Cytotoxic lignans from the stem bark of Magnolia officinalis.J Nat Prod. 2007 Oct; 70(10):1687-9.JN
Three new lignans, 4'-methoxymagndialdehyde (1), 4'-methoxymagnaldehyde B (2), and 4'-methoxymagnaldehyde E (3), were isolated from hexane- and EtOAc-soluble fractions of the stem bark of Magnolia officinalis, together with eight known compounds (4- 11). The structures of compounds 1- 3 were determined on the basis of spectroscopic and physicochemical data analysis. Compounds 1- 11 were tested in vitro for their cytotoxic activity against the K562, HeLa, and A549 cancer cell lines. Among the compounds tested, compound 1 showed the most potent cytotoxic activity against these cancer cell lines, with IC50 values of 3.9, 1.5, and 3.7 microg/mL, respectively.