percutaneous renal biopsy. The histological differential diagnosis of LCDD includes diabetic glomerulosclerosis, renal amyloidosis and membranoproliferative glomerulonephritis. For the histological diagnosis of LCDD, immunofluorescence using anti-kappa and anti-lambda antisera is essential. Although renal involvement is a constant feature in LCDD, other sites of deposition of light chains have been reported. The absence of detectable light chains in serum or urine is discussed.

Authors+Show Affiliations

Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

1791875

Citation

van Ingen, G, et al. "Light Chain Deposition Disease Without Detectable Light Chains in Serum or Urine. Report of a Case and Review of the Literature." The Netherlands Journal of Medicine, vol. 39, no. 3-4, 1991, pp. 142-7.
van Ingen G, van Bronswijk H, Meijer CJ, et al. Light chain deposition disease without detectable light chains in serum or urine. Report of a case and review of the literature. Neth J Med. 1991;39(3-4):142-7.
van Ingen, G., van Bronswijk, H., Meijer, C. J., & Stel, H. V. (1991). Light chain deposition disease without detectable light chains in serum or urine. Report of a case and review of the literature. The Netherlands Journal of Medicine, 39(3-4), 142-7.
van Ingen G, et al. Light Chain Deposition Disease Without Detectable Light Chains in Serum or Urine. Report of a Case and Review of the Literature. Neth J Med. 1991;39(3-4):142-7. PubMed PMID: 1791875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Light chain deposition disease without detectable light chains in serum or urine. Report of a case and review of the literature. AU - van Ingen,G, AU - van Bronswijk,H, AU - Meijer,C J, AU - Stel,H V, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez SP - 142 EP - 7 JF - The Netherlands journal of medicine JO - Neth J Med VL - 39 IS - 3-4 N2 - A patient presenting with a nephrotic syndrome and chronic renal failure caused by light chain deposition disease (LCDD) without detectable light chains in serum and urine is presented. Only a few patients with LCDD but without detectable light chains in serum and urine have hitherto been reported. The diagnosis was made by light-microscopic and immunofluorescent examination of a percutaneous renal biopsy. The histological differential diagnosis of LCDD includes diabetic glomerulosclerosis, renal amyloidosis and membranoproliferative glomerulonephritis. For the histological diagnosis of LCDD, immunofluorescence using anti-kappa and anti-lambda antisera is essential. Although renal involvement is a constant feature in LCDD, other sites of deposition of light chains have been reported. The absence of detectable light chains in serum or urine is discussed. SN - 0300-2977 UR - https://www.unboundmedicine.com/medline/citation/1791875/Light_chain_deposition_disease_without_detectable_light_chains_in_serum_or_urine__Report_of_a_case_and_review_of_the_literature_ L2 - http://www.diseaseinfosearch.org/result/4223 DB - PRIME DP - Unbound Medicine ER -