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Cytotoxic lignans from the stem bark of Magnolia officinalis.
J Nat Prod. 2007 Oct; 70(10):1687-9.JN

Abstract

Three new lignans, 4'-methoxymagndialdehyde (1), 4'-methoxymagnaldehyde B (2), and 4'-methoxymagnaldehyde E (3), were isolated from hexane- and EtOAc-soluble fractions of the stem bark of Magnolia officinalis, together with eight known compounds (4- 11). The structures of compounds 1- 3 were determined on the basis of spectroscopic and physicochemical data analysis. Compounds 1- 11 were tested in vitro for their cytotoxic activity against the K562, HeLa, and A549 cancer cell lines. Among the compounds tested, compound 1 showed the most potent cytotoxic activity against these cancer cell lines, with IC50 values of 3.9, 1.5, and 3.7 microg/mL, respectively.

Authors+Show Affiliations

Youn UJ
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
Chen QC
No affiliation info available
Jin WY
No affiliation info available
Lee IS
No affiliation info available
Kim HJ
No affiliation info available
Lee JP
No affiliation info available
Chang MJ
No affiliation info available
Min BS
No affiliation info available
Bae KH
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicDrug Screening Assays, AntitumorHeLa CellsHumansInhibitory Concentration 50KoreaLignansMagnoliaMolecular StructurePlant BarkPlant StemsPlants, Medicinal

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17918910

Citation

Youn, Ui-Joung, et al. "Cytotoxic Lignans From the Stem Bark of Magnolia Officinalis." Journal of Natural Products, vol. 70, no. 10, 2007, pp. 1687-9.
Youn UJ, Chen QC, Jin WY, et al. Cytotoxic lignans from the stem bark of Magnolia officinalis. J Nat Prod. 2007;70(10):1687-9.
Youn, U. J., Chen, Q. C., Jin, W. Y., Lee, I. S., Kim, H. J., Lee, J. P., Chang, M. J., Min, B. S., & Bae, K. H. (2007). Cytotoxic lignans from the stem bark of Magnolia officinalis. Journal of Natural Products, 70(10), 1687-9.
Youn UJ, et al. Cytotoxic Lignans From the Stem Bark of Magnolia Officinalis. J Nat Prod. 2007;70(10):1687-9. PubMed PMID: 17918910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic lignans from the stem bark of Magnolia officinalis. AU - Youn,Ui-Joung, AU - Chen,Quan Cheng, AU - Jin,Wen-Yi, AU - Lee,Ik-Soo, AU - Kim,Hong-Jin, AU - Lee,Jong-Pill, AU - Chang,Min-Jung, AU - Min,Byung-Sun, AU - Bae,Ki-Hwan, Y1 - 2007/10/06/ PY - 2007/10/9/pubmed PY - 2007/12/18/medline PY - 2007/10/9/entrez SP - 1687 EP - 9 JF - Journal of natural products JO - J Nat Prod VL - 70 IS - 10 N2 - Three new lignans, 4'-methoxymagndialdehyde (1), 4'-methoxymagnaldehyde B (2), and 4'-methoxymagnaldehyde E (3), were isolated from hexane- and EtOAc-soluble fractions of the stem bark of Magnolia officinalis, together with eight known compounds (4- 11). The structures of compounds 1- 3 were determined on the basis of spectroscopic and physicochemical data analysis. Compounds 1- 11 were tested in vitro for their cytotoxic activity against the K562, HeLa, and A549 cancer cell lines. Among the compounds tested, compound 1 showed the most potent cytotoxic activity against these cancer cell lines, with IC50 values of 3.9, 1.5, and 3.7 microg/mL, respectively. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/17918910/Cytotoxic_lignans_from_the_stem_bark_of_Magnolia_officinalis_ L2 - https://doi.org/10.1021/np070388c DB - PRIME DP - Unbound Medicine ER -