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Colonoscopic screening of first-degree relatives of patients with large adenomas: increased risk of colorectal tumors.
Gastroenterology 2007; 133(4):1086-92G

Abstract

BACKGROUND & AIMS

The risk of developing colorectal neoplasia is not well established among family members of individuals with large adenomas, and screening strategies remain under debate in this population. This study aimed at quantifying the risk of colorectal adenomas and cancers using colonoscopic screening in first-degree relatives of patients with large adenomas.

METHODS

This case-control study was performed in 18 endoscopic units of French nonuniversity hospitals. A colonoscopy was offered to first-degree relatives of 306 index cases with adenomas > or =10 mm if they were alive, aged 40-75 years, and could be contacted by the index case. Among them, 168 were examined and matched for age, sex, and geographical area with 2 controls (n = 307). Controls were randomly selected from 1362 consecutive patients aged 40-75 years having undergone a colonoscopy for minor symptoms.

RESULTS

The prevalence of large adenomas and cancers was 8.4% and 4.2%, in relatives and controls, respectively. Odds ratios (ORs) associated with a history of large adenomas in relatives were 2.27 (95% confidence interval [CI], 1.01-5.09) for cancers or large adenomas, 1.21 (95% CI, 0.68-2.15) for small adenomas, and 1.56 (95% CI, 0.96-2.53) for all colorectal neoplasia. The risk of large adenomas and cancers was higher in relatives of index cases younger than 60 years (OR, 3.82; 95% CI, 0.92-15.87) and when the index case had large distal adenomas (OR, 3.14; 95% CI, 1.27-7.73).

CONCLUSIONS

First-degree relatives of patients with large adenomas are at increased risk of developing colorectal cancers or large adenomas. This result has implications for screening in this high-risk population.

Authors+Show Affiliations

INSERM Unité 866, Dijon, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17919484

Citation

Cottet, Vanessa, et al. "Colonoscopic Screening of First-degree Relatives of Patients With Large Adenomas: Increased Risk of Colorectal Tumors." Gastroenterology, vol. 133, no. 4, 2007, pp. 1086-92.
Cottet V, Pariente A, Nalet B, et al. Colonoscopic screening of first-degree relatives of patients with large adenomas: increased risk of colorectal tumors. Gastroenterology. 2007;133(4):1086-92.
Cottet, V., Pariente, A., Nalet, B., Lafon, J., Milan, C., Olschwang, S., ... Bonithon-Kopp, C. (2007). Colonoscopic screening of first-degree relatives of patients with large adenomas: increased risk of colorectal tumors. Gastroenterology, 133(4), pp. 1086-92.
Cottet V, et al. Colonoscopic Screening of First-degree Relatives of Patients With Large Adenomas: Increased Risk of Colorectal Tumors. Gastroenterology. 2007;133(4):1086-92. PubMed PMID: 17919484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Colonoscopic screening of first-degree relatives of patients with large adenomas: increased risk of colorectal tumors. AU - Cottet,Vanessa, AU - Pariente,Alexandre, AU - Nalet,Bernard, AU - Lafon,Jacques, AU - Milan,Chantal, AU - Olschwang,Sylviane, AU - Bonaiti-Pellié,Catherine, AU - Faivre,Jean, AU - Bonithon-Kopp,Claire, AU - ,, Y1 - 2007/07/25/ PY - 2006/12/22/received PY - 2007/07/16/accepted PY - 2007/10/9/pubmed PY - 2007/10/27/medline PY - 2007/10/9/entrez SP - 1086 EP - 92 JF - Gastroenterology JO - Gastroenterology VL - 133 IS - 4 N2 - BACKGROUND & AIMS: The risk of developing colorectal neoplasia is not well established among family members of individuals with large adenomas, and screening strategies remain under debate in this population. This study aimed at quantifying the risk of colorectal adenomas and cancers using colonoscopic screening in first-degree relatives of patients with large adenomas. METHODS: This case-control study was performed in 18 endoscopic units of French nonuniversity hospitals. A colonoscopy was offered to first-degree relatives of 306 index cases with adenomas > or =10 mm if they were alive, aged 40-75 years, and could be contacted by the index case. Among them, 168 were examined and matched for age, sex, and geographical area with 2 controls (n = 307). Controls were randomly selected from 1362 consecutive patients aged 40-75 years having undergone a colonoscopy for minor symptoms. RESULTS: The prevalence of large adenomas and cancers was 8.4% and 4.2%, in relatives and controls, respectively. Odds ratios (ORs) associated with a history of large adenomas in relatives were 2.27 (95% confidence interval [CI], 1.01-5.09) for cancers or large adenomas, 1.21 (95% CI, 0.68-2.15) for small adenomas, and 1.56 (95% CI, 0.96-2.53) for all colorectal neoplasia. The risk of large adenomas and cancers was higher in relatives of index cases younger than 60 years (OR, 3.82; 95% CI, 0.92-15.87) and when the index case had large distal adenomas (OR, 3.14; 95% CI, 1.27-7.73). CONCLUSIONS: First-degree relatives of patients with large adenomas are at increased risk of developing colorectal cancers or large adenomas. This result has implications for screening in this high-risk population. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/17919484/Colonoscopic_screening_of_first_degree_relatives_of_patients_with_large_adenomas:_increased_risk_of_colorectal_tumors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(07)01403-5 DB - PRIME DP - Unbound Medicine ER -